Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-20T06:42:06.607Z Has data issue: false hasContentIssue false
  • English
  • Français

Are milk polyamines preventive agents against food allergy?

Published online by Cambridge University Press:  28 February 2007

Guy Dandrifosse ,
O. Peulen ,
N. El Khefif ,
P. Deloyer ,
A. C. Dandrifosse  and
Ch. Grandfils
Guy Dandrifosse*
Affiliation:
Department of Biochemistry and Physiology, Institute of Chemistry, University of Liege, Sart Tilman 4000, Liege, Belgium
O. Peulen
Affiliation:
Department of Biochemistry and Physiology, Institute of Chemistry, University of Liege, Sart Tilman 4000, Liege, Belgium
N. El Khefif
Affiliation:
Department of Biochemistry and Physiology, Institute of Chemistry, University of Liege, Sart Tilman 4000, Liege, Belgium
P. Deloyer
Affiliation:
Department of Biochemistry and Physiology, Institute of Chemistry, University of Liege, Sart Tilman 4000, Liege, Belgium
Ch. Grandfils
Affiliation:
Department of Biochemistry and Physiology, Institute of Chemistry, University of Liege, Sart Tilman 4000, Liege, Belgium
*
*Corresponding author: Professor Guy Dandrifosse, fax +32 43 66 28 87, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Insufficient polyamine intake could play a role in the induction of sensitization to dietary allergens. This proposal is based essentially on investigations made in sucking rats and in children. In sucking rats it has been established that oral administration of spermine can induce all the modifications occurring in the digestive tract at weaning. In the intestine events occur in two phases. The early event consists of desquamation of the epithelium resulting from an activation of apoptosis. The late event appears to involve an hormonal cascade in which adrenocorticotropic hormone, cytokines, bombesin and corticosterone are included. Observations in human subjects show that: (1) the spermine and spermidine concentrations are generally lower in infant formulas than in human breast milk. Mothers seem consistently to have relatively high or relatively low concentrations of spermine and spermidine in their milk. These individual variations may be due to diet, lifestyle or genetic background; (2) the probability of developing allergy can reach 80 % if the mean spermine concentration in the milk is lower than 2 nmol/ml milk. It is approximately 0 % if the mean spermine concentration is higher than 13 nmol/ml milk; (3) preliminary results show that the intestinal permeability to macromolecules differs in premature babies when they are fed on breast milk compared with infant formulas (J Senterre, J Rigo, G Forget, G Dandrifosse and N Romain, unpublished results). This difference does not seem to be present when powdered milk is supplemented with polyamines at the concentration found in breast milk; (4) spermine increases proliferation and differentiation of lymphocytes isolated from the tonsils of children.

Keywords

PolyamineMilkAllergyPreventive medicine
Type
Micronutrient Group Symposium on ‘The role of micronutrients as modulators of development’
Information
Proceedings of the Nutrition Society , Volume 59 , Issue 1 , February 2000 , pp. 81 - 86
Copyright
Copyright © The Nutrition Society 2000

References

Andre, F, Andre, C, Feknous, M, Colin, L & Cavagna, S (1991) Digestive permeability to different-sized molecules and to sodium cromoglycate in food allergy. Allergy Proceedings 12, 293–298.CrossRefGoogle ScholarPubMed
Axelsson, I, Jakobsson, I, Lindberg, T, Polberger, S, Benediktsson, B & Räihä, N (1989) Macromolecular absorption in preterm and term infants. Acta Paediatrica Scandinavica 78, 532–537.CrossRefGoogle ScholarPubMed
Bender, AE & Matthews, DR (1981) Adverse reactions to foods. British Journal of Nutrition 46, 403–407.CrossRefGoogle ScholarPubMed
Buts, JP, De Keyser, N, De Raedemaeker, L, Collette, E & Sokal, EM (1995) Polyamine profiles in human milk, infant formulas, and semi-elemental diets. Journal of Pediatric Gastroenterology and Nutrition 21, 44–49.Google ScholarPubMed
Buts, JP, De Keyser, N, Kolanowski, J, Sokal, E & Van, Hoof F (1993) Maturation of villus and crypt cell functions in rat small intestine. Role of dietary polyamines. Digestive Diseases and Sciences 38, 1091–1098.CrossRefGoogle ScholarPubMed
Buts, J-P, De Keyser, N, Romain, N, Dandrifosse, G, Sokal, E & Nsengiyumva, T (1994) Response of rat immature enterocytes to insulin: regulation by receptor binding and uptake of endoluminal polyamine uptake. Gastroenterology 106, 49–59.CrossRefGoogle ScholarPubMed
Coombes, RRA & Gell, PGH (1963) The classification of allergic reactions underlying disease. In Clinical Aspects of Immunology, pp. 313–317 [Gell, PGH and Coombes, RRA, editors]. Oxford: Blackwell Science.Google Scholar
Dandrifosse, G, Deloyer, P, El, Khefif N & Peulen, O (1999) Dietary polyamines during lactation. In Polyamines in Health and Nutrition, pp. 213–231 [Bardocz, S and White, A, editors]. Boston: Kluwer Academic Publishers.Google Scholar
Dandrifosse, G, Forget, G, Romain, N, Deloyer, P & Wery, I (1991) Maturation précoce de l'intestin du rat par la spermine: résultats et perspectives (Early maturation of rat intestine by spermine: results and prospects). In Les Polyamines: Chimie, Biologie, Médecine (Polyamines: Chemistry, Biology, Medicine), pp. 237–247 [Moulinoux, JP and Quemener, V, editors]. Paris: Flammarion.Google Scholar
Deloyer, P, Dandrifosse, G, Bartholomeus, C, Romain, N, Klimek, M, Salmon, J, Gérard, P, Goessens, G & Eyssen, H (1996) Polyamine and intestinal properties in adult rats. British Journal of Nutrition 76, 627–637.CrossRefGoogle ScholarPubMed
Department of Health (1991) ACNFP Guidelines on the Assessment of Novel Foods and Processes. Report on Health and Social Subjects no. 38.London: HM Stationery Office.Google Scholar
Dorhout, B, van Beusekom, M, Huisman, M, Kingma, AW, de Hoog, E, Boersma, ER & Muskiet, FAJ (1996) Estimation of twenty-four hour polyamine intake from mature human milk. Journal of Pediatric Gastroenterology and Nutrition 23, 298–302.Google Scholar
Dufour, C, Dandrifosse, G, Forget, P, Vermesse, F, Romain, N & Lepoint, P (1988)Spermine and spermidine induce intestinal maturation in the rat. Gastroenterology 95, 112–116.Google Scholar
Eaton, KK, Howard, M & McLaren-Howard, JMH (1995) Gut permeability measured by polyethylene glycol absorption in abnormal gut fermentation as compared with food intolerance. Journal of the Royal Society of Medicine 88, 63–66.Google ScholarPubMed
El Khefif, N, Peulen, O & Dandrifosse, G (1995) La spermine induit la prolifération de lymphocytes humains (Spermine induces the proliferation of human lymphocytes). Archives of Physiology and Biochemistry 103, D116.Google Scholar
Georges, P, Dandrifosse, G, Vermesse, F, Forget, P, Deloyer, P & Romain, N (1990) Reversibility of spermine-induced intestinal maturation in the rat. Digestive Diseases and Sciences 35, 1528–1536.CrossRefGoogle ScholarPubMed
Iynkaran, N & Yadav, M (1987) Food allergy. In Food Allergy. Immunopathology of the Small Intestine, pp. 415–449 [Marsch, MN, editor]. New York: John Wiley and Sons Ltd.Google Scholar
Juvonen, P, Jakobsson, I & Lindberg, T (1990) Macromolecular absorption and cows' milk allergy. Archives of Disease in Childhood 65, 300–303.Google Scholar
Kaouass, M, Deloyer, P & Dandrifosse, G (1993) Intestinal development in suckling rats: direct or indirect spermine action? Digestion 55, 160–167.CrossRefGoogle Scholar
Kaouass, M, Deloyer, P & Dandrifosse, G (1997a) Involvement of bombesin in spermine-induced corticosterone secretion and intestinal maturation in suckling rats. Journal of Endocrinology 153, 429–436.CrossRefGoogle ScholarPubMed
Kaouass, M, Deloyer, P, Gouders, I, Peulen, O & Dandrifosse, G (1997b) Role of interleukin-1 beta, interleukin-6, and TNF alpha in intestinal maturation induced by dietary spermine in rats. Endocrine 6, 187–194.CrossRefGoogle ScholarPubMed
Kaouass, M, Deloyer, P, Wery, I & Dandrifosse, G (1996) Analysis of structural and biochemical events occurring in the small intestine after dietary polyamine ingestion in suckling rats. Digestive Diseases and Sciences 41, 1434–1444.CrossRefGoogle ScholarPubMed
Kaouass, M, Sulon, J, Deloyer, P & Dandrifosse, G (1994) Spermine-induced precocious intestinal maturation in suckling rats: possible involvement of glucocorticoids. Journal of Endocrinology 141, 279–283.CrossRefGoogle ScholarPubMed
Laschet, J, El, Khefif N, Dandrifosse, G, Evrard, B, Minier, F, Moulinoux, JP, Seiler, N & Bureau, M (1998) Spermine and other polyamines as intracellular modulators of the endogenous phosphorylation of GABAA receptors. In Biologically Active Amines in Food. Vol. 2: Metabolic Effects of Biologically Active Amines, pp. 86–94 [Bardocz, S, White, A and Hajos, G, editors]. Luxembourg: European Commission Directorate-General XII Science, Research and Development.Google Scholar
Lessof, M (1993) Food Allergy and Other Adverse Reactions to Food. Brussels: ILSI Europe Publications.Google Scholar
Luk, GD, Marton, LJ & Baylin, SB (1980) Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats. Science 210, 195–198.Google Scholar
Pegg, AE (1986) Recent advances in the biochemistry of polyamines in eukaryotes. Biochemical Journal 234, 249–262.CrossRefGoogle ScholarPubMed
Peulen, O & Dandrifosse, G (1999) Cyclosporin A inhibits spermine induced differentiation but not cell loss of suckling rat small intestine. Digestive Diseases and Sciences (In the Press).Google Scholar
Peulen, O, Dewe, W, Dandrifosse, G, Henrottay, I & Romain, N (1998c) The relationship between spermine content of human milk during the first postnatal month and allergy in children. Public Health Nutrition 1, 184–188.CrossRefGoogle ScholarPubMed
Peulen, O, Muller, P, Defresne, M-P & Dandrifosse, G (1997) Spermine induced apoptosis in suckling rat small intestinal mucosa. Archives of Physiology and Biochemistry 105, 252–253.Google Scholar
Peulen, O, Muller, P, Gérard, P & Dandrifosse, G (1998a) Spermine-induced apoptosis in the small intestine of suckling rats. Archives of Physiology and Biochemistry 106, 1–29.Google Scholar
Peulen, O, Pirlet, C, Klimek, M & Dandrifosse, G (1998b) Comparison between the natural postnatal maturation and the spermine-induced maturation of the rat intestine. Archives of Physiology and Biochemistry 106, 46–55.CrossRefGoogle ScholarPubMed
Pollack, PF, Koldovsky, O & Nishioka, K (1992) Polyamines in human and rat milk and in infant formulas. American Journal of Clinical Nutrition 56, 371–375.CrossRefGoogle ScholarPubMed
Romain, N, Dandrifosse, G, Jeusette, F & Forget, P (1992) Polyamine concentration in rat milk and food, human milk and infant formulae. Pediatric Research 32, 58–63.CrossRefGoogle Scholar
Romain, N, Gesell, MS, Leroy, O, Forget, P, Dandrifosse, G & Luk, GD (1998) Effect of spermine administration on pancreatic maturation in unweaned rats. Comparative Biochemistry and Physiology 120A, 379–384.CrossRefGoogle ScholarPubMed
Starling, EH (1896) On the absorption of fluids from the connective tissue space. Journal of Physiology 19, 312–326.CrossRefGoogle Scholar
Ter, Steege JC, Buurman, WA & Forget, PP (1997) Spermine induces maturation of the immature intestinal immune system in neonatal mice. Journal of Pediatric Gastroenterology and Nutrition 25, 332–340.Google Scholar
Wery, I & Dandrifosse, G (1993) Evolution of biochemical parameters characterizing the proximal small intestine after orally administered spermine in unweaned rats. Endocrine Regulations 27, 201–207.Google ScholarPubMed
Wery, I, Deloyer, P & Dandrifosse, G (1996a) Effect of a single dose of orally-administered spermine on the intestinal development of unweaned rats. Archives Internationales de Physiologie et de Biochimie 104, 163–172.CrossRefGoogle ScholarPubMed
Wery, I, Kaouass, M, Deloyer, P, Buts, JP, Barbason, H & Dandrifosse, G (1996b) Exogenous spermine induces maturation of the liver in suckling rats. Hepatology 24, 1206–1210.Google ScholarPubMed
Wery, I, Romain, N & Dandrifosse, G (1992) Maturation intestinale précoce induite par la spermine chez le rat: cinétique et perméabilité intestinale (Early intestinal maturation induced by spermine in the rat: intestinal kinetics and permeability). Archives Internationales de Physiologie et de Biochimie 101, A135.Google Scholar