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Ethnic Specific Differences in Cholesterol Trafficking Following High Fructose Feeding

Published online by Cambridge University Press:  15 April 2015

S. V. Harding  and
L. M. Goff
S. V. Harding
Affiliation:
Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, London, United Kingdom, SE1 9NH
L. M. Goff
Affiliation:
Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, London, United Kingdom, SE1 9NH
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Abstract

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Proceedings of the Nutrition Society , Volume 74 , Issue OCE1: Summer Meeting, 14–17 July 2014, Carbohydrates in health: friends or foes , 2015 , E36
Copyright
Copyright © The Authors 2015 

This study aimed to assess ethnic-specific impacts of fructose on cholesterol metabolism of black West-African (BA) and white European (WE) men. Fifteen healthy men (7 BA/8 WE) undertook 24-hrs controlled feeding (25% calories from fructose). Plasma cholesterol (TC), HDL, non-HDL, triglycerides (TG), red blood cell cholesterol (Chol), lathosterol (LS), campesterol (CS) and β-sitosterol (BS) concentrations were measured at baseline and 24hrs and changes assessed in each ethnicity by student and paired t-tests.

Baseline TC (5·13 ± 0·68 vs. 4·33 ± 0·58, p = 0·03) and non-HDL (3·75 ± 0·61 vs. 3·07 ± 0·51, p = 0·03) were higher in BA but there were no differences in HDL or TG. There were no significant lipid changes (TC + 0·21 mmol/L; non-HDL +0·18 mmol/L; HDL +0·03 mmol/L; TG +0·05 mmol/L) following fructose feeding in WE while BA TC (+0·38 mmol/L, p = 0·002), non-HDL (+0·30 mmol/L, p = 0·004) and HDL (+0·08 mmol/L, p = 0·02) increased. Baseline RBC Chol, LS, CS and BS were higher in BA compared to WE. The RBC Chol concentration following fructose was not different between ethnicities but did remain higher in BA (0·17 vs. 0·05 μmol/g RBC, p = 0·003). Changes between baseline and 24-hr for RBC Chol, LS, CS and BS are shown in Figure 1. The LS:Chol (mmol:mol chol) (5·6 vs. 4·2, p = 0·06) tended to be higher in BA suggesting a higher cholesterol synthesis. Finally, CS (0·54 vs. 0·08 nmol/g RBC, p = 0·02) and BS (0·34 vs. 0·06 nmol/g RBC, p = 0·008) concentrations were higher and the BS:Chol (1·9 vs. 1·2, p = 0·11) tended to be higher at 24hrs in BA, indicating higher cholesterol absorption. These data illustrate both ethnic specific differences in markers of cholesterol metabolism and a differential effect of fructose on these outcomes.

Fig. 1. Red blood cell sterol concentration changes at 24 hours folloeing high fructose feeding. Values are mean ± SEM. Significant differences from baseline within ethnicity are denoted by *. #Changes in lathosterol concentrations tended to be higher (p = 0.100) in Black West African men only, suggesting an increased cholesterol

Figure 0

Fig. 1. Red blood cell sterol concentration changes at 24 hours folloeing high fructose feeding. Values are mean ± SEM. Significant differences from baseline within ethnicity are denoted by *. #Changes in lathosterol concentrations tended to be higher (p = 0.100) in Black West African men only, suggesting an increased cholesterol