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Leptin and reproduction

Published online by Cambridge University Press:  28 February 2007

Nigel Hoggard ,
Leif Hunter ,
Paul Trayhurn ,
Lynda M. Williams  and
Julian G. Mercer
Nigel Hoggard*
Affiliation:
Molecular Physiology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Leif Hunter
Affiliation:
Molecular Physiology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Paul Trayhurn
Affiliation:
Molecular Physiology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Lynda M. Williams
Affiliation:
Molecular Neuroendocrinology Unit, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Julian G. Mercer
Affiliation:
Molecular Neuroendocrinology Unit, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
*
*Corresponding author: Dr N. Hoggard, fax +44(0)1224 716622, email [email protected]
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Abstract

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Type
Simposium on ‘Leptin: energy regulation and beyond’
Information
Proceedings of the Nutrition Society , Volume 57 , Issue 3 , August 1998 , pp. 421 - 427
Copyright
Copyright © The Nutrition Society 1998

References

Ahima, RS, Dushay, J, Flier, SN, prabakaran, D & Flier, JS (1997) Leptin accelerates the onset of puberty in normal female mice. Journal of Clinical Investigation 99, 391–395.CrossRefGoogle ScholarPubMed
Barash, IA, Cheung, CC, Weigle, DS, Ren, HP, Kabigting, EB, Kuijper, JL, Clifton, DK & Steiner, RA (1996) Leptin is a metabolic signal to the reproductive-system. Endocrinology 137, 3144–3147.CrossRefGoogle Scholar
Batt, RAL (1972) The response of the reproductive system in the female mutant mouse, obese (genotype ob/ob) to gonadotrophin-releasing hormones. Journal of Reproduction and Fertility 31, 496–497.CrossRefGoogle Scholar
Batt, R, Everard, D, Gilles, G, Wikinson, M, Wilson, C & Yeo, T (1982) Investigation into hypogonadism of the obese mouse (genotype ob/ob). Journal of Reproduction and Fertility 64, 363–371.CrossRefGoogle ScholarPubMed
Bennett, BD, Solar, GP, Yuan, JQ, Mathias, J, Thomas, GR & Matthews, W (1996) A role for leptin and its cognate receptor in hematopoiesis. Current Biology 6, 1170–1180.CrossRefGoogle ScholarPubMed
Bi, S, Gavrilova, O, Gong, DW, Mason, MM & Reitman, M (1997) Identification of a placental enhancer for the human leptin gene. Journal of Biological Chemistry 272, 30583–30588.CrossRefGoogle ScholarPubMed
Carro, E, Pinilla, L, Seoane, LM, Considine, RV, Aguilar, E, Casanueva, FF & Dieguez, C (1997) Influence of endogenous leptin tone on the estrous cycle and luteinizing hormone pulsatility in female rats. Neuroendocrinology 66, 375–377.CrossRefGoogle ScholarPubMed
Chehab, FF, Lim, ME & Lu, RH (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 12, 318–320.CrossRefGoogle ScholarPubMed
Chehab, FF, Mounzih, K, Lu, RH & Lim, ME (1997) Early onset of reproductive function in normal female mice treated with leptin. Science 275, 88–90.CrossRefGoogle ScholarPubMed
Chien, EK, Hara, M, Rouard, M, Yano, H, Phillippe, M, Polonsky, KS & Bell, GI (1997) Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats. Biochemical and Biophysical Research Communications 237, 476–480.CrossRefGoogle ScholarPubMed
Cioffi, JA, Shafer, AW, Zupancic, TJ, Smith-Gbur, J, Mikhail, A, Platika, D & Snodgrass, HR (1996) Novel B219/Ob receptor isoforms – possible role of leptin in hematopoiesis and reproduction. Nature Medicine 2, 585–589.CrossRefGoogle ScholarPubMed
De Souza, M & Metzger, D (1991) Reproductive dysfunction in amenorrheic athletes and anorexic patients: a review. Medicine and Science in Sports and Exercise 23, 995–1007.CrossRefGoogle ScholarPubMed
Gainsford, T, Willson, TA, Metcalf, D, Handman, E, Mcfarlane, C, Ng, A, Nicola, NA, Alexander, WS & Hilton, DJ (1996) Leptin can induce proliferation, differentiation, and functional activation of hematopoietic-cells. Proceedings of the National Academy of Sciences USA 93, 14564–14568.CrossRefGoogle Scholar
Gavrilova, O, Barr, V, Marcus-Samuels, B & Reitman, M (1997) Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. Journal of Biological Chemistry 272, 30546–30551.CrossRefGoogle ScholarPubMed
Ghilardi, N, Ziegler, S, Wiestner, A, Stoffel, R, Heim, MH & Skoda, RC (1996) Defective STAT signaling by the leptin receptors in diabetic mice. Proceedings of the National Academy of Sciences USA 93, 6231–6235.CrossRefGoogle ScholarPubMed
Green, ED, Maffei, M, Braden, VV, Proenca, R, Desilva, U, Zhang, YY, Chua, SC, Leibel, RL, Weissenbach, J & Friedman, JM (1995) The human obese (Ob) gene – RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome-7. Genome Research 5, 5–12.CrossRefGoogle ScholarPubMed
Griffen, M, South, S, Yankov, V, Booth, RJ, Asplin, C, Veldhuis, J & Evans, W (1994) Insulin dependent diabetes mellitus and menstrual dysfunction. Annals of Medicine 26, 331–340.CrossRefGoogle Scholar
Hardie, L, Trayhum, P, Abramovich, D & Fowler, P (1997) Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clinical Endocrinology 47, 101–106.CrossRefGoogle ScholarPubMed
Hoggard, N, Hunter, L, Duncan, JS, Williams, LM, Trayhurn, P & Mercer, JG (1997 a) Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proceedings of the National Academy of Sciences USA 94, 11073–11078.CrossRefGoogle ScholarPubMed
Hoggard, N, Mercer, JG, Rayner, DV, Moar, K, Trayhum, P & Williams, LM (1997 b) Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization. Biochemical and Biophysical Research Communications 232, 383–387.CrossRefGoogle ScholarPubMed
Ingalis, AM, Dickie, MM & Snell, GD (1950) Obese, a new mutation in the house mouse. Journal of Heredity 45, 317–318.CrossRefGoogle Scholar
Kalra, S (1993) Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge. Endocrine Reviews 14, 507–538.Google ScholarPubMed
Kennedy, GC & Mitra, J (1963) Hypothalamic control of energy balance and the reproductive cycle in the rat. Journal of Physiology 166, 395–407.CrossRefGoogle ScholarPubMed
Lane, PW & Dickie, MM (1954) Relative sterility in obese males corrected by dietary restriction. Journal of Heredity 45, 56–58.CrossRefGoogle Scholar
Lee, GH, Proenca, R, Montez, JM, Carroll, KM, Darvishzadeh, JG, Lee, JI & Friedman, JM (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632–635.CrossRefGoogle ScholarPubMed
Masuzaki, H, Ogawa, Y, Sagawa, N, Hosoda, K, Matsumoto, T, Mise, H, Nishimura, H, Yoshimasa, Y, Tanaka, I, Mori, T & Nakao, K (1997) Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans. Nature Medicine 3, 1029–1033.CrossRefGoogle ScholarPubMed
Mercer, JG, Hoggard, N, Williams, LM, Lawrence, CB, Hannah, LT, Morgan, PJ & Trayhurn, P (1996 a) Coexpression of leptin receptor and preproneuropeptide-Y messenger-RNA in arcuate nucleus of mouse hypothalamus. Journal of Neuroendocrinology 8, 733–735.CrossRefGoogle ScholarPubMed
Mercer, JG, Hoggard, N, Williams, LM, Lawrence, CB, Hannah, LT & Trayhum, P (1996 b) Localization of leptin receptor messenger-RNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain-regions by in-situ hybridization. FEBS Letters 387, 113–116.CrossRefGoogle Scholar
Montague, CT, Farooqi, IS, Whitehead, JP, Soos, MA, Rau, H, Wareham, NJ, Sewter, CP, Digby, JE, Mohammed, SN, Hurst, JA, Cheetham, CH, Earley, AR, Bamett, AH, Prins, JB & O'rahilly, S (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903–908.CrossRefGoogle ScholarPubMed
Schwartz, MW, Seeley, RJ, Campfield, LA, Burn, P & Baskin, DG (1996) Identification of targets of leptin action in rat hypothalamus. Journal of Clinical Investigation 98, 1101–1106.CrossRefGoogle ScholarPubMed
Senaris, R, Garcia-Caballero, T, Casabiell, X, Gallego, R, Castro, R, Considine, RV, Dieguez, C & Casanueva, FF (1997) Synthesis of leptin in human placenta. Endocrinology 138, 4501–4504.CrossRefGoogle ScholarPubMed
Shimizu, H, Shimomura, Y, Nakanishi, Y, Futawatari, T, Ohtani, K, Sato, N & Mori, M (1997) Estrogen increases in vivo leptin production in rats and human subjects. Journal of Endocrinology 154, 285–292.CrossRefGoogle ScholarPubMed
Spicer, LJ & Francisco, CC (1997) The adipose obese gene product, leptin: evidence of a direct inhibitory role in ovarian function. Endocrinology 138, 3374–3379.CrossRefGoogle ScholarPubMed
Stephens, TW, Basinski, M, Bristow, PK, Buevalleskey, JM, Burgett, SG, Craft, L, Hale, J, Hoffman, J, Hsiung, HM, Kriauciunas, A, Mackellar, W, Rosteck, PR, Schoner, B, Smith, D, Tinsley, FC, Zhang, XY & Heiman, M (1995) The role of neuropeptide-Y in the antiobesity action of the obese gene-product. Nature 377, 539–532.CrossRefGoogle ScholarPubMed
Stewart, D (1992) Reproductive functions in eating disorders. Annals of Medicine 24, 287–291.CrossRefGoogle ScholarPubMed
Tartaglia, LA, Dembski, M, Weng, X, Deng, NH, Culpepper, J, Devos, R, Richards, GJ, Campfield, LA, Clark, FT, Deeds, J, Muir, C, Sanker, S, Moriarty, A, Moore, KJ, Smutko, JS, Mays, GG, Woolf, EA, Monroe, CA & Tepper, RI (1995) Identification and expression cloning of a leptin receptor, Ob-R. Cell 83, 1263–1271.CrossRefGoogle ScholarPubMed
Tomimatsu, T, Yamaguchi, M, Murakami, T, Ogura, K, Sakata, M, Mitsuda, N, Kanzaki, T, Kurachi, H, Irahara, M, Miyake, A, Shima, K, Aono, T & Murata, Y (1997) Increase of mouse leptin production by adipose tissue after midpregnancy: gestational profile of serum leptin concentration. Biochemical and Biophysical Research Communications 240, 213–215.CrossRefGoogle ScholarPubMed
Trayhurn, P, Hardie, LJ, Hoggard, N & Rayner, DV (1998) Regulation of leptin production. In Leptin – the Voice of the Adipose Tissue, pp. 69–77 [Blum, WF, Kiess, W and Rasher, W, editors]. Heidelberg, Germany: J.A. Barth Verlag.Google Scholar
Van der spuy, Z (1985) Nutrition and reproduction. Clinical Obstetrics and Gynaecology 12, 579–604.CrossRefGoogle ScholarPubMed
Yu, WH, Kimura, M, Walczewska, A, Karanth, S & McCann, SM (1997) Role of leptin in hypothalamic-pituitary function. Proceedings of the National Academy of Sciences USA 94, 1023–1028.CrossRefGoogle ScholarPubMed
Zachow, RJ & Magoffin, DA (1997) Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells. Endocrinology 138, 847–850.CrossRefGoogle ScholarPubMed