Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-27T03:17:12.613Z Has data issue: false hasContentIssue false
  • English
  • Français

Is vitamin A consumption a risk factor for osteoporotic fracture?

Published online by Cambridge University Press:  07 March 2007

Margo E. Barker  and
Aubrey Blumsohn
Margo E. Barker*
Affiliation:
Human Nutrition Unit1 and Bone Metabolism Unit2, Division of Clinical Sciences (North), University of Sheffield, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
Aubrey Blumsohn
Affiliation:
Human Nutrition Unit1 and Bone Metabolism Unit2, Division of Clinical Sciences (North), University of Sheffield, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
*
*Corresponding author: Dr Margo E. Barker, fax +44 114 261 0112, [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Severe vitamin A toxicity is known to have adverse effects on skeletal health. Studies involving animal models and case reports have documented that hypervitaminosis A is associated with bone resorption, hypercalcaemia and bone abnormalities. More recently, some epidemiological studies have suggested that high habitual intake of vitamin A could contribute to low bone mineral content and fracture risk. The evidence relating to the possible deleterious role of vitamin A in bone health is of variable quality and is potentially confounded by collinearity of nutrient intake and difficulties in assessing vitamin A exposure. Furthermore, because intake of vitamin A varies between studies it is not possible to define an intake threshold associated with harm.

Keywords

Vitamin A intakeHypervitaminosis ABone healthOsteoporotic fracture risk
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 4 , November 2003 , pp. 845 - 850
Copyright
Copyright © The Nutrition Society 2003

References

Anderson, JJB (2002) Oversupplementation of vitamin A and osteoporotic fractures in the elderly: To supplement or not to supplement with vitamin A. Journal of Bone and Mineral Research 17, 1359–1362.CrossRefGoogle ScholarPubMed
Ballew, C, Galuska, D & Gillespie, C (2001) High serum retinyl esters are not associated with reduced bone mineral density in the third National Health and Nutrition Examination Survey, 1988–1994. Journal of Bone and Mineral Research 16, 2306–2312.CrossRefGoogle Scholar
Bendich, A & Langseth, L (1989) Safety of vitamin A. American Journal of Clinical Nutrition 49, 358–371.CrossRefGoogle ScholarPubMed
Clarke, I & Bassett, AL (1962) The amelioration of hypervitaminosis D in rats with vitamin A. Journal of Experimental Medicine 115, 147–155.CrossRefGoogle Scholar
Dawson-Hughes, B (2003) Interaction of dietary calcium and protein in bone health in humans. Journal of Nutrition 133, 852S–854S.CrossRefGoogle ScholarPubMed
Denke, MD (2002) Dietary retinol – a double-edged sword. Journal of the American Medical Association 287, 102–104.CrossRefGoogle ScholarPubMed
Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects no. 41. London: H.M. Stationery Office.Google Scholar
Feskanich, D, Singh, V, Willett, WC & Colditz, GA (2002) Vitamin A intake and hip fractures among postmenopausal women. Journal of the American Medical Association 287, 47–54.CrossRefGoogle ScholarPubMed
Frame, B, Jackson, CE, Reynolds, WA & Umphrey, JE (1974) Hypercalcemia and skeletal effects in chronic hypervitaminosis A. Annals of Internal Medicine 80, 44–48.CrossRefGoogle ScholarPubMed
Frankel, TL, Seshadri, MS, McDowall, DB & Cornish, CJ (1986) Hypervitaminosis A and calcium-regulating hormones in the rat. Journal of Nutrition 116, 578–587.CrossRefGoogle ScholarPubMed
Goodman, AB (1995) Chromosomal locations and modes of action of genes of the retinoid (vitamin A) system support their involvement in the etiology of schizophrenia. American Journal of Medical Genetics 60, 335–348.CrossRefGoogle ScholarPubMed
Gregory, J, Foster, K, Tyler, H & Wiseman, M (1990) The Dietary and Nutritional Survey of British Adults. London: H.M. Stationery Office.Google Scholar
Harrington, M & Cashman, KD (2003) High salt intake appears to increase bone resorption in postmenopausal women but high potassium intake ameliorates this adverse effect. Nutrition Reviews 61, 179–163.Google ScholarPubMed
Hough, S, Avioli, LV, Muir, H, Gelderblom, D, Jenkins, G, Kurasi, H, Slatopolsky, E, Bergfeld, MA & Teitelbaum, SL (1988) Effects of hypervitaminosis A on the bone and mineral metabolism of the rat. Endocrinology 122, 2933–2966.CrossRefGoogle ScholarPubMed
Hulshof, P, Brouwer, JT, Burema, J & West, CE (2002) Bias and random error in retinol measurements of laboratories in countries with populations with mild to severe vitamin A deficiency. Clinical Chemistry 48, 2061–2063.CrossRefGoogle ScholarPubMed
Institute of Medicine (2000) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. >Washington DC: National Academy Press.Washington+DC:+National+Academy+Press.>Google Scholar
Johansson, S & Melhus, H (2001) Vitamin A antagonizes calcium response to vitamin D in man. Journal of Bone and Mineral Research 16, 1899–1905.CrossRefGoogle ScholarPubMed
Kawahara, TN, Krueger, DC, Engelke, JA, Harke, JM & Binkley, NC (2002) Short-term vitamin A supplementation does not affect bone turnover in men. Journal of Nutrition 132, 1169–1172.CrossRefGoogle Scholar
Melhus, H, Michaelsson, K, Kindmark, A, Bergstrom, R, Holmberg, L, Mallmin, H, Wolk, A & Ljunghall, S (1998) Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk of hip fracture. Annals of Internal Medicine 129, 770–778.CrossRefGoogle ScholarPubMed
Metz, AL, Walser, MM & Olson, WG (1985) The interaction of dietary vitamin A and vitamin D related to skeletal development in the turkey poult. Journal of Nutrition 115, 929–935.CrossRefGoogle ScholarPubMed
Michaelsson, MD, Lithell, H, Vessby, B & Melhus, H (2003) Serum retinol levels and risk of fracture. New England Journal of Medicine 348, 287–294.CrossRefGoogle ScholarPubMed
Milstone, LM & Leachman, SA (2001) Do retinoids cause osteoporosis? In Nutritional Aspects of Osteoporosis, pp. 285–293 [Burckhardt, P, Dawson-Hughes, B and Heaney, RP, editors]. New York: Academic Press.Google Scholar
Moore, T & Sharman, IM (1979) Hypervitaminosis A combined with calcium deficiency in rats. International Journal of Vitamin and Nutrition Research 49, 14–20.Google ScholarPubMed
Promislow, JHE, Goodman-Gruen, D, Slymen, DJ & Barrett-Connor, E (2002) Retinol intake and bone mineral density in the elderly: the Rancho Bernardo Study. Journal of Bone and Mineral Research 17, 1349–1358.CrossRefGoogle ScholarPubMed
Rohde, CM & DeLuca, H (2003) Bone resorption activity of all-trans retinoic acid is independent of vitamin D in rats. Journal of Nutrition 133, 777–783.CrossRefGoogle ScholarPubMed
Rohde, CM, Puno, CWE, Manatt, M, Clagett-Dame, M & Deluca, HF (1999) Vitamin A antagonises the action of vitamin D in rats. Journal of Nutrition 129, 2246–2250.CrossRefGoogle Scholar
Sigurdsson, G, Franzson, L, Thorgeirsdottir, H & Steingrimsdottir, L (2001) A lack of association between excessive dietary intake of vitamin A and bone mineral density in seventy-year-old Icelandic women. In Nutritional Aspects of Osteoporosis, pp. 295–302 [Burckhardt, P, Dawson-Hughes, B and Heaney, RP, editors]. New York: Academic Press.Google Scholar
Smith, FR & Goodman, DS (1976) Vitamin A transport in human vitamin A toxicity. New England Journal of Medicine 294, 805–808.CrossRefGoogle ScholarPubMed
Sowers, MF & Wallace, RB (1990) Retinol, supplemental vitamin A and bone status. Journal of Clinical Epidemiology 43, 693–699.CrossRefGoogle ScholarPubMed
Stephensen, CB & Gildengorin, G (2000) Serum retinol, the acute phase response, and the apparent misclassification of vitamin A status in the third National Health and Nutrition Examination Survey. American Journal oj'Clinical Nutrition 72, 1170–1178.CrossRefGoogle ScholarPubMed
West, CE, Eilander, A & Van Lieshout, M (2002) Consequences of revised estimates of carotenoid bioefficacy for dietary control of vitamin A deficiency in developing countries. Journal of Nutrition 132, 2920S–2926S.CrossRefGoogle ScholarPubMed
Willett, W (1998) Nutritional Epidemiology, 2nd ed. New York: Oxford University Press.CrossRefGoogle Scholar
Willett, WC, Stampfer, MJ, Underwood, BA, Taylor, JO & Hennekens, CH (1983) Vitamins A, E, and carotene: Effects of supplementation on their plasma levels. American Journal of Clinical Nutrition 38, 559–566.CrossRefGoogle Scholar