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Development of antibiotic resistance and options to replace antimicrobials in animal diets

Published online by Cambridge University Press:  05 March 2007

Knud Erik  and
Bach Knudsen
Knud Erik
Affiliation:
Danish Institute of Agricultural Sciences, Department of Animal Nutrition and Physiology, PO Box 50, DK-8830 Tjele, Denmark
Bach Knudsen*
Affiliation:
Danish Institute of Agricultural Sciences, Department of Animal Nutrition and Physiology, PO Box 50, DK-8830 Tjele, Denmark
*
Corresponding author: Dr Knud Erik Bach Knudsen, fax +45 89 99 13 78, email [email protected]
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Abstract

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As there is a risk of developing antibiotic resistance, a number of commonly-used antimicrobial growth promoters have been banned in the EU member states. This decision has put new emphasis on using the diet to control enteric bacterial infections of pigs. Dietary carbohydrates constitute a major proportion of diets for pigs, and the carbohydrate fraction has a diverse composition, with different properties in the gastrointestinal tract, some of which are of importance to gut health. Findings from different studies indicate that dietary carbohydrate composition influences the expression of swine dysentery and infection with nematode worms after experimental challenge with Brachyspira hyodesenteriae and Oesophagostumum dentatum respectively. In both cases the type, amount and physico-chemical properties of the carbohydrates entering the large intestine played an important role in the infection, and emerging data suggest a synergism between different porcine pathogens. There is also increasing evidence that the feed structure, which relates to the type of plant material in the diet and the way it is processed, can be used to reduce Salmonella prevalence at the herd level. However, it should be stressed that using the diet to manage gut health is not straightforward, since the expression of a pathogen in many cases requires the presence of other components of the commensal biota.

Keywords

PigsAntibiotic resistanceCarbohydratesBacteriaParasites
Type
Animal Nutrition and Metabolism Group Symposium on ‘Quality inputs for quality foods’
Information
Proceedings of the Nutrition Society , Volume 60 , Issue 3 , August 2001 , pp. 291 - 299
Copyright
Copyright © The Nutrition Society 2001

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