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Leptin fully suppresses insulin secretion induced by acetylcholine and its effect is reversed by tolbutamide in in vitro perfused chicken pancreas

Published online by Cambridge University Press:  20 November 2017

Y. Benomar ,
M. Taouis  and
N. Rideau
Y. Benomar
Affiliation:
Station de Recherches Avicoles, INRA F37380 Nouzilly
M. Taouis
Affiliation:
Station de Recherches Avicoles, INRA F37380 Nouzilly
N. Rideau
Affiliation:
Station de Recherches Avicoles, INRA F37380 Nouzilly
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Extract

The chicken leptin cDNA has been cloned and sequenced (AF012727, AF082500) (Taouis et al., 2001) and in this species, the leptin messenger has been found to be expressed not only in adipose tissue but also in the liver. In mammals, circulating leptin acts through specific receptors (Ob-Rb) located in the region of hypothalamus that regulates feeding behavior and energy expenditure; Ob-Rb have also been identified in the pancreatic ß-cells that produce insulin supporting evidence that leptin directly regulates insulin release (Kieffer et al. 2000). A direct effect of leptin on peripheral target tissues has not yet been demonstrated in chicken. The work was designed to study the effect of recombinant chicken leptin on acetylcholine-induced insulin secretion by isolated perfused chicken pancreas.

Type
Poster Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2002 , 2002 , pp. 98
Copyright
Copyright © The British Society of Animal Science 2002

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References

Kieffer, T. J., and J. F., Habener. 2000. The adipoinsular axis: effects of leptin on pancreatic beta-cells. Am J Physiol Endocrinol Metab 278: E1–E14 Google Scholar
Rideau, N., J., Simon, and B., Leclercq. 1986. Further characterization of insulin secretion from the perfused duodenum-pancreas of chicken: a comparison of insulin release in chickens selected for high and low abdominal fat content. Endocrinology 119: 2635-41Google Scholar
Taouis, M.; Dridi, S.; Cassy, S.; Benomar, Y.;Raver, N.Rideau, Picard, M.; Williams, J.; Gertler, A. 2001. Chicken leptin: properties and action. Domestic Animal Endocrinology, 21: in press.Google Scholar