Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-22T15:58:29.322Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of prenatal diet and glucocorticoids on growth and systolic blood pressure in the rat

Published online by Cambridge University Press:  05 March 2007

David S. Gardner ,
Alan A. Jackson  and
Simon C. Langley-Evans
David S. Gardner*
Affiliation:
Division of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Alan A. Jackson
Affiliation:
Division of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Simon C. Langley-Evans
Affiliation:
Department of University Medicine, Level D South Block, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
*
*Correponding author: D. S. Gardner, Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK; 01223 333840 email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 57 , Issue 2 , May 1998 , pp. 235 - 240
Copyright
Copyright © The Nutrition Society 1998

References

Barker, DJP (1994) Mothers, Babies and Disease in Later Life. London: BMJ Publishing Group.Google Scholar
Barker, DJP, Gluckman, PD, Godfrey, KM, Harding, JE, Owens, JA &Robinson, JS (1993) Fetal nutrition and cardiovascular disease in adult life. Lancet 341, 938–941.Google Scholar
Barker, DJP &Osmond, C (1986) Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet i, 1077–1081.CrossRefGoogle Scholar
Barker, DJP, Osmond, C, Golding, J, Kuh, D & Wadsworth, MEJ (1989) Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. British Medical Journal 298, 564–567.Google Scholar
Benediktsson, R, Lindsay, R, Noble, J, Seckl, JR &Edwards, CRW (1993) Glucocorticoid exposure in utero: A new model for adult hypertension. Lancet 341, 339–341.CrossRefGoogle ScholarPubMed
Benediktsson, R, Noble, J, Calder, AA &Seckl, JR (1995) 11β-Hydroxysteroid dehydrogenase activity in intact dually-per-fused fresh human placenta predicts birth weight. Journal of Endocrinology 144, Suppl.,161.Google Scholar
Berry, C (1978) Hypertension and arterial development: long term considerations. British Heart Journal 40, 709–717.Google Scholar
Campbell, DM, Hall, MH, Barker, DJP, Cross, J, Shiell, AW& Godfrey, KM (1996) Diet in pregnancy and the offspring's blood pressure 40 years later. British Journal of Obstetrics and Gynaecology 103, 273–280.CrossRefGoogle ScholarPubMed
Chatelain, A, Dupouy, J-P &Allaume, P (1980) Fetal-maternal adrenocorticotrophin and corticosterone relationships in the rat: Effects of maternal adrenalectomy. Endocrinology 106, 1297– 1303.Google Scholar
Cooper, C, Kuh, D, Egger, P, Wadsworth, M &Barker, D (1996) Childhood growth and the age at menarche. Journal of Obstetrics and Gynaecology 103, 814–817.Google Scholar
Crowe, C, Dandekar, P, Fox, M, Dhingra, K, Bennet, L & Hanson, MA (1995) The effects of anaemia on heart, placenta and body weight, and blood pressure in fetal and neonatal rats. Journal of Physiology 488, 515–519.Google Scholar
Dallman, MF, Darlington, DN, Suemaru, S, Cascio, CS & Levin, N (1989) Corticosteroids and homeostasis. Acta Physiologica Scandinavica 136, Suppl. S583, 27–34.Google Scholar
Edwards, CRW, Benediktsson, R, Lindsay, RS & Seckl, JR (1993) Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension. Lancet 341, 355–357.Google Scholar
Eilam, R, Malach, R, Bergmann, F & Segal, M (1991) Hypertension induced by hypothalamic transplantation from genetically hypertensive to normotensive rats. Journal of Neuroscience 11, 401–411.Google Scholar
Folkow, B (1978) Cardiovascular structural adaptation: its role in the initiation and maintenance of primary hypertension. Clinical and Scientific Molecular Medicine 55, 3s–22s.Google Scholar
Gardner, DS, Jackson, AA &Langley-Evans, SC (1997) Maintenance of maternal diet-induced hypertension in the rat is dependent upon glucocorticoids. Hypertension 30, 1525–1530.Google Scholar
Godfrey, KM, Forrester, T, Barker, DJP, Jackson, AA, Landman, JP, Hall, JSE, Cox, V & Osmond, C (1994) Maternal nutritional status in pregnancy and blood pressure in childhood. Journal of Obstetrics and Gynaecology 101, 398–403.Google Scholar
Godfrey, KM, Redman, CWG, Barker, DJP & Osmond, C (1991) The effect of maternal anaemia and iron deficiency on the ratio of fetal weight to placental weight. Journal of Obstetrics and Gynaecology 98, 886–891.Google Scholar
Godfrey, KM, Robinson, S, Barker, DJP, Osmond, C & Cox, V (1996) Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. British Medical Journal 312, 410–414.CrossRefGoogle ScholarPubMed
Harding, J, Liu, L, Evans, P, Oliver, M & Gluckman, P (1992) Intrauterine feeding of the growth retarded fetus: Can we help? Early Human Development 29, 193–197.Google Scholar
Isherwood-Peel, SG, Houghton, FD & Leese, H (1998) Effect of a low protein maternal diet on energy metabolism during organogenesis. Proceedings of the Nutrition Society 57, 77A.Google Scholar
Karlberg, J, Jalil, F, Lam, B, Low, L & Yeung, CY (1994) Linear growth retardation in relation to the three phases of growth. European Journal of Clinical Nutrition 48, S25–S44.Google Scholar
Kenyon, CJ & Morton, JJ (1994) Experimental steroid-induced hypertension. In A Textbook of Hypertension, pp. 494–503 [Swales, JD., editor]. Oxford: Blackwell.Google Scholar
Kitraki, E, Alexis, MN, Papalopoulou, M & Stylianopoulou, (1996) Glucocorticoid receptor gene expression in the embryonic rat brain . Neuroendocrinology 63, 305–317.Google Scholar
Langley-Evans, SC & Jackson, AA (1994) Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets. Clinical Science 86, 217–222.Google Scholar
Langley-evans, SC (1997 a) Hypertension induced by fetal exposure to maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis. Journal of Hypertension 15, 537–544.Google Scholar
Langley-Evans, SC (1997 b) Maternal carbenoxolone treatment lowers birth weight and induces hypertension in the offspring of rats fed a protein replete diet. Clinical Science 93, 423–429.Google Scholar
Langley-Evans, SC, Gardner, DS & Jackson, AA (1996 a) Association of disproportionate growth of fetal rats in late gestation with raised systolic blood pressure in later life. Journal of Reproduction and Fertility 106, 307–312.Google Scholar
Langley-Evans, SC, Gardner, DS & Jackson, AA (1996 b) Evidence of programming of the hypothalamic-pituitary-adrenal axis by maternal protein restriction during pregnancy. Journal of Nutrition 126, 1578–1585.Google Scholar
Langley-Evans, SC, Gardner, DS & Jackson, AA (1998) Intrauterine programming of cardiovascular disease by maternal nutritional status. Nutrition 14, 39–47.Google Scholar
Langley-Evans, SC & Jackson, AA (1995) Captopril normalises systolic blood pressure in rats with hypertension induced by fetal exposure to maternal low protein diets. Comparative Biochemistry and Physiology 110, 223–228.CrossRefGoogle ScholarPubMed
Langley-Evans, SC, Phillips, GJ, Gardner, DS & Jackson, AA (1996 c) The role of glucocorticoids in programming of maternal diet induced hypertension in the rat. Journal of Nutritional Biochemistry 7, 173–178.Google Scholar
Langley-Evans, SC, Welham, SJM, Sherman, RC & Jackson, AA (1996 d) Weanling rats exposed to maternal low-protein diets during discrete periods of gestation exhibit differing severity of hypertension. Clinical Science 91, 607–615.Google Scholar
Law, CM, deSwiet, M, Osmond, C, Fayers, PM, Barker, DJP, Cruddas, AM & Fall, CHD (1993) Initiation of hypertension and its amplification throughout life. British Medical Journal 306, 24–27.CrossRefGoogle ScholarPubMed
Law, SC, Barker, DJP, Bull, AR & Osmond, C (1991)Maternal and fetal influences on blood pressure. Archives of Disease in Childhood 66, 1291–1295.Google Scholar
Lever, AF & Harrap, SB (1992) Essential hypertension: A disorder of growth with origins in childhood. Journal of Hypertension 10, 101–120.Google Scholar
Levitt, NS, Lindsay, RS, Holmes, MC & Seckl, JR (1996) Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology 64, 412–418.Google Scholar
Lindsay, RS, Lindsay, M, Edwards, CRW & Secki, JS (1996) Inhibition of 11 β-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring. Hypertension 27, 1200–1204.Google Scholar
Mackenzie, HS & Brenner, BM (1995) Fewer nephrons at birth: A missing link in the etiology of essential hypertension. American Journal of Kidney Disease 26, 91–98.Google Scholar
McEwen, BS, deKloet, ER & Rostene, W (1986) Adrenal steroid receptors and actions in the nervous system. Physiological Reviews 66, 1121–1188.Google Scholar
Meaney, MJ, Aitken, DH,van Berkel, C, Bhathagar, S & Sapolsky, RM (1988) Effect of neonatal handling on age related impairments associated with the hippocampus. Science 329, 766–768.CrossRefGoogle Scholar
Milner, RDG & Gluckman, PD (1996) Regulation of intrauterine growth. In Pediatrics and Perinatology, pp. 285–289 [ Gluckman, PD. and Heymann, MA., editors]. London: Arnold.Google Scholar
Mulay, S, Varma, DR & Solomon, S (1982) Influence of protein deficiency in rats on hormonal status and cytoplasmic glucocorticoid receptors in maternal and fetal tissues. Journal of Endocrinology 95, 49–58.Google Scholar
Petry, CJ, Ozanne, SE, Wang, CL & Hales, CN (1997) Early protein restriction and obesity independently induce hypertension in 1-year old rats. Clinical Science 93, 147–152.Google Scholar
Provencher, PH, Saltis, J & Funder, JW (1995) Glucocorticoids but not mineralocorticoids modulate endothelin-1 and angiotensin II binding in SHR vascular smooth muscle cells. Journal of Steroid Biochemistry and Molecular Biology 52, 219–225.Google Scholar
Rudolph, AM (1984) The fetal circulation and its response to stress. Journal of Developmental Physiology 6, 11–19.Google Scholar
Seckl, JR (1997 a) 11β-Hydroxysteroid dehydrogenase in the brain: A novel regulator of glucocorticoid action. Frontiers in Neuroendocrinology 18, 49–99.Google Scholar
Seckl, JR (1997 b) Glucocorticoids, feto-placental 11 β-hydroxysteroid dehydrogenase type 2, and the early life origins of adult disease. Steroids 62, 89–94.Google Scholar
Sherman, RC, Jackson, AA & Langley-Evans, SC (1997) Early administration of angiotensin converting enzyme inhibitor captopril prevents the development of hypertension programmed by intrauterine exposure to maternal low protein diet in the rat. Clinical Science (In the Press).Google Scholar
Sleight, P, Robinson, JL, Brooks, DE & Rees, PM (1975) Carotid baroreceptor resetting in the hypertensive dog. Clinical Science 48, 261–263.Google Scholar
Stewart, PM, Whorwood, CB & Mason, JI (1995) Type 2 11β-hydroxysteroid dehydrogenase in fetal and adult life. Journal of Steroid Biochemistry and Molecular Biology 55, 465–471.CrossRefGoogle ScholarPubMed
Talman, WT, Granata, AR & Ries, DJ (1984) Glutaminergic mechanisms in the nucleus tractus solitarius in blood pressure control. Federation Proceedings 43, 39–44.Google Scholar
Tangalakis, K, Lumbers, ER, Moritz, KM, Towstoless, MK & Wintour, EM (1992) Effect of cortisol on blood pressure and vascular reactivity in the ovine fetus. Experimental Physiology 77, 709–717.Google Scholar
Thom, TJ, Epstein, FH, Feldman, JJ, Leaverton, PE & Wolz, M (1992) Total Mortality and Mortality from Heart Disease, Cancer and Stroke from 1950 to 1987 in 27 Countries: Highlights of Trends and Their Interrelationships Among Causes of Death. National Institutes of Health Publication. Bethesda, MD: National Institutes of Health.Google Scholar
Walker, BR & Williams, BC (1992) Corticosteroids and vascular tone: mapping the messenger maze. Clinical Science 82, 597– 605.Google Scholar
Walton, A & Hammond, J (1938) The maternal effects on growth and conformation in Shire horse-Shetland pony crosses. Proceedings of the Royal Society of London 125, 311–335.Google Scholar
Ward, R (1990) Hypertension: Pathophysiology, Diagnosis and Management. New York: Raven Press.Google Scholar
Whitworth, JA, Brown, MA, Kelly, JJ & Williamson, PM (1995) Mechanisms of cortisol-induced hypertension in humans. Steroids 60, 76–80.Google Scholar
Wilkinson, R (1994) Renal and renovascular hypertension. In A Textbook of Hypertension, pp. 831–857 [Swales, JD., editor].Oxford: Blackwell.Google Scholar
Woodall, SM, Johnston, BM, Brier, BH & Gluckman, PD (1996) Chronic maternal undernutrition in the rat leads to delayed postnatal growth and elevated blood pressure of offspring. Pediatric Research 40, 438–443.Google Scholar