In a subset of the most luminous of the so-called “ultra-luminous” X-ray sources in nearby galaxies, there is evidence for black holes with masses considerably higher than found in Galactic binaries. Apart from extremely high X-ray luminosities, cool disks found in the X-ray spectra of these sources and X-ray timing measurements form the basis for present evidence for intermediate-mass black holes in these sources. New optical and radio measurements appear to support the X-ray evidence. I will review recent X-ray, optical, and radio observations of these ULXs, and discuss the strengths of the intermediate-mass black hole interpretation, arguments against this interpretation, and future prospects for revealing the nature of these ULXS more clearly.