It is generally accepted that routine invasive husbandry procedures, such as disbudding and dehorning, cause considerable distress in farmed animals. In the case of dehorning, it has repeatedly been shown that calves exhibit many pain related symptoms both during (e.g., withdrawal from noxious stimulus) the procedure and for some hours post procedure (e.g., rearing, tripping, head rubbing, etc.). Little is known about the long-term consequences of dehorning as previous studies have only monitored responses for up to 48 hours. The objectives of this work were to examine the long-term response of calves to hot-iron dehorning and to determine the effectiveness of non-steroidal anti-inflammatory drugs (NSAID) for reducing post-operative distress.