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Can resistant starch and/or aspirin prevent the development of coloi neoplasia? The Concerted Action Polyp Prevention (CAPP) 1 Study

Published online by Cambridge University Press:  05 March 2007

John C. Mathers ,
Ian Mickleburgh ,
Pam C. Chapman ,
D. Tim Bishop  and
John Burn
John C. Mathers*
Affiliation:
Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
Ian Mickleburgh
Affiliation:
Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
Pam C. Chapman
Affiliation:
Institute of Human Genetics, University of Newcastle, Bioscience Centre, Times Square, Scotswood Road, Newcastle upon Tyne, NE1 4EP, UK
D. Tim Bishop
Affiliation:
Genetic Epidemiology Division, Cancer Research UK, University of Leeds, Cancer Genetics Building, St James's University Hospital, Leeds LS9 7TF, UK
John Burn
Affiliation:
Institute of Human Genetics, University of Newcastle, Bioscience Centre, Times Square, Scotswood Road, Newcastle upon Tyne, NE1 4EP, UK
*
*Corresponding author: Professor John Mathers, fax +44 191 222 8684, [email protected]
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Abstract

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Loss of function of the adenomatous polyposis coli (APC) tumour suppressor gene through truncating mutations or other means is an early event in most colo-rectal cancer (CRC). The AFC gene encodes a large multifunctional protein that plays key roles in several cellular processes, including the wnt signalling pathway where an intact APC protein is essential for down regulation of β-catenin. The APC protein also plays a role in regulation of cell proliferation, differentiation, apoptosis, cell-cell adhesion, cell migration and chromosomal stability during mitosis. Acquisition of a non-functional APC gene can occur by inheritance (in the disease familial adenomatous polyposis (FAP)) or by a sporadic event in a somatic cell. Whilst there is strong epidemiological evidence that variation in diet is a major determinant of variation in CRC incidence, conventional adenoma recurrence trials in sporadic cases of the disease have been relatively unsuccessful in identifying potentially protective food components. Since the genetic basis of CRC in FAP and in sporadic CRC is similar, intervention trials in FAP gene carriers provide an attractive strategy for investigation of potential chemo-preventive agents, since smaller numbers of subjects and shorter time frames are needed. The Concerted Action Polyp Prevention (CAPP) 1 Study is using a 2×2 factorial design to test the efficacy of resistant starch (30 g raw potato starch-Hylon VII (1:1, w/w)/d) and aspirin (600 mg/d) in suppressing colo-rectal adenoma formation in young subjects with FAP. Biopsies of macroscopically-normal rectal mucosa are also being collected for assay of putative biomarkers of CRC risk.

Keywords

Adenomatous polyposis coliColo-rectal cancerFamilial adenomatous polyposisresistant starchAsprin
Type
Session: Whole cereal grains, fibre and human cancer
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 1 , February 2003 , pp. 51 - 57
Copyright
Copyright © The Nutrition Society 2003

References

Asano, T & McLeod, RS (2002) Dietary fibre for the prevention of colorectal adenomas and carcinomas (Cochrane Review). Cochrane Database Systematic Reviews CD003430. Oxford: The Cochrane Library.Google Scholar
Baeg, GH, Matsumine, A, Kuroda, T, Bhattacharjee, RN, Miyashiro, I, Toyoshima, K & Akiyama, T (1995) The tumor-suppressor gene product APC blocks cell-cycle progression from G0/G1 to S-phase. EMBO Journal 14, 5618–5625.CrossRefGoogle ScholarPubMed
Barnes, CJ & Lee, M (1998) Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin. Gastroenterology 114, 873–877.CrossRefGoogle ScholarPubMed
Beazer-Barclay, Y, Levy, DB, Moser, AR, Dove, WF, Hamilton, SR, Vogelstein, B & Kinzler, KW (1996) Sulindac suppresses tumorigenesis in the Min mouse. Carcinogenesis 17, 1757–1760.CrossRefGoogle ScholarPubMed
Bedi, A, Pasricha, PJ, Akhtar, AJ, Barber, JP, Bedi, GC, Giardello, FM, Zehnbauer, BA, Hamilton, SR & Jones, RJ (1995) Inhibition of apoptosis during development of colorectal-cancer. Cancer Research 55, 1811–1816.Google ScholarPubMed
Behrens, J, Vonkries, JP, Kuhl, M, Bruhn, L, Wedlich, D, Grosschedl, R & Birchmeir, W (1996) Functional interaction of β-catenin with the transcription factor Lef–1. Nature 382, 638–642.CrossRefGoogle ScholarPubMed
Bienz, M (2002) The subcellular destinations of APC proteins. Nature Reviews Molecular Cell Biology 3, 328–338.CrossRefGoogle ScholarPubMed
Burn, J, Chapman, PD, Bishop, DT & Mathers, J (1998) Diet and cancer prevention: the Concerted Action Polyp Prevention (CAPP) Studies. Proceedings of the Nutrition Society 57, 183–186.CrossRefGoogle ScholarPubMed
Burn, J, Chapman, PD, Bishop, DT, Smalley, S, Mickleburgh, I, West, S & Mathers, JC (2001) Susceptibility markers in colorectal cancer Biomarkers in Cancer. In Biomarkers in Cancer Chemoprevention, pp.131–147 [Miller, AB, Bartsch, H, Boffetta, P, Dragsted, L, Vanio, H, editors] Lyon, France: International Agency for Research on Cancer.Google Scholar
Chai, F, Evdokiou, A, Young, GP & Zalewski, PD (2000) Involvement of p21 (Waf1/Cip1) and its cleavage by DEVDcaspase during apoptosis of colorectal cancer cells induced by butyrate. Carcinogenesis 21, 7–14.CrossRefGoogle ScholarPubMed
Debinski, HS, Trojan, J, Nugent, KP, Spigelman, AD & Phillips, RK (1995) Effect of sulindac on small polyps in familial adenomatous polyposis. Lancet 345, 855–856.CrossRefGoogle ScholarPubMed
Department of Health (1998) Nutritional Aspects of the Development of Cancer. Report on Health and Social Subjects, no. 48 London: The Stationery Office.Google Scholar
Elder, DJE & Paraskeva, C (1997) NSAIDs to prevent colorectal cancer: A question of sensitivity. Gastroenterology 113, 1999–2008.Google ScholarPubMed
Esteller, M, Sparks, A, Toyota, M, Sanchez-Cespedes, M, Capella, G, Peinado, MA, Gonzalez, S, Tarafa, G, Sidransky, D, Meltzer, SJ, Baylin, SB & Herman, JG (2000) Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Research 60, 4366–4371.Google ScholarPubMed
Fearnhead, NS, Britton, MP & Bodmer, WF (2001) The ABC of APC. Human Molecular Genetics 10, 721–733.CrossRefGoogle ScholarPubMed
Fodde, R, Kuipers, J, Rosenberg, C, Smits, R, Kielman, M, Gaspar, C, van Es, JH, Bruekel, C, Weigant, J, Giles, RH & Cleavers, H (2001a) Mutations of the APC tumour suppressor gene cause chromosomal instability. Nature Cell Biology 3, 433–438.CrossRefGoogle ScholarPubMed
Fodde, R, Smits, R & Clevers, H (2001b) APC, signal transduction and genetic instability in colorectal cancer. Nature Reviews Cancer 1, 55–67.CrossRefGoogle ScholarPubMed
Fodde, R, Smits, R, Hofland, N, Kielman, M, Meera Khan, P (1999) Mechanisms of APC-driven tumorigenesis. Cytogenetics and Cell Genetics 86, 105–111.CrossRefGoogle ScholarPubMed
Giardiello, FM (1994) Sulindac and polyp regression. Cancer Metastasis Review 13, 279–283.CrossRefGoogle ScholarPubMed
Groden, J, Joslyn, G, Samowitz, W, Jones, D, Bhattacharyya, N, Spirio, L, Thliveris, A, Robertson, M, Egan, S, Meuth, M & White, R (1995) Response of colon-cancer cell-lines to the introduction of APC a colon-specific tumor-suppressor gene. Cancer Research 55, 1531–1539.Google Scholar
Groden, J, Thliveris, A, Samowitz, W, Carlson, M, Gelbert, L, Albertsen, H, Joslyn, G, Stevens, J, Spirio, L, Robertson, M, Sarheant, L, Krapcho, K, Wolff, E, Burt, R, Hughes, JP, Warrington, J, McPherson, J, Wasmuth, J, Lepaslier, D, Abderrahim, H, Cohen, D, Leppert, M & White, R (1991) Identification and characterisation of the familial adenomatous polyposis-coli gene. Cell 66, 589–600.CrossRefGoogle ScholarPubMed
Hague, A, Manning, AM, Hanlon, KA, Huschtscha, LI, Hart, D & Paraskeva, C (1993) Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. International Journal of Cancer 55, 498–505.CrossRefGoogle Scholar
Hanahan, D & Weinberg, RA (2000) The hallmarks of cancer. Cell 100, 57–70.CrossRefGoogle ScholarPubMed
He, TC, Sparks, AB, Rago, C, Hermeking, H, Zawel, L, da Costa, LT, Morin, PJ, Vogelstein, B and Kinzler, KW (1998) Identification of c-MYC as a target of the APC pathway. Science 281, 1438–1441.CrossRefGoogle ScholarPubMed
Henderson, BR (2000) Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localisation and turnover. Nature Cell Biology 2, 653–660.CrossRefGoogle ScholarPubMed
Horii, A, Nakatsuru, S, Ichii, S, Nagase, H & Nakamura, Y (1993) Multiple forms of the Apc gene transcripts and their tissue-specific expression. Human Molecular Genetics 2, 283–287.CrossRefGoogle ScholarPubMed
Kennedy, AR, Beazer-Barclay, Y, Kinzler, KW & Newberne, PM (1996) Suppression of carcinogenesis in the intestines of Min mice by soybean-derived Bowman-Birk inhibitor. Cancer Research 56, 679–682.Google ScholarPubMed
Kinzler, KW, Nilbert, MC, Su, LK, Vogelstein, B, Bryan, TM, Levy, DB, Smith, KJ, Preisinger, AC, Hedge, P, McKechnie, D, Finniear, R, Markham, A, Groffen, J, Boguski, MS, Altshul, SF, Horii, A, Ando, H, Miyoshi, Y, Miki, Y, Nishisho, I & Nakamura, Y (1991) Identification of FAP locus genes from chromosome 5q21. Science 253, 661–665.CrossRefGoogle ScholarPubMed
Kishida, S, Yamamoto, H, Ikeda, S, Kishida, M, Sakamoto, I, Koyama, S & Kikuchi, A (1998) Communication–Axin, a negative regulator of the Wnt signalling pathway, directly interacts with adenomatous polyposis coli and regulates stabilization of β-catenin. Journal of Biological Chemistry 273, 10823–10826.CrossRefGoogle ScholarPubMed
Klingensmith, J & Nusse, R (1994) Signalling by Wingless in Drosophila. Developmental Biology 166, 396–414.CrossRefGoogle ScholarPubMed
Levy, DB, Smith, KJ, Beazer-Barclay, Y, Hamilton, SR, Vogelstein, B & Kinzler, KW (1994) Inactivation of both APC alleles in human and mouse tumors. Cancer Research 54, 5953–5958.Google ScholarPubMed
MacGregor, D, Kim, YS, Sleisenger, MH & Johnson, LK (2000) Chemoprevention of colon cancer carcinogenesis by balsalazide: Inhibition of azoxymethane-induced aberrant crypt formation in the rat colon and intestinal tumor formation in the B6-Min/ +mouse. International Journal of Oncology 17, 173–179.Google ScholarPubMed
Mathers, JC, Smith, H & Carter, S (1997) Dose-response effects of raw potato starch on small-intestinal escape, large bowel fermentation and gut transit time in the rat. British Journal of Nutrition 78, 1015–1029.CrossRefGoogle ScholarPubMed
Midgley, CA, White, S, Howitt, R, Save, V, Dunlop, MG, Hall, PA, Lane, DP, Wyllie, AH & Bubb, VJ (1997) APC expression in normal human tissues. Journal of Pathology 181, 426–433.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Morin, PJ, Vogelstein, B & Kinzler, KW (1996) Apoptosis and APC in colorectal tumorigenesis. Proceedings of the National Academy of Sciences USA 93, 7950–7954.CrossRefGoogle ScholarPubMed
Nakagawa, H, Murata, Y, Koyama, K, Fujiyama, A, Miyoshi, Y, Monden, M, Akiyama, T & Nakamura, Y (1998) Identification of a brain-specific APC homologue, APCL, and its interaction with β-catenin. Cancer Research 58, 5176–5181.Google ScholarPubMed
Neufeld, KL, Zhang, F, Cullen, BR & White, RL (2000) APCmediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export. EMBO Reports 1, 519–523.CrossRefGoogle ScholarPubMed
Newman, JV, Kosaka, T, Sheppard, BJ, Fox, JG & Schauer, DB (2001) Bacterial infection promotes colon tumorigenesis in ApcMin +mice. Journal of Infectious Diseases 184, 227–230.CrossRefGoogle Scholar
Phillips, RK, Wallace, MH, Lynch, PM, Hawk, E, Gordon, GB, Saunders, BP, Wakabayaski, N, Shen, Y, Zimmerman, S, Godio, L, Rodrigues-Bigas, M, Su, LK, Sherman, J, Kelloff, G, Levin, B, Steinbach, G & Steinbach, G (2002) A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase inhibitor, on duodenal polyposis in familial adenomatous polyposis. Gut 50, 857–860 FAP Study GroupCrossRefGoogle ScholarPubMed
Powell, SM, Zilz, N, Beazer-Barclay, Y, Bryan, TM, Hamilton, SR, Thibodeau, SN, Vogelstein, B & Kinzler, KW (1992) Apc mutations occur early during colorectal tumorigenesis. Nature 359, 235–237.CrossRefGoogle ScholarPubMed
Pyles, RB, Santoro, IM, Groden, J & Parysek, LM (1998) Novel protein isoforms of the APC tumour suppressor in neural tissue. Oncogene 16, 77–82.CrossRefGoogle ScholarPubMed
Rehberg, M & Graf, R (2002) Dictyostelium EB1 is a genuine centrosomal component required for proper spindle formation. Molecular Biology of the Cell 13, 2301–2310.CrossRefGoogle ScholarPubMed
Rockman, SP, Currie, SA, Ciavarella, M, Vincan, E, Dow, C, Thomas, RJ & Phillips, WA (2001) Id2 is a target of the betacatenin/ T cell factor pathway in colon carcinoma. Journal of Biological Chemistry 276, 45113–45119.CrossRefGoogle ScholarPubMed
Rubinfeld, B, Albert, I, Porfiri, E, Munemitsu, S & Polakis, P (1997) Loss of β-catenin regulation by the APC tumor suppressor protein correlates with the loss of structure due to common somatic mutations of the gene. Cancer Research 57, 4624–4630.Google ScholarPubMed
Santoro, IM & Groden, J (1997) Alternative splicing of the APC gene and its association with terminal differentiation. Cancer Research 57, 488–494.Google ScholarPubMed
Schatzkin, A, Lanza, E, Corle, D, Lance, P, Shike, M, Weissfeld, J, Burt, R, Cooper, MR, Kikendall, JW & Cahill, J (2000) Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. New England Journal of Medicine 342, 1149–1155.CrossRefGoogle ScholarPubMed
Steinbach, G, Lynch, PM, Phillips, RK, Wallace, MH, Hawk, E, Gordon, GB, Wakabayashi, N, Saunders, B, Shen, Y, Fujimura, T, Su, LK & Levin, B (2000) The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. New England Journal of Medicine 342, 1946–1952.CrossRefGoogle ScholarPubMed
Strachan, T &, Read, (1999) Human Molecular Genetics 2, 435–436. Oxford: BIOS Scientific Publishers Ltd.Google Scholar
Su, LK, Vogelstein, B & Kinzler, KW (1993) Association of the Apc tumor-suppressor with catenins. Science 262, 1734–1737.CrossRefGoogle ScholarPubMed
Sulekova, Z & Ballhausen, WG (1995) A novel coding exon of the human adenomatous polyposis-coli gene. Human Genetics 96, 469–471.CrossRefGoogle ScholarPubMed
Sunayama, K, Konno, H, Kakamura, T, Kashiwabara, H, Shoji, T, Tsuneyoshi, T & Nakamura, S (2002) The role of cyclooxygenase- 2 (COX-2) in two different morphological stages of intestinal polyps in APCΔ474 knockout mice. Carcinogenesis 23, 1351–1359.CrossRefGoogle ScholarPubMed
Thliveris, A, Albertsen, H, Tuohy, T, Carlson, M, Groden, J, Joslyn, G, Gelbert, L, Samowitz, W, Spirio, L & White, R (1996) Long-range physical map and deletion characterization of the 1100-kb Not1 restriction fragment harboring the APC gene. Genomics 34, 268–270.CrossRefGoogle Scholar
Trzepacz, C, Lowy, AM, Kordich, JJ & Groden, J (1997) Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34 (cdc2). Journal of Biological Chemistry 272, 21681–21684.CrossRefGoogle ScholarPubMed
Wasan, H, Novelli, M, Bee, J & Bodmer, WF (1997) Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proceedings of the National Academy of Sciences USA 94, 3308–3313.CrossRefGoogle ScholarPubMed
Williamson, SLH, Kartheuser, A, Coaker, J, Kooshkghazi, MD, Fodde, R, Burn, J & Mathers, JC (1999) Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months. Carcinogenesis 20, 805–810.CrossRefGoogle ScholarPubMed
Yamada, T, Takaoka, AS, Naishiro, Y, Hayashi, R, Maruyama, K, Maesawa, C, Ochiai, A & Hirohashi, S (2000) Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis. Cancer Research 60, 4761–4766.Google ScholarPubMed
Zhang, F, White, RL & Neufeld, KL (2000) Phosphorylation near nuclear localisation signal regulates nuclear import of adenomatous polyposis coli protein. Proceedings of the National Academy of Sciences USA 97, 12577–12582.CrossRefGoogle ScholarPubMed