Observations at high-energies are important to define the first stages of the evolution of extragalactic radio sources and to characterize the interstellar medium of their host galaxies. In some of the X-ray-observed Compact Symmetric Objects (CSOs, among the youngest and most compact radio galaxies), we measured values of the total hydrogen column densities large enough to slow or prevent the radio source growth. The γ-ray window has the potential to constrain the non-thermal contribution of jets and lobes to the total high-energy emission. However, so far, young radio sources remain elusive in γ-rays, with only a handful of detections (or candidates) reported by Fermi. I present our γ-ray study of the CSO PKS 1718–649, and draw comparison with the restarted, γ-ray detected, radio galaxy 3C 84.