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The effect of the source of dietary supplemental zinc on tissue copper concentrations in the rat

Published online by Cambridge University Press:  05 November 2021

J.A. Lowe  and
J Wiseman
J.A. Lowe
Affiliation:
Gilbertson & Page, 45-55 Brownfields, Welwyn Garden City, Herts A17 1LF, UK University of Nottingham, Sutton Bonington Campus, Loughborough, Leics, LE12 5RD, UK.
J Wiseman
Affiliation:
University of Nottingham, Sutton Bonington Campus, Loughborough, Leics, LE12 5RD, UK.
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Extract

Hill and Matrone (1970) postulated that chemically similar minerals would manifest biological similarity. As a result there would be competitive antagonism for inclusion in metabolic processes, including intestinal transport. Such interactions have been reported for copper (Cu) and zinc (Zn), where the chronic over supply of Zn reduced Cu absorption (Fischer, Giroux and L'Abbe 1981). Previous work ( Lowe, Wiseman and Cole 1994) has indicated that when Zn is supplied as a chelate that antagonism to its absorption from calcium may be overcome. As many diets, specifically for piglets, now appear to contain very high levels of supplementary Zn it is appropriate to evaluate the effects of its dietary supplemental source on other mineral uptake.

24 adult female CD rats (327g, SE 4.7) were randomly divided into four groups and fed a maintenance diet (27.mg. kg-1 Cu) on a free choice basis containing 28mgZn.kg-1 to which 65mg of supplemental Zn.kg-1 from four different sources was added for the duration of the study.

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Programme
Information
Proceedings of the British Society of Animal Science , Volume 1997 , 1997 , pp. 67
Copyright
Copyright © British Society of Animal Science 1997

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References

Hill, C. H. and Matorne, G. 1970. Chemical parameters in the study of in vivo and in vitro, interactions of transition elements Federal Proceedings 29: 1474.Google Scholar
Lowe, J.A., Wiseman, J. and Cole, D.J.A. 1994. Zinc source influences zinc Retention in hair and hair growth in the dog.. Journal of Nutrition 124: 2575 CrossRefGoogle ScholarPubMed
Fischer, P. W. F., Giroux, A. and L'Abbe, M.R. 1983. Effects of zinc on mucosal copper binding and on the kinetics of copper absorption Journal of Nutrition 113: 462 CrossRefGoogle ScholarPubMed