Feedback and outflows associated with a quasar phase are expected to be critical in quenching the most massive galaxies at high-z. Observations targeting the cool molecular and atomic phases, which dominate the mass and momentum budget of massive galaxy outflows and remove the direct fuel for star formation are, however, severely limited in high-z QSO hosts. We discuss two recent ALMA programs: one targeting molecular outflows in 3 z ∼ 6 QSO hosts using the OH 119 μm absorption line and another targeting the diffuse, predominantly atomic gas in the halos surrounding 5 QSO host between z ∼ 2 – 4 using the OH+(11 – 10) absorption line. Outflows are successfully detected in both samples and compared with outflows driven by high-z star-forming galaxies observed in the same lines. Both studies indicate that observing QSOs during the blow-out phase is crucial for studying the impact of the active nucleus on the ejection of gas from the host galaxy.