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All-trans-retinoic acid and polyriboinosinoic : polyribocytidylic acid cooperate to elevate anti-tetanus immunoglobulin G and immunoglobulin M responses in vitamin A-deficient Lewis rats and Balb/c mice

Published online by Cambridge University Press:  28 February 2007

Kathleen L. DeCicco  and
A. Catharine Ross
Kathleen L. DeCicco
Affiliation:
The Graduate Program in Nutrition and, The Pennsylvania State University, University Park, Pennsylvania, PA 16802, USA
A. Catharine Ross*
Affiliation:
Department of Nutrition, The Pennsylvania State University, University Park, Pennsylvania, PA 16802, USA
*
*Corresponding author:Professor A. Catharine Ross, fax +1 814 865 4723, email [email protected]
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Abstract

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Vitamin A (VA) deficiency compromises antibody responses to T-cell-dependent antigens such as tetanus toxoid, but this effect can be reversed through administration of retinol or retinoic acid (RA). To test whether RA and polyriboinosinioc : polyribocytidylic acid (PIC), a known inducer of several forms of interferon (IFN), can cooperate to increase specific immunoglobulin (Ig)G and IgM production during VA deficiency, rats and mice were made VA-deficient, immunized with TT and treated with all-trans-RA, PIC or their combination. VA-deficient rats produced low primary and secondary anti-tetanus IgG responses (VA-deficient controls v. VA-sufficient controls P < 0·001), although total IgG was slightly elevated when compared with VA-sufficient control rats. Although RA administered alone elevated antibody production during VA deficiency to control levels, RA combined with PIC synergistically enhanced these responses (RA and PIC group v. all other groups P < 0·0001). In contrast, Balb/c mice maintained on a VA-deficient diet and immunized in a similar fashion showed no impairment in antigen-specific IgG levels, but treatment with a combination of RA and PIC still evoked an additive enhancement in antigen-specific antibody production. Additionally, RA and PIC administration to VA-sufficient mice resulted in elevated antibody responses, suggesting that this combination should be evaluated further for its immuno-stimulatory effects.

Keywords

Vitamin ARetinoic acidPolyriboinosinic acidpolyribocytidylic acidInterferonAntibodies
Type
Symposium on ‘The molecular and cellular roles of nutrients in the immune system’
Information
Proceedings of the Nutrition Society , Volume 59 , Issue 4 , November 2000 , pp. 519 - 529
Copyright
Copyright © The Nutrition Society 2000

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