New HI synthesis observations have been made for the five spiral galaxies NGC 4307, NGC 4356, NGC 4411a/b and NGC 4492, located in the Virgo Cluster Region, with the Very Large Array in its CS configuration. All these objects, but NGC 4411a, belong to a sample of spirals identified in previous single-dish studies of the HI distribution within the Virgo Cluster and its outskirts. The thirteen members of that sample were selected for showing neutral gas deficiencies as strong as those of the inner galaxies of Virgo and other rich clusters, but apparently lying on the infall region.

The goal of the present observations is to progress further on the identification of the external mechanisms that may be responsible for the reduction of the interstellar gas in spiral galaxies and thus contribute to the study of the evolution of galaxies in high-density environments. In particular, the results of this work are relevant for the ongoing debate on the pre-processing of galaxies prior to entering the cluster environment.