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Is there a role for dietary salicylates in health?*

Published online by Cambridge University Press:  07 March 2007

John Paterson
Affiliation:
Dumfries and Galloway Royal Infirmary, Bankhead Road, Dumfries DG1 4AP, UK
Gwen Baxter
Affiliation:
Dumfries and Galloway Royal Infirmary, Bankhead Road, Dumfries DG1 4AP, UK
James Lawrence
Affiliation:
Dumfries and Galloway Royal Infirmary, Bankhead Road, Dumfries DG1 4AP, UK
Garry Duthie*
Affiliation:
Rowett Research Institute, Greenburn Road, Aberdeen AB21 9SB, UK
*
Corresponding author: Professor Garry Duthie, fax +44 1224 716629, email [email protected]
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Abstract

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Acetylsalicylic acid (aspirinTM; 2-acetoxybenzoic acid) has been used for >100 years for pain relief and to treat inflammatory conditions and fevers. More recently, regular intake has been associated with decreased incidence of certain cancers, particularly colon cancer. After absorption aspirin is very rapidly hydrolysed to salicylic acid (2-hydroxybenzoic acid). The anti-cancer effects of aspirin may be a result of salicylic acid reducing the transcription of prostaglandin H2-synthase and thereby the synthesis of pro-inflammatory and potentially-neoplastic prostaglandins. Salicylic acid is widely present in plants and functions as a hormonal mediator of the systemic acquired resistance response to pathogen attack and environmental stress. Thus, it is present in a large range of fruit, vegetables, herbs and spices of dietary relevance. Consequently, the recognised effect of consuming fruit and vegetables on lowering risk of colon cancer may be partly attributable to salicylates in plant-based foods. The present review discusses which types of fruit and vegetables are the richest source of salicylates and whether they are sufficiently released from the food matrix to modify the key cellular events associated with the pathogenesis of colon cancer.

Type
Symposium on ‘Phytochemicals’
Copyright
Copyright © The Nutrition Society 2006

Footnotes

*

This paper is dedicated to the memory of john paterson.

References

Anon (1903) Salicylic acid in strawberries. Lancet ii 1187.Google Scholar
Baron, JA, Cole, BF, Sandler, RS, Haile, RW, Ahnen, D, Bresalier, R et al. (2003) A randomised trial of aspirin to prevent colorectal adenomas. New England Journal of Medicine 348 891899.CrossRefGoogle ScholarPubMed
Baxter, GJ, Graham, AB, Lawrence, JR, Wiles, D & Paterson, JR (2001) Salicylic acid in soups prepared from organically- and non-organically grown vegetables. European Journal of Nutrition 40 289292.CrossRefGoogle ScholarPubMed
Baxter, GJ, Lawrence, JR, Graham, AB, Wiles, D & Paterson, JR (2002) Identification and determination of salicylic acid and salicyluric acid in urine of people not taking salicylate drugs. Annals of Clinical Biochemistry 39 5055.CrossRefGoogle Scholar
Baxter, G, Paterson, J, Wiles, D, Graham, A & Shirastava, R (2005) Salicylic acid: the spice of life? Proceedings of the Nutrition Society 64 64A.Google Scholar
Benamouzig, R, Deyra, J, Martin, A, Girard, B, Jullian, E, Piednoir, B, Couturier, D, Coste, T, Little, J & Chaussade, S (2003) Daily soluble aspirin and prevention of colorectal adenoma recurrence: one year results of the APACC trial. Gastroenterology 125 328336.CrossRefGoogle ScholarPubMed
Blacklock, CJ, Lawrence, JR, Wiles, D, Malcolm, EA, Gibson, IH, Kelly, CJ & Paterson, JR (2001) Salicylic acid in the serum of subjects not taking aspirin. Comparison of salicylic acid concentrations in the serum of vegetarians, non-vegetarians, and patients taking low dose aspirin. Journal of Clinical Pathology 54 553555.CrossRefGoogle Scholar
Bosetti, C, Gallus, S, La Vecchia, C (2001) Aspirin and cancer risk: an update to 2001. European Journal of Cancer Prevention 11 535542.CrossRefGoogle Scholar
Craven, PA & DeRubertis, FR (1992) Effects of aspirin on 1,2-dimethylhydrazine-induced colonic carcinogenesis. Carcinogenesis 13 541546.CrossRefGoogle Scholar
Davidson, C (1971) Salicylate metabolism in man. Annals of the New York Academy of Sciences 179 249268.CrossRefGoogle Scholar
Duthie, GG, Gardner, PT & Kyle, JAM (2003) Plant polyphenols: are they the new magic bullet? Proceedings of the Nutrition Society 62 599603.CrossRefGoogle ScholarPubMed
Duthie, GG, Kyle, JAM, Jenkinson, AM, Duthie, SJ, Baxter, GJ & Paterson, JR (2005) Increased salicylate concentration in urine of human volunteers after consumption of cranberry juice. Journal of Agricultural and Food Chemistry 53 28972900.CrossRefGoogle ScholarPubMed
Fenoglio-Preiser, CM & Noffsinger, A (1999) Aberrant crypt foci: A review. Toxicologic Pathology 27 632642.CrossRefGoogle ScholarPubMed
Hare, LG, Woodside, JV & Young, IS (2003) Dietary salicylates. Journal of Clinical Pathology 56 649650.CrossRefGoogle ScholarPubMed
Hawk, LG, Umar, A & Viner, JL (2004) Colorectal cancer chemoprevention – An overview of the science. Gastroenterology 128 14231447.CrossRefGoogle Scholar
Janssen, PLTMK, Hollman, PCH, Reichman, E, Venema, DP, van Staveren, WA & Katan, MB (1996) Urinary salicylate excretion in subjects eating a variety of diets shows that the amount of bio-available salicylates is low. American Journal of Clinical Nutrition 64 743747.CrossRefGoogle Scholar
Jeffreys, D (2004) Aspirin: The Story of a Wonder Drug. London: Bloomsbury Publishing.Google Scholar
Lawrence, JR, Peter, R, Baxter, GJ, Robson, J, Graham, AB & Paterson, JR (2003) Urinary excretion of salicyluric and salicylic acids in non-vegetarians, vegetarians and patients taking low dose aspirin. Journal of Clinical Pathology 56 651653.CrossRefGoogle ScholarPubMed
Mahmoud, MN, Dannenberg, AJ, Mestre, J, Bilinski, RT, Churchill, MR, Martucci, C, Newmark, H & Bertagnolli, MM (1998) Aspirin prevents tumors in a murine model of familial adenomatous polyposis. Surgery 124 225231.CrossRefGoogle Scholar
Needs, CJ & Brooks, PM (1985) Clinical pharmacokinetics of the salicylates. Clinical Pharmacokinetics 10 164177.CrossRefGoogle ScholarPubMed
Nordic Committee on Food Analysis (1999) Salicylic Acid in Foods. Qualitative and Quantitative Analysis, NMKL Method no. 3, 3rd ed. Oslo, Norway: NMKL.Google Scholar
Paterson, JR, Blacklock, C, Campbell, G, Wiles, D & Lawrence, JR (1998) The identification of salicylates as normal constituents of serum: A link between diet and health? Journal of Clinical Pathology 51 502505.CrossRefGoogle ScholarPubMed
Paterson, JR & Lawrence, JR (2001) Salicylic acid: a link between aspirin, diet and the prevention of colorectal cancer. Quarterly Journal of Medicine 94 445448.CrossRefGoogle ScholarPubMed
Pierpoint, WS (2002) Can aspirin help identify leaf proteins active in defence responses? Annals of Applied Biology 140 233239.CrossRefGoogle Scholar
Radtke, J, Linseisen, J & Wolfram, G (1998) Phenolic acid intake of adults in a Bavarian subgroup of the national food consumption survey. Zeitschrift für Ernahrungswissenschaft 37 190197.Google Scholar
Reddy, BS, Rao, CV, Rivenson, A & Kellof, G (1993) Inhibitory effect of aspirin onazoxymethane-induced colon carcinogenesis in F344 rats. Carcinogenesis 14 14931497.CrossRefGoogle ScholarPubMed
Riboli, E & Norat, T (2003) Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. American Journal of Clinical Nutrition 78 559S569S.CrossRefGoogle ScholarPubMed
Robertson, GL & Kermode, WJ (1981) Salicylic acid in fresh and canned fruit and vegetables. Journal of the Science of Food and Agriculture 32 833836.CrossRefGoogle Scholar
Sandler, RS, Halabi, S, Baron, JA, Budinger, S, Paskett, E, Keresztes, R et al. (2003) A randomised trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. New England Journal of Medicine 348 883890.CrossRefGoogle ScholarPubMed
Scottish Collaborative Group (2005) Scottish Collaborative Group food frequency questionnaire. http://www.food frequency.org.Google Scholar
Shpitz, B, Bomstein, Y, Kariv, N, Shalev, M, Buklan, G & Bernheim, J (1998) Chemopreventative effect of aspirin on growth of aberrant crypt foci in rats. International Journal of Colorectal Diseases 13 169172.CrossRefGoogle Scholar
Shpitz, B, Klein, E, Buklan, G, Neufield, D, Nissan, A, Freund, HR, Grankin, M & Berheim, J (2003) Suppressive effect of aspirin on aberrant crypt foci in patients with colorectal cancer. Gut 52 15981601.CrossRefGoogle ScholarPubMed
Swain, AR, Dutton, SP & Truswell, AS (1985) Salicylates in foods. Journal of the American Dietetic Association 85 950960.CrossRefGoogle ScholarPubMed
Venema, DP, Hollman, PCH, Janssen, PLTMK & Katan, MB (1996) Determination of acetylsalicylic acid and salicylic acid in foods using HPLC with fluorescence detection. Journal of Agriculture and Food Chemistry 44 17621767.CrossRefGoogle Scholar
Wood, A, Baxter, G, Paterson, J, Thies, F & Duthie, G (2005) Comparison of methods to determine salicylic acid content of fruit juices. Proceedings of the Nutrition Society 64 87A.Google Scholar
Wu, KK (2000) Aspirin and salicylate – an old remedy with a new twist. Circulation 102 20222023.CrossRefGoogle ScholarPubMed
Xu, XM, Sanores-Garcia, L, Chen, XM, Matijevic-Aleksic, N, Du, M & Wu, KK (1999) Suppression of inducible cyclo-oxygenase 2 gene transcription by aspirin and sodium salicylate. Proceedings of the National Academy of Sciences USA 96 52925297.CrossRefGoogle ScholarPubMed