Wise mapped the entire sky in four bands during its approximately 7-month cryogenic mission. The number of exposures for each point on the sky increased with ecliptic latitude, and ranged from ~12 on the ecliptic to over 1000 at the ecliptic poles. The observing cadence is well suited to studying variable objects with periods between ~2 hours to ~2 days on the ecliptic, with the maximum period increasing up to several weeks near the ecliptic poles. We present the method used to identify several types of variables in the Wise Preliminary Release Database, and the mid-IR light curves of several objects. Many of these objects are new, and include RR Lyr, Algol, W UMa, Mira, BL Lac and YSO-type variables, as well as some unknown objects.