Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-22T15:17:45.790Z Has data issue: false hasContentIssue false

Alcohol, nutrition and health maintenance: selected aspects

Published online by Cambridge University Press:  07 March 2007

Paolo M. Suter*
Affiliation:
University Hospital, Medical Policlinic, Rämistrasse 100, 8091 Zürich, Switzerland
*
Corresponding author: Dr P. M. Suter, fax +41 43 233 97 26, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In view of the developments in health care relating to the increased prevalence and incidence of chronic diseases and the continuing increase in health-care expenditure, more attention should be paid to health maintenance and disease prevention. Any strategy that can influence health maintenance is of interest, especially lifestyle factors such as nutrition, exercise or stress control. Alcohol has an important place in the daily life of many healthy as well as sick individuals. Alcohol has three major characteristics; it is a nutrient (energy source), a psycho-active drug and a toxin. Each consumer has the choice of which of the characteristics of alcohol he/she wants to utilise. Thus, alcohol represents one of the most important self-implemented disease modifiers in our modern society. The major determinants of the health effects of alcohol are the absolute amount consumed, the consumption frequency, associated lifestyle factors (e.g. smoking, nutrient intake, substrate composition, physical activity pattern) and last, but not least, the genetic background. There are few known disease conditions that have not already been associated positively or negatively with alcohol consumption. The list of diseases includes atherosclerosis, dementia, diabetes, obesity and conditions relating to Zn metabolism. Obesity represents the most important disease modifier in the world and the prevalence rates are increasing rapidly. Evidence suggests that alcohol represents a risk factor for overweight and obesity as a result of specific effects on energy metabolism and substrate metabolism. The potential role of alcohol as an important modulator for the postprandial lipidaemia and its role in the pathogenesis of modern diseases will be discussed.

Type
Meeting Report
Copyright
Copyright © The Nutrition Society 2004

References

Agarwal, DP (2002) Cardioprotective effects of light–moderate consumption of alcohol: A review of putative mechanisms. Alcohol and Alcoholism 37, 409415.CrossRefGoogle ScholarPubMed
Austin, MA (1999) Epidemiology of hypertriglyceridemia and cardiovascular disease. American Journal of Cardiology 13, 13F16F.CrossRefGoogle Scholar
Berrigan, D, Dodd, K, Troiano, RP, Krebs-Smith, SM & Ballard-Barbash, R (2003) Patterns of health behavior in U.S. adults. Preventive Medicine 36, 615623.CrossRefGoogle ScholarPubMed
Bleich, S, Bleich, K, Kropp, S, Bittermann, HJ, Degner, D, Sperling, W, Ruther, E & Kornhuber, J (2001) Moderate alcohol consumption in social drinkers raises plasma homocysteine levels: a contradiction to the 'French Paradox'? Alcohol and Alcoholism 36, 189192.CrossRefGoogle Scholar
Boffetta, P & Garfinkel, L (1990) Alcohol drinking and mortality among men enrolled in an American Cancer society prospective study. Epidemiology 1, 342348.CrossRefGoogle Scholar
Boord, JB, Maeda, K, Makowski, L, Babaev, VR, Fazio, S, Linton, MF & Hotamisligil, GS (2002) Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arteriosclerosis, Thrombosis and Vascular Biology 22, 16861691.CrossRefGoogle ScholarPubMed
Bulpitt, CJ, Shipley, MJ & Semmence, A (1987) The contribution of a moderate intake of alcohol to the presence of hypertension. Journal of Hypertension 5, 8591.CrossRefGoogle Scholar
Burger, M, Mensink, GBM, Bergmann, E & Pietrzik, K (2003) Characteristics associated with alcohol consumption in Germany. Journal of Studies on Alcohol 64, 262269.CrossRefGoogle ScholarPubMed
Castro-Cabezas, M, Halkes, CJ & Erkelens, DW (2001) Obesity and free fatty acids: double trouble. Nutrition Metabolism and Cardiovascular Disease 11, 134142.Google ScholarPubMed
Choukroun, G, Schmitt, F, Martinez, F, Drüeke, T & Bankir, L (1997) Low urine flow reduced the capacity to excrete a sodium load in humans. American Journal of Physiology 273, R1726R1733.Google ScholarPubMed
Donahue, RP, Abbott, RD, Reed, DM & Yano, K (1986) Alcohol and hemorrhagic stroke. The Honolulu Heart Program. Journal of the American Medical Association 255, 23112314.CrossRefGoogle ScholarPubMed
Durstine, JL, Grandjean, PW, Cox, CA & Thompson, PD (2002) Lipids, lipoproteins, and exercise. Journal of Cardiopulmonary Rehabilitation 22, 385398.CrossRefGoogle ScholarPubMed
Esenabhalu, VE, Schaeffer, G & Graier, WF (2003) Free fatty acid overload attenuates Ca(2+) signaling and NO production in endothelial cells. Antioxidant Redox Signal 5, 147153.CrossRefGoogle ScholarPubMed
Folsom, AR, Nieto, FJ McGovern, PG Tsai, MY, Malinow, MR, Eckfeldt, JH, Hess, DL & Davis, CE (1998) Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins. The Atherosclerosis Risk in Communities (ARIC) Study. Circulation 98, 204210.CrossRefGoogle Scholar
Fraser, GE, Anderson, JT, Foster, N, Goldberg, R, Jacobs, D & Blackburn, H (1983) The effect of alcohol on serum high density lipoprotein (HDL). A controlled experiment. Atherosclerosis 46, 275286.CrossRefGoogle ScholarPubMed
Gallus, S, Bosetti, C, Franceschi, S, Levi, F, Negri, E & La-Vecchia, C (2003) Laryngeal cancer in women: tobacco, alcohol, nutritional, and hormonal factors. Cancer Epidemiology, Biomarkers and Prevention 12, 514517.Google ScholarPubMed
Ginsberg, HN (2002) New perspectives on atherogenesis: role of abnormal triglyceride-rich lipoprotein metabolism. Circulation 106, 21372142.CrossRefGoogle ScholarPubMed
Gotto, AM (2002) High-density lipoprotein cholesterol and triglycerides as therapeutic targets for preventing and treating coronary artery disease. American Heart Journal 144, Suppl. 6, S33S42.CrossRefGoogle ScholarPubMed
Halstred, CH (2001) Lifestyle effects on homocysteine and an alcohol paradox. American Journal of Clinical Nutrition 73, 501502.CrossRefGoogle Scholar
He, FJ & MacGregor, GA (2002) Effect of modest salt reduction on blood pressure: a meta-analysis of randomized trials. Implications for public health. Journal of Human Hypertension 17, 761770.CrossRefGoogle Scholar
Hines, LM, Stampfer, MJ, Ma, J, Gaziano, JM, Ridker, PM, Hankinson, SE, Sacks, F, Rimm, EB & Hunter, DJ (2001) Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. New England Journal of Medicine 344, 549555.CrossRefGoogle ScholarPubMed
Inter-Departmental Working Group (1995) Sensible Drinking. The Report of an Inter-Departmental Working Group 1995, pp. 1103. London: Department of Health.Google Scholar
Johnsen, SP, Overvad, K, Stripp, C, Tjonneland, A, Husted, SE & Sorensen, HT (2003) Intake of fruit and vegetables and the risk of ischemic stroke in a cohort of Danish men and women. American Journal of Clinical Nutrition 78, 5764.CrossRefGoogle Scholar
Joshipura, KJ, Ascherio, A, Manson, JE, Stampfer, MJ, Rimm, EB, Speizer, FE, Hennekens, CH, Spiegelman, D & Willett, WC (1999) Fruit and vegetable intake in relation to risk of ischemic stroke. Journal of the American Medical Association 282, 12331239.CrossRefGoogle ScholarPubMed
Joshipura, KJ, Hu, FB, Manson, JES, Tampfer, MJ, Rimm, EB, Speizer, FE, Colditz, G, Ascherio, A, Rosner, B, Spiegelman, D & Willett, WC (2001) The effect of fruit and vegetable intake on risk for coronary heart disease. Annals of Internal Medicine 134, 11061114.CrossRefGoogle ScholarPubMed
Klatsky, AL (1999) Is it the drink or the drinker? Circumstantial evidence only raises a probability. American Journal of Clinical Nutrition 69, 23.CrossRefGoogle ScholarPubMed
Klatsky, AL, Armstrong, MA & Friedman, GD (1986 a) Relations of alcoholic beverage use to subsequent coronary artery disease hospitalization. American Journal of Cardiology 58, 710714.CrossRefGoogle ScholarPubMed
Klatsky, AL, Armstrong, MA & Kipp, H (1990) Correlates of alcoholic beverage preference: traits of persons who choose wine, liquor or beer. British Journal of Addiction 85, 12791289.CrossRefGoogle ScholarPubMed
Klatsky, AL & Friedman, GD (1984) The role of alcohol in the epidemiology of hypertension: is alcohol associated hypertension a common preventable disease? Annals of Clinical Research 16, Suppl. 43, 8996.Google ScholarPubMed
Klatsky, AL, Friedman, GD & Armstrong, MA (1986 b) The relationship between alcoholic beverage use and other traits to blood pressure: a new Kaiser Permanente study. Circulation 73, 628636.CrossRefGoogle ScholarPubMed
Klatsky, AL, Friedman, GD, Siegelaub, AB & Gérard, MJ (1977) Alcohol consumption and blood pressure: Kaiser-Permanente multiphasic health examination data. New England Journal of Medicine 296, 11941200.CrossRefGoogle ScholarPubMed
Kleemen, C, Rubini, ME, Lamdin, E & Epstein, FH (1955) Studies on alcohol diuresis: II. The evaluation of ethyl alcohol ingestion on water, electrolyte and acid-base metabolism. Journal of Clinical Investigation 34, 439447.Google Scholar
Lamarche, B, Rashid, S & Lewis, GF (1999) HDL metabolism in hypertriglyceridemic states: an overview. Clinica Chimica Acta 286, 145161.CrossRefGoogle ScholarPubMed
Leppala, JM, Paunio, M, Virtamo, J, Fogelholm, R, Albanes, D, Taylor, PR & Heinonen, OP (1999) Alcohol consumption and stroke incidence in male smokers. Circulation 100, 12091214.CrossRefGoogle ScholarPubMed
Leppaluoto, JO, Vuolteenaho, O, Arjamaa, O & Ruskoaho, H (1992) Plasma immunoreactive atrial natriuretic peptide and vasopression after ethanol intake in man. Acta Physiologica Scandinavica 144, 121127.CrossRefGoogle Scholar
Listenberger, LL, Han, X, Lewis, SE, Cases, S, Farese, RV, Ory, DS & Schaffer, JE (2003) Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proceedings of the National Academy of Sciences USA 100, 30773082.CrossRefGoogle ScholarPubMed
MacDonald, I (1999) Health Issues Related to Alcohol Consumption, 2nd ed., pp. 1459. Brussels: ILSI Europe.Google Scholar
Maclure, M (1993) Demonstration of deductive meta-analysis: ethanol intake and risk of myocardial infarction. Epidemiologic Reviews 15, 328351.CrossRefGoogle ScholarPubMed
Mangoni, AA & Jackson, SH (2002) Homocysteine and cardiovascular disease: current evidence and future prospects. American Journal of Medicine 112, 556565.CrossRefGoogle ScholarPubMed
Meijssen, S, van-Dijk, H, Verseyden, C, Erkelens, DW & Cabezas, MC (2002) Delayed and exaggerated postprandial complement component 3 response in familial combined hyperlipidemia. Arteriosclerosis Thrombosis Vascular Biology 22, 811816.CrossRefGoogle ScholarPubMed
Miida, T, Nakamura, Y, Mezaki, T, Hanyu, O, Maruyama, S, Horikawa, Y, Izawa, S, Yamada, Y, Matsui, H & Okada, M (2002) LDL-cholesterol and HDL-cholesterol concentrations decrease during the day. Annals of Clinical Biochemistry 39, 241249.CrossRefGoogle ScholarPubMed
Mortensen, EL, Jensen, HH, Sanders, SA & Reinisch, JM (2001) Better psychological functioning and higher social status may largely explain the apparent health benefits of wine: a study of wine and beer drinking in young Danish adults. Archives of Internal Medicine 161, 18441848.CrossRefGoogle Scholar
Mukamal, KJ, Conigrave, KM, Mittleman, MA, Camargo, CA, Stampfer, MJ, Willett, WC & Rimm, EB (2003) Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. New England Journal of Medicine 348, 109118.CrossRefGoogle ScholarPubMed
Ness, AR & Powles, JW (1997) Fruit and vegetables, and cardiovascular disease: A review. International Journal of Epidemiology 26, 113.CrossRefGoogle ScholarPubMed
Nygard, O, Refsum, H, Ueland, PM & Vollset, SE (1998) Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. American Journal of Clinical Nutrition 67, 263270.CrossRefGoogle ScholarPubMed
Parks, EJ (2001) Recent findings in the study of postprandial lipemia. Current Atherosclerosis Reports 3, 462470.CrossRefGoogle Scholar
Petitt, DS & Cureton, KJ (2003) Effects of prior exercise on postprandial lipemia: a quantitative review. Metabolism 52, 418424.CrossRefGoogle ScholarPubMed
Potter, JF & Beevers, DG (1991) Factors determining the acute pressor response to alcohol. Clinical and Experimental Hypertension 13A, 1334.Google Scholar
Pownall, HJ, Ballantyne, CM, Kimball, KT, Simpson, SL, Yeshurun, D & Gotto, AM (1999) Effect of moderate alcohol consumption on hypertriglyceridemia. Archives of Internal Medicine 159, 981987.CrossRefGoogle ScholarPubMed
Refsum, H, Ueland, P, Nygard, O & Vollset, SE (1998) Homocysteine and cardiovascular disease. Annual Review of Medicine 49, 3162.CrossRefGoogle ScholarPubMed
Renaud, S, de Lorgeril, M (1992) Wine, alcohol, platelets, and the French paradox for coronary artery disease. Lancet 339, 15231526.CrossRefGoogle Scholar
Renaud, S & Gueguen, R (1998) The French paradox and wine drinking. In Alcohol and Cardiovascular Diseases, pp. 208222 [Chadwick, DJ and Goode, JA, editors]. Chichester: John Wiley & Sons.Google Scholar
Ruf, JC (1999) Wine and polyphenols related to platelet aggregation and atherothrombosis. Drugs under Experimental and Clinical Research 25, 125131.Google ScholarPubMed
Russell, M, Cooper, L, Frone, MR & Welte, JW (1991) Alcohol drinking patterns and blood pressure. American Journal of Public Health 81, 452457.CrossRefGoogle ScholarPubMed
Salaspuro, MP (2003) Alcohol consumption and cancer of the gastrointestinal tract. Best Practice and Research Clinical Gastroenterology 17, 679694.CrossRefGoogle ScholarPubMed
Segrest, JP (2002) The role of non-LDL:non-HDL particles in atherosclerosis. Current Diabetes Reports 2, 282288.CrossRefGoogle ScholarPubMed
Servoss, SJ, Januzzi, JL & Muller, JE (2002) Triggers of acute coronary syndromes. Progress in Cardiovascular Diseases 44, 369380.CrossRefGoogle ScholarPubMed
Silveira, A (2001) Postprandial triglycerides and blood coagulation. Experimental and Clinical Endocrinology & Diabetes 109, S527S532.CrossRefGoogle ScholarPubMed
Steinberg, HO & Baron, AD (2002) Vascular function, insulin resistance and fatty acids. Diabetologia 45, 623634.CrossRefGoogle ScholarPubMed
Suter, PM (2001 a) Alcohol: its role in health and disease. In Present Knowledge in Nutrition, pp. 497507 [Baumann, BB and Russell, RM, editors]. Washington, DC: ILSI Press.Google Scholar
Suter, PM (2001 b) Alcohol and mortality: if you drink, do not forget fruits and vegetables. Nutrition Reviews 59, 293297.CrossRefGoogle Scholar
Suter, PM Gerritsen Zehnder, M, Häsler, E, Gürtler, M, Vetter, W & Hänseler, E (2001) Effect of alcohol on postprandial lipemia with and without preprandial exercise. Journal of the American College of Nutrition 20, 5864.CrossRefGoogle ScholarPubMed
Suter, PM, Häsler, E & Vetter, W (1997) Effects of alcohol on energy metabolism and body weight regulation: Is alcohol a risk factor for obesity? Nutrition Reviews 55, 157171.CrossRefGoogle ScholarPubMed
Suter, PM, Jéquier, E & Schutz, Y (1993) Thermogenic effect of ethanol. FASEB Journal 7, A725.Google Scholar
Suter, PM, Jéquier, E & Schutz, Y (1994) The effect of ethanol on energy expenditure. American Journal of Physiology 266, R1204R1212.Google ScholarPubMed
Suter, PM, Maire, R & Vetter, W (1995) Is an increased waist:hip ratio the cause of alcohol-induced hypertension. The AIR94 study. Journal of Hypertension 13, 18571862.Google ScholarPubMed
Suter, PM, Schutz, Y & Jéquier, E (1992) The effect of ethanol on fat storage in healthy subjects. New England Journal of Medicine 326, 983987.CrossRefGoogle ScholarPubMed
Suter, PM & Vetter, W (2000) The effect of alcohol on blood pressure. Nutrition in Clinical Care 3, 2434.CrossRefGoogle Scholar
Taskinen, M-R & Nikkilä, EA (1977) Nocturnal hypertriglyceridemia and hyperinsulinemia following moderate evening intake of alcohol. Acta Medica Scandinavica 202, 173177.CrossRefGoogle ScholarPubMed
Taskinen, MR, Nikkilä, EA, Valimaki, M, Sane, T, Kuusi, T, Kesaniemi, A & Ylikahri, R (1987) Alcohol-induced changes in serum lipoproteins and in their metabolism. American Heart Journal 113, 458464.CrossRefGoogle ScholarPubMed
Thompson, PD, Buchner, D, Pina, IL, Balady, GJ, Williams, MA, Marcus, BH et al. (2003) Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation 107, 31093116.CrossRefGoogle ScholarPubMed
Trevisan, M, Krogh, V & Farinaro, E (1987) Alcohol consumption, drinking pattern and blood pressure: analysis of data from the Italian National Research Council Study. International Journal of Epidemiology 16, 520527.CrossRefGoogle ScholarPubMed
Tulenko, TN & Sumner, AE (2002) The physiology of lipoproteins. Journal of Nuclear Cardiology 9, 638649.CrossRefGoogle ScholarPubMed
Ueshima, H, Ozawa, H, Baba, S, Nakamoto, Y, Omae, T, Shimamoto, T & Komachi, Y (1992) Alcohol drinking and high blood pressure: data from a 1980 National Cardiovascular Survey of Japan. Journal of Clinical Epidemiology 45, 667673.CrossRefGoogle ScholarPubMed
Unger, RH (2003) The physiology of cellular liporegulation. Annual Reviews of Physiology 65, 333347.CrossRefGoogle ScholarPubMed
Wannamethee, SG, Camargo, CA, Manson, JE, Willett, WC & Rimm, EB (2003) Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women. Archives of Internal Medicine 163, 13291336.CrossRefGoogle ScholarPubMed
Wannamethee, SG & Sharper, AG (1998) Alcohol, coronary artery disease and stroke: an examination of the J-shaped curve. Neuroepidemiology 17, 288295.CrossRefGoogle Scholar
White, IR, Altmann, DR & Nanchahal, K (2002) Alcohol consumption and mortality: modelling risks for men and women at different ages. British Medical Journal 325, 191197.CrossRefGoogle ScholarPubMed
World Health Organization (2001) Healthy Life Expectancy. The World Health Report 2001. http://www3.who.int/whosis/hale/hale.cfm?path=whosis,burden_statistics,hale&language=english.accessed May 2003.Google Scholar
World Health Organization (2002) The European Health Report 2002. WHO European Series no. 97, pp. 1167. Copenhagen: WHO Regional Office for Europe.Google Scholar
Yli-Jama, P, Seljeflot, I, Meyer, HE, Hjerkinn, EM, Arnesen, H & Pedersen, JI (2002) Serum non-esterified very long-chain PUFA are associated with markers of endothelial dysfunction. Atherosclerosis 164, 275281.CrossRefGoogle ScholarPubMed
Ziegler, RG (1991) Vegetables, fruits, and carotenoids and the risk of cancer. American Journal of Clinical Nutrition 53, 251S259S.CrossRefGoogle ScholarPubMed
Zilkens, RR & Puddey, IB (2003) Alcohol and cardiovascular disease – more than one paradox to consider. Alcohol and type 2 diabetes – another paradox? Journal of Cardiovascular Risk 10, 2530.CrossRefGoogle ScholarPubMed
Zilversmit, DB (1979) Atherosclerosis: A postprandial phenomenon. Circulation 60, 473485.CrossRefGoogle Scholar
Zilversmit, DB (1995) Atherogenic nature of triglycerides, postprandial lipidemia, and triglyceride-rich lipoproteins. Clinical Chemistry 41, 153158.CrossRefGoogle Scholar