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Exploration of somatotropic axis, leptin, insulin and blood biochemical parameters in ewes naturally affected with scrapie

Published online by Cambridge University Press:  20 November 2017

V. Gayrard ,
N. Picard-Hagen ,
C. Viguié ,
C. Delavaud ,
P.L. loutam  and
Y. Chilhard
V. Gayrard
Affiliation:
UMR INRA de Physiopathologie et Toxicologie Expérimentales, Ecole Nationale Vétérinaire de Toulouse, 31076 Toulouse, France
N. Picard-Hagen
Affiliation:
UMR INRA de Physiopathologie et Toxicologie Expérimentales, Ecole Nationale Vétérinaire de Toulouse, 31076 Toulouse, France
C. Viguié
Affiliation:
UMR INRA de Physiopathologie et Toxicologie Expérimentales, Ecole Nationale Vétérinaire de Toulouse, 31076 Toulouse, France
C. Delavaud
Affiliation:
Unité de Recherche sur les Herbivores, INRA Theix, 63122 St Genès-Champanelle, France
P.L. loutam
Affiliation:
UMR INRA de Physiopathologie et Toxicologie Expérimentales, Ecole Nationale Vétérinaire de Toulouse, 31076 Toulouse, France
Y. Chilhard
Affiliation:
Unité de Recherche sur les Herbivores, INRA Theix, 63122 St Genès-Champanelle, France
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Extract

Scrapie is an ovine sub-acute transmissible spongiform encephalopathy (TSE) caused by unconventional transmissible agents. In several species, TSE are associated to major endocrinopathy, such as hyperinsulinemia and hypercorticism (Carp et al, 1990, Gayrard et al, 2000). Cachexia is commonly observed in the clinical phase of the prion disease. Our objective was to investigate if scrapie is associated to alterations of GH axis, leptin, insulin and metabolic parameters. In addition, central adrenergic system being affected in TSE (Braun et al, 1999), we investigated a possible alteration of α2-adrenergic control of GH axis associated to the prion disease.

Type
Poster Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2002 , 2002 , pp. 88
Copyright
Copyright © The British Society of Animal Science 2002

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References

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