Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-05T11:02:59.778Z Has data issue: false hasContentIssue false

Fortification strategies to meet micronutrient needs: sucesses and failures

Published online by Cambridge University Press:  27 March 2009

Ian Darnton-Hill*
Affiliation:
World Health Organization, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland
Ritu Nalubola
Affiliation:
US Food and Drug Administration, Washington, DC, USA
*
*Ian Darnton-Hill, present address 111 East 14th Street, #190, New York, NY 10003, USA, fax +41 22 791 4186, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Food fortification is likely to have played an important role in the current nutritional health and well-being of populations in industrialized countries. Starting in the early part of the 20th century, fortification was used to target specific health conditions: goitre with iodized salt; rickets with vitamin D-fortified milk; beriberi, pellagra and anaemia with B-vitamins and Fe-enriched cereals; more recently, in the USA, risk of pregnancy affected by neural-tube defects with folic acid-fortified cereals. A relative lack of appropriate centrally-processed food vehicles, less-developed commercial markets and relatively low consumer awareness and demand, means it has taken about another 50 years for fortification to be seen as a viable option for the less-developed countries. The present paper reviews selected fortification initiatives in developing countries to identify different factors that contributed to their successful implementation, as well as the challenges that continually threaten the future of the se programmes. Ultimately, the long-term sustainability of fortification programmes is ensured when consumers are willing and able to bear the additional cost of fortified foods. There has been an enormous increase in fortification programmes over the last couple of decades in developing countries. Considerable progress has been made in reducing vitamin A and I deficiencies, although less so with Fe, even as Zn and folic acid deficiencies are emerging as important public health problems. Food fortification based on sound principles and supported by clear policies and regulations can play an increasingly large role in this progress towards prevention and control of micronutrient malnutrition.

Type
International and Public Health Nutrition Group Symposium on ‘Achieving a balanced diet in the developing world: strategies to meet micronutrient needs’
Copyright
Copyright © The Nutrition Society 2002

References

Arroyave, G, Aguilar, J, Flores, M & Guzman, MA (1979) Evaluation of Sugar Fortification with Vitamin A at the National Level. Washington, DC: PAHO.Google Scholar
Ash, DM, Latham, MC, Tatala, SR, Mehansho, H, Ndossi, N & Frongillo, EA Jr (1999) Trial of a micronutrient fortified beverage supplement in school children and pregnant women in Tanzania. XIXth IVACG Report Vitamin A and other Micronutrients: Biologic Interactions and Integrated Interventions, W23:90Abstr. Washington, DC: IVACG/USAID/ILSI Research Foundation.Google Scholar
Asian Development Bank/Micronutrient Initiative/International Life Sciences Institute (2000) Consensus Statement of the Manila Forum on Food Fortification Policy. Manila, The Philippines: Asian Development Bank.Google Scholar
Beard, J (1996) Iron fortification in Venezuela. American Journal of Clinical Nutrition 64, 972973.Google Scholar
Bishai, D & Nalubola, R (2002) The history of food fortification in the United States: its relevance for current fortification efforts in developing countries. Economic Development and Cultural Change (In the Press).CrossRefGoogle Scholar
Bürgi, H (1998) Iodine deficiency disorders in Switzerland. In Elimination of Iodine Deficiency Disorders (IDD) in Central and Eastern Europe, the Commonwealth of Independent States, and the Baltic States. WHO/EURO/NUT/98.1, pp. 1519 [Delange, F, Robertson, A, McLoughney, E and Gerasimov, G, editors]. Geneva: WHO.Google Scholar
Caudill, MA, Le, T, Moonie, SA, Torabian, Esfahani S & Cogger, EA (2001) Folate status in women of childbearing age residing in Southern California after folic acid fortification. Journal of the American College of Nutrition 20, 129134.CrossRefGoogle ScholarPubMed
Center for Disease Control (2001) CDC Press Release (06 19, 2001) Neural Tube Birth Defects Down by 19 Percent Since Food Fortification. Fortification, Educational Outreach and More Awareness May Contribute to Decline. Atlanta, GA: CDC.Google Scholar
Darnton-Hill, I (1989) Vitamin A fortification of wheat: Bangladesh experience. Latest Advances in the Control of Vitamin A Deficiency and its Impact on Health. Government of Indonesia/WHO, SEARO/HKI. Report of a Regional Workshop pp. 121135 Bogor, Indonesia: Nutrition Research and Development Centre.Google Scholar
Darnton-Hill, I (1998) Overview: rationale and elements of a successful food-fortification programme. Food and Nutrition Bulletin 19, 92100.CrossRefGoogle Scholar
Darnton-Hill, I, Mora, JO, Weinstein, H, Wilbur, S & Nalubola, PR (1999) Iron and folate fortification in the Americas to prevent and control micronutrient malnutrition: an analysis. Nutrition Reviews 57, 2531.Google Scholar
Dary, O (2001) Free Trade vs Public Health: the history of the fighting for the sugar fortification program in Guatemala. XXth, IVACG Report 25 Years of Progress in Controlling Vitamin A Deficiency: Looking to the Future, W5:59 Abstr. Washington, DC: IVACG/USAID/ILSI Research Foundation.Google Scholar
Delange, F (1998) Monitoring of programmes of correction of IDD. In Elimination of Iodine Deficiency Disorders (IDD) in Central and Eastern Europe, the Commonwealth of Independent States, and the Baltic States. WHO/EURO/NUT/98.1, pp. 103116 [Delange, F, Robertson, A, McLoughney, E and Gerasimov, G, editors]. Geneva: WHO.Google Scholar
Ferrer, F (2001) VivaLeite program improves Brazilian children's quality of life. Nutriview 2, 3.Google Scholar
Fidler, M, Davidsson, L, Walczyk, T & Hurrell, R (2001) Iron bioavailability from iron fortified fish sauce and soy sauce. XXth IVACG Report 25 Years of Progress in Controlling Vitamin A Deficiency: Looking to the Future, F40:28 Abstr. Washington, DC: IVACG/USAID/ILSI Research Foundation.Google Scholar
Food and Agriculture Organization (1996) Food Fortification: Technology and Quality Control. Report of an FAO Technical Meeting, Rome, 20–23 November 1995. FAO Food and Nutrition Paper. Rome: FAO.Google Scholar
Gerasimov, G & Delange, F (1998) Overview of iodine deficiency disorders (IDD) and their control programmes in Eastern Europe and Central Asia. In Elimination of Iodine Deficiency Disorders (IDD) in Central and Eastern Europe, the Common-wealth of Independent States, and the Baltic States. WHO/EURO/NUT/98.1, pp. 713 [Delange, F, Robertson, A, McLoughney, E and Gerasimov, G, editors]. Geneva: WHO.Google Scholar
Harvey, PWJ, Dexter, PB & Darnton-Hill, I (2000) The impact of consuming iron from non-food sources on iron status in developing countries. Public Health Nutrition. 3: 375383.Google Scholar
Hollowell, JG, Staehling, NW, Hannon, WH, Flanders, DW, Gunter, EW, Maberly, GF, Braverman, LE, Pino, S, Miller, DT, Garbe, PL, DeLozier, DM & Kackson, RJ, (1998) Iodine nutrition in the United States. Trends and public health implications: iodine excretion data from the National Health and Nutrition Examination Surveys I and III (1971–1974 and 1988–1994). Journal of Clinical Endocrinology and Metabolism. 83: 34013408.Google Scholar
Honein, MA, Paulozzi, LJ, Mathews, TJ, Erickson, JD & Wong, L-YC, (2001) Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. Journal of the American Medical Association. 285: 29812986.CrossRefGoogle ScholarPubMed
Huffman, SL, Baker, J, Shumann, J & Zehner, ER (1998) The Case for Promoting Multiple Vitamin/Mineral Supplements for Women in Underdeveloped Countries. Washington, DC: LINKAGES Project/USAID. AED/PSI.Google Scholar
Institute of Medicine (1998) Prevention of Micronutrient Deficiencies: Tools for Policy Makers and Public Health Workers. Summary and Key Elements [Howson, CP, Kennedy, ET and Horwitz, A, editors]. Washington, DC: National Academy Press.Google Scholar
International Council for the Control of the Iodine Deficiency Disorders (2000a) Salt 2000: marking and sustaining global progress in Universal Salt Iodization. IDD Newsletter. 16: 3437.Google Scholar
International Council for the Control of the Iodine Deficiency Disorders (2000b) Reports from the Regions. Africa. IDD Newsletter. 16: 2528.Google Scholar
Johnson, Q (2000) Fortifying flour to improve world health. World Grain. 11 issue. Bangkok: World Grain Co. Ltd. www.worldgrain.comGoogle Scholar
Layrisse, M, Chavez, JF, Mendez-Castellano, H, Bosch, V, Tropper, E, Bastardo, B & Gonzalez, E, (1996) Early response to the effect of iron fortification in the Venezuelan population. American Journal of Clinical Nutrition. 64: 903907.CrossRefGoogle Scholar
Lindsey, D & Kwaramba, T, (2001) Making hammermill fortification at community level work. Nutriview. 2: 2.Google Scholar
Lotfi, M, Mannar, MGV, Merx, RJHM & Naber-van den, Heuvel P (1996) Micronutrient Fortification of Foods: Current Practices, Research, and Opportunities.Ottawa, Ont.: MI/IAC.Google Scholar
McNulty, H (1999) Towards improving dietary intakes and health: the contribution of fortified foods. Scandinarian Journal of Nutrition. 43, Suppl. 35, 106S111S.Google Scholar
Mason, J, Hunt, J, Parker, D & Jonsson, U (1999) Investing in child nutrition in Asia. Asian Development Review. 17, 132.CrossRefGoogle Scholar
Mason, JB, Lotfi, M, Dalmiya, N, Sethuramanan, K & Deitchler, M (2001) The Micronutrient Report: Current Progress and Trends in the Control of Vitamin A, Iodine and Iron Deficiencies. Tulane University/MI/UNICEF.Ottawa, Ont.: Micronutrient Initiative.Google Scholar
Melse-Boonstra, A, de Pee, S, Martini, E, Halati, S, Sari, M, Kosen, S, Muhilal, & Bloem, MW (2000) The potential of various foods to serve as a carrier for micronutrient fortification, data from remote areas in Indonesia. European Journal of Clinical Nutrition. 54, 822827.CrossRefGoogle ScholarPubMed
Meng, W & Schindler, A (1998) Iodine supply in Germany. In Elimination of Iodine Deficiency Disorders (IDD) in Central and Eastern Europe, the Commonwealth of Independent States, and the Baltic States. WHO/EURO/NUT/98.1, pp. 2130 [Delange, F, Robertson, A, McLoughney, E and Gerasimov, G, editors]. Geneva: WHO.Google Scholar
Micronutrient Initiative (1997) Food Fortification to End Micronutrient Malnutrition: State of the Art. Ottawa, Ont: Micronutrient Initiative.Google Scholar
Micronutrient Initiative/UNICEF/International Sugar Organization/USAID/Swaziland Sugar Association (1999) Sugar Fortification to End Vitamin A Deficiency in Southern and Eastern Africa. Report of a Public/Private Sector Dialogue, Ezulwini, Swaziland. Ottawa, Ont: Micronutrient Initiative.Google Scholar
Mora, JO, Dary, O, Chinchilla, D & Arroyave, G (2000) Vitamin A Sugar Fortification in Central America. Experiences and Lessons Learned. Washington, DC: MOST/USAID/INCAP/PAHO.Google Scholar
Muhilal, , Permesieh, D, Idjaradimata, Y, Muherdiyantingsih, & Karyadi, D (1988) Vitamin A-fortified monosodium glutamate and health, growth and survival of children: a controlled trial. American Journal of Clinical Nutrition. 48, 12711276.Google Scholar
Murphy, PA (1996) Technology of vitamin A fortification of foods in developing countries. Food Tecnology. 50, 6974.Google Scholar
Nalubola, R (2000) Safety of Vitamin A Fortification of Foods: a brief review. Washington, DC: MOST/USAID.Google Scholar
Nathan, R (2000) Regulation of Fortified Foods to Address Micronutrient Malnutrition: Legislation, Regulations, and Enforcement. Ottawa, Ont.: Micronutrient Initiative.Google Scholar
Nestel, P (1993) Food Fortification in Developing Countries. New York: USAID/VITAL..Google Scholar
Nutriview, R (2000) Nutriview Special Issue. Mandatory Food Enrichment. Basel: Roche Vitamins Europe Ltd.Google Scholar
Nutriview, R (2001) Food fortification gains support in Africa. Nutriview Newsletter, vol. 1, p. 3. Basel: Roche Vitamins Europe Ltd.Google Scholar
Ong, ASH (1994) Nutritional aspects of palm oil: an introductory review. Asia Pacific Clinical Nutrition. 3, 201206.Google Scholar
Park, YK, Sempos, CT, Barton, CN, Vanderveen, JE & Yetley, EA (2000) Effectiveness of food fortification in the United States: the case of pellagra. American Journal of Public Health. 90, 727738.Google ScholarPubMed
Sari, M, Bloem, MW, de Pee, S, Schultink, WJ & Sastroamidjojo, S (2001) Effect of iron-fortified candies on the iron status of children aged l–4y in East Jakarta, Indonesia. American Journal of Clinical Nutrition. 72, 10341039.Google Scholar
Serra-Majem, L (2001) Vitamin and mineral intakes in European children. Is food fortification needed?. Public Health Nutrition. 4, 101107.Google Scholar
Solomons, NW (1998) Plant sources of vitamin A and human nutrition: red palm oil does the job. Nutrition Reviews. 56, 309311.CrossRefGoogle ScholarPubMed
Solon, FS, Bermardo, ABI, Sarol, JN, Solon, JA, Mehanso, H, Fermin, LS & Wambangco, (2001) The effect of a multiple micronutrient fortified fruit drink with and without antihelmentic therapy on growth, fitness and mental ability of Filipino school children.. XXth IVACG Report 25 Years of Progress in Controlling Vitamin A Deficiency: Looking to the Future. F41: 28 Abstr. Washington, DC: IVACG/USAID/ILSI Research Foundation.Google Scholar
Solon, FS, Klemm, RDW, Sanchez, L, Damton-Hill, I, Craft, NE, Christian, P & West, KP Jr (2000) Efficacy of a vitamin A-fortified wheat-flour bun on the vitamin A status of Filipino schoolchildren. American Journal of Clinical Nutrition. 72, 738–734.Google Scholar
Solon, FS, Solon, MS, Mehansho, H, West, KP Jr, Sarol, J, Perfecto, C, Nano, T, Sanchez, L, Isleta, M, Wasantwisut, E & Sommer, A (1996) Evaluation of the effect of vitamin A-fortified margarine on the vitamin A status of pre-school Filipino children. European Journal of Clinical Nutrition. 56, 720723.Google Scholar
Thuy, PV, Berger, J, Davidson, L, Khan, NC, Nga, TT, Lam, NT, Mai, TT, Flowers, C, Nakanish, Y, Cook, JD, Hurrel, RF & Khoi, HH (2001) Regular consumpton of NaFeEDTA fortified fish sauce improves hemoglobin in anemic Vietnamese women. XXth IVACG Report 25 Years of Progress in Controlling Vitamin A Deficiency: Looking to the Future, F47: 30Abstr. Washington, DC: IVACG/USAID/ILSI Research Foundation.Google Scholar
Todd, CH, Ammain, T, Gomo, ZAR, Hasker, JA, Ndiweni, M & Oken, E (1995) Increase in thyrotoxicosis associated with iodine supplements in Zimbabwe. Lancet. 346, 15631564.Google Scholar
UNICEF (1990) World Declaration on the Survival, Protection and Development of Children. The World Summit for Children. New York: UNICEF.Google Scholar
UNICEF/World Health Organization/United Nations University (1999) Composition of a Multi-micronutrient Supplement to be Used in Pilot Programmes Among Pregnant Women in Developing Countries. New York: UNICEF.Google Scholar
van Stuijvenberg, ME, Kvalsvig, JD, Faber, M, Voster, N & Benade, AJS (1997) The Hidden Hunger: Addressing Micronutrient Deficiencies in School Children. Medical Research Council of South Africa: Policy Briefs no. 4. Capetown, South Africa: Medical Research Council of South Africa.Google Scholar
World Bank (1993) Investing in Health. World Development Report 1993. New York: Oxford University Press.Google Scholar
World Health Organization (1995) Nutrition. Highlights of Recent Activities in the Context of the World Declaration and Plan of Action for Nutrition. Geneva: WHO.Google Scholar
Zlotkin, S, Arthur, P, Antwi, KY & Yeung, G (2001) Randomized controlled trial of microencapsulated ferrous fumarate ‘sprinkles’ and ferrous sulfate drops, for the treatment and prevention of anemia in Ghanaian infants. XXth IVACG Report 25 Years of Progress in Controlling Vitamin A Deficiency: Looking to the Future, F47: 30Abstr. Washington, DC: IVACG/USAID/ILSI Research Foundation.Google Scholar