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Defects in substrate oxidation involved in the predisposition to obesity

Published online by Cambridge University Press:  28 February 2007

Arne Astrup ,
Benjamin Buemann ,
SøRen Toubro  and
Anne Raben
Arne Astrup
Affiliation:
Research Department of Human Nutrition and KVL Centre for Food Research, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Copenhagen, Denmark
Benjamin Buemann
Affiliation:
Research Department of Human Nutrition and KVL Centre for Food Research, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Copenhagen, Denmark
SøRen Toubro
Affiliation:
Research Department of Human Nutrition and KVL Centre for Food Research, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Copenhagen, Denmark
Anne Raben
Affiliation:
Research Department of Human Nutrition and KVL Centre for Food Research, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Copenhagen, Denmark
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Abstract

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Type
Symposium 2
Information
Proceedings of the Nutrition Society , Volume 55 , Issue 3 , November 1996 , pp. 817 - 828
Copyright
Copyright © The Nutrition Society 1996

References

Astrup, A., Buemann, B., Christensen, N. J. & Madsen, J. (1992). 24-h energy expenditure and sympathetic activity in postobese women consuming a high-carbohydrate diet. American Journal of Physiology 262, E282–E288.Google ScholarPubMed
Astrup, A., Buemann, B., Christensen, N. J. & Toubro, S. (1994 a). Failure to increase lipid oxidation in response to increasing dietary fat content in formerly obese women. American Journal of Physiology 266, E592–E599.Google ScholarPubMed
Astrup, A., Buemann, B., Toubro, S., Ranneries, C. & Raben, A. (1996). Low resting metabolic rate in subjects predisposed to obesity: a role for thyroid status. American Journal of Clinical Nutrition 63, 879–883.CrossRefGoogle ScholarPubMed
Astrup, A., Buemann, B., Western, P., Toubro, S., Raben, A. & Christensen, N. J. (1994 b). Obesity as an adaptation to a high-fat diet: evidence from a cross-sectional study. American Journal of Clinical Nutrition 59, 350–355.CrossRefGoogle ScholarPubMed
Astrup, A. & Flatt, J. P. (1996). Metabolic determinants of body weight regulation. In Regulation of Body Weight. Biological and Behavioral Mechanisms, pp. 193–210 [Bouchard, C. and Bray, G. A., editors]. Chichester: John Wiley &Sons Ltd.Google Scholar
Astrup, A. & Raben, A. (1996 a). Glucostatic control of intake and obesity. Proceedings of the Nutrition Society 55, 417–427.CrossRefGoogle ScholarPubMed
Astrup, A. & Raben, A. (1996 b). Mono- and disaccharides: Nutritional aspects. In Carbohydrates in Food, pp. 159–189 [Eliasson, A.-C., editor]. New York: Marcel Dekker Inc.Google Scholar
Astrup, A., Sørensen, C., Bülow, J., Buemann, B., Madsen, J. & Christensen, N. J. (1994c). Fat mobilization and utilization during rest and exercise in postobese women. International Journal of Obesity 18, Suppl. 2, 23 Abstr.Google Scholar
Bouchard, C. & Bray, G. A. (1996). Introduction. In Regulation of Body Weight. Biological and Behavioral Mechanisms, pp. 1–13 [Bouchard, C. and Bray, G. A., editors]. Chichester: John Wiley & Sons Ltd.Google Scholar
Bouchard, C., Dériaz, O., Pérusse, L. & Tremblay, A. (1994). Genetics of energy expenditure in humans. In The Genetics of Obesity, pp. 135–145 [Bouchard, C., editor]. London and Tokyo: CRC Press.Google Scholar
Bouchard, C., Tremblay, A., Després, J. P., Nadeau, A., Lupien, P. J., Thériault, G., Dussault, J., Moorjani, S., Pinault, S. & Fournier, G. (1990). The response to long-term overfeeding in identical twins. New England Journal of Medicine 322, 1477–1482.CrossRefGoogle ScholarPubMed
Bouchard, C., Tremblay, A., Nadeau, A., Després, J. P., Thériault, G., Boulay, M. R., Lortie, G., Leblanc, C. & Fournier, G. (1989). Genetic effect in resting and exercise metabolic rates. Metabolism 38, 364–370.CrossRefGoogle ScholarPubMed
Buemann, B., Toubro, S.,Raben, A. & Astrup, A. (1994). Substrate oxidations in postobese women on 72-h high fat diet. A possible abnormal postprandial response? International Journal of Obesity 18, Suppl. 2, 97 Abstr.Google Scholar
Considine, R. V., Sinha, M. K., Heiman, M. L., Kríaucinas, A., Stephens, T. W., Nyce, M. R., Channesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L. & Caro, J. F. (1996). Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 334, 292–295:CrossRefGoogle ScholarPubMed
Dériaz, O., Dionne, F., Pérusse, L., Tremblay, A., Vohol, M. C., Côte, G. & Bouchard, C. (1994). DNA variation in the genes of the Na, K-adenosine triphosphatase and its relation with resting metabolic rate, respiratory quotient, and body fat. Journal of Clinical Investigation 93, 838–843.CrossRefGoogle ScholarPubMed
Drewnowski, A., Brunzell, J. D., Sande, K., Iverius, P. H. & Greenwood, M. R. C. (1985). Sweet tooth reconsidered: taste responsiveness in human obesity. Physiology and Behavior 35, 617–622.CrossRefGoogle ScholarPubMed
Drewnowski, A., Kurth, C. L. & Rahaim, J. E. (1991). Taste preferences in human obesity: environmental and familial factors. American Journal of Clinical Nutrition 54, 635–641.CrossRefGoogle ScholarPubMed
Dyck, D. J., Putman, C. T., Heighenhauser, G. J. F., Hultman, E. & Spriet, L. L. (1993). Regulation of fat-carbohydrate interaction in skeletal muscle during intense aerobic cycling. American Journal of Physiology 265, E852–E859.Google ScholarPubMed
Eckel, R. H., Ailhaud, G., Astmp, A., Flatt, J. P., Hauner, H., Levine, A. S., Prentice, A. M., Ricquier, D., Steffens, A. B. & Woods, S. C. (1996). Group report. What are the metabolic and physiological mechanisms associated with the regulation of body weight? In Regulation of Body Weight: Biological and Behavioral Mechanisms, pp. 222–238 [Bouchard, C. and Bray, G. A., editors]. Chichester: John Wiley & Sons Ltd.Google Scholar
Ferraro, R. T., Eckel, R. H., Larson, D. E., Fontvieille, A. M., Rising, R., Jensen, D. R. & Ravussin, E. (1993). Relationship between skeletal muscle lipoprotein lipase activity and 24-hour macronutrient oxidation. Journal of Clinical Investigation 92, 441–445.CrossRefGoogle ScholarPubMed
Flatt, J. P. (1987). Dietary fat, carbohydrate balance, and weight maintenance: effects of exercise. American Journal of Clinical Nutrition 45, 296–306.CrossRefGoogle ScholarPubMed
Hansen, H., Raben, A. & Astrup, A. (1995). The habitual diet of post-obese is lower in fat and higher in carbohydrate compared to matched controls. International Journal of Obesity 19, 82 Abstr.Google Scholar
Heitmann, B. L., Lissner, L., Sørensen, T. I. A. & Bengtsson, C. (1995). Dietary fat intake and weight gain in women genetically predisposed for obesity. American Journal of Clinical Nutrition 61, 1213–1217.CrossRefGoogle ScholarPubMed
Klausen, B., Toubro, S. & Astrup, A. (1996). High-intensity exercise stimulates the subsequent day's fat intake. International Journal of Obesity 20, Suppl. 4, 67 Abstr.Google Scholar
Lean, M. E. J. & James, W. P. T. (1988). Metabolic effects of isoenergetic nutrient exchange over 24 hours in relation to obesity in women. International Journal of Obesity 12, 15–27.Google ScholarPubMed
Lillioja, S., Young, A. A., Culter, C. L., Ivy, J. L., Abbott, W. G., Zawadski, J. K., Yki-Jarvinen, H., Christin, L., Secomb, T. W. & Bogardus, C. (1987). Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. Journal of Clinical Investigation 80, 415–424.CrossRefGoogle ScholarPubMed
Prentice, A. M. (1995). Alcohol and obesity. International Journal of Obesity 19, Suppl., 544–550.Google ScholarPubMed
Raben, A., Andersen, H. B., Christensen, N. J., Madsen, J., Holst, J. J. & Astrup, A. (1994). Evidence for an abnormal postprandial response to a high-fat meal in women predisposed to obesity. American Journal of Physiology 267, E549–ES59.Google ScholarPubMed
Raben, A., Toubro, S. & Astrup, A. (1996). Improved insulin sensitivity after 14-d ad libitum sucrose-rich diet compared with a fat-rich or starch-rich diet. International Journal of Obesity 20, Suppl. 4, 67 Abstr.Google Scholar
Randle, P. J., Garland, P. B., Hales, C. N. & Newsholme, E. A. (1963). The glucose fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1, 785–789.CrossRefGoogle ScholarPubMed
Ravussin, E. (1995). Metabolic differences and the development of obesity. Metabolism 9, Suppl. 3, 12–14.CrossRefGoogle Scholar
Rolls, B. J., Kim-Harris, S., Fischman, M. W., Foltin, R. W., Moran, T. H. & Stoner, S. A. (1994). Satiety after preloads with different amounts of fat and carbohydrate: implications for obesity. American Journal of Clinical Nutrition 60, 476–487.CrossRefGoogle ScholarPubMed
Seidell, J. C., Muller, D. C., Sorkin, J. D. & Andres, R. (1992). Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging. International Journal of Obesity 16, 667–474.Google ScholarPubMed
Simoneau, J.-A. & Bouchard, C. (1995). Skeletal muscle metabolism and body fat content in men and women. Obesity Research 3, 23–29.Google ScholarPubMed
Simoneau, J.-A., Tremblay, A., Thériault, G. & Bouchard, C. (1994). Relationships between the metabolic protile of skeletal muscle and body fat gain in response to overfeeding. Medicine and Science in Sports and Exercise 5, S159.CrossRefGoogle Scholar
Spraul, M., Ravussin, E., Fontvieille, A. M., Rising, R., Larson, D. E. & Anderson, E. A. (1993). Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. Journal of Clinical Investigation 92, 1730–1735.CrossRefGoogle ScholarPubMed
Swinburn, B., Nyomba, B. L., Saad, M. F., Zurlo, F. & Raz, I. (1991). Insulin resistance associated with lower rates of weight gain in Pima Indians. Journal of Clinical Investigation 88, 168–173.CrossRefGoogle ScholarPubMed
Toubro, S., Christensen, N. J. & Astrup, A. (1995). Reproducibility of 24-h energy expenditure, substrate utilization and spontaneous physical activity in obesity measured in a respiration chamber. International Journal of Obesity 19, 544–549.Google Scholar
Toubro, S., Sørensen, T. I. A., Rønn, B., Christensen, N. J. & Astrup, A. (1996). 24-h energy expenditure: the role of body composition, thyroid status, sympathetic activity and family membership. Journal of Endocrinology and Metabolism (In the Press).Google ScholarPubMed
Toubro, S., Western, P., Bülow, J., Macdonald, I., Raben, A., Christensen, N. J., Madsen, J. & Astrup, A. (1994). Insulin sensitivity in post-obese women. Clinical Science 84, 407–413.CrossRefGoogle Scholar
Tremblay, A. (1995). Differences in fat balance underlying obesity. International Journal of Obesity 19, S10–S14.Google ScholarPubMed
Verboeket-van de Venne, W. P. H. G., Westerterp, K. R. & ten Hoor, F. (1994). Substrate utilization in man: effects of dietary fat and carbohydrate. Metabolism 43, 152–156.CrossRefGoogle ScholarPubMed
Wade, A. J., Marbut, M. M. & Round, J. M. (1990). Muscle fibre type and aetiology of obesity. Lancet 335, 805–808.CrossRefGoogle ScholarPubMed
Weigle, D. S., Bukowski, T. R., Foster, D. C., Holderman, S., Kramer, J. M., Lasser, G., Lofton-Day, C. E., Prunkard, D. E., Raymond, C. & Kuijper, J. L. (1995). Recombinant ob protein reduces feeding and body weight in ob/ob mouse. Journal of Clinical Investigation 96, 2065–2070.CrossRefGoogle ScholarPubMed
Zurlo, F., Lillioja, S., Esposito-Del Puente, A., Nyomba, B. L., Raz, I., Saad, M. F., Swinbum, B. A., Knowler, W. C., Bogardus, C. & Ravussin, E. (1990). Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. American Journal of Physiology 259, E650–E657.Google ScholarPubMed
Zurlo, F., Nemeth, P. M., Choksi, R. M., Sesodia, S. & Ravussin, E. (1994). Whole-body energy metabolism and skeletal muscle biochemical characteristics. Metabolism 43, 481–486.CrossRefGoogle ScholarPubMed