Hostname: page-component-6bf8c574d5-qdpjg Total loading time: 0 Render date: 2025-02-14T23:44:08.753Z Has data issue: false hasContentIssue false
  • English
  • Français

Characterisation and mapping of the Booroola (FecB) gene using regression analysis in sheep

Published online by Cambridge University Press:  20 November 2017

G.A. Walling ,
K.G. Dodds ,
S.M. Galloway ,
A.E. Beattie ,
E.A. Lord ,
J.M. Lumsden ,
G.W. Montgomery  and
J.C. McEwan
G.A. Walling
Affiliation:
AgResearch, Invermay Agricultural Centre, Private Bag 50034, Mosgiel, New Zealand
K.G. Dodds
Affiliation:
AgResearch, Invermay Agricultural Centre, Private Bag 50034, Mosgiel, New Zealand
S.M. Galloway
Affiliation:
AgResearch Molecular Biology Unit, Department of Biochemistry and Centre for Gene Research, University of Otago, P.O. Box 56, Dunedin, New Zealand
A.E. Beattie
Affiliation:
AgResearch, Invermay Agricultural Centre, Private Bag 50034, Mosgiel, New Zealand
E.A. Lord
Affiliation:
AgResearch, Invermay Agricultural Centre, Private Bag 50034, Mosgiel, New Zealand
J.M. Lumsden
Affiliation:
AgResearch Molecular Biology Unit, Department of Biochemistry and Centre for Gene Research, University of Otago, P.O. Box 56, Dunedin, New Zealand
G.W. Montgomery
Affiliation:
Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4029, Australia
J.C. McEwan
Affiliation:
AgResearch, Invermay Agricultural Centre, Private Bag 50034, Mosgiel, New Zealand
Get access

Extract

The Booroola Merino strain of sheep carries a major autosomal mutation (FecB) which increases ovulation rate (Davis et al., 1982). To map the gene, heterozygous sires (B+) were mated to non-carrier ewes (++). The female progeny were then examined by laproscopy to determine ovulation rates and these phenotypes used to assign progeny genotypes (B+, ++ or undetermined). Linkage analysis between the assigned Booroola genotype and a set of marker genotypes was used to assign the Booroola gene to a region of sheep chromosome 6 (OOV6) (Montgomery et al., 1994). These studies relied on accurate genotype assignment and a constant gene effect across animals and breeding seasons. This study aims to use regression analysis to verify the validity of these assumptions.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2000 , 2000 , pp. 41
Copyright
Copyright © The British Society of Animal Science 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Davis, G.H., Montgomery, G.W., Allison, J.A., Kelly, R.W. and Bray, A.R. 1982. Segregation of a major gene influencing fecundity in progeny of Booroola sheep. New Zealand Journal of Agricultural Research 25: 525–529 Google Scholar
Dodds, K.G. 1999. Haley-Knott regression mapping of quantitative trait loci in extended pedigrees. Proceedings of the Association for the Advancement of Animal Breeding and Genetics 13: 313–316.Google Scholar
Montgomery, G.W. and Hawker, H. 1987. Seasonal reproduction in ewes selected on seasonal changes in wool production. Journal of Reproductive Fertility 79: 207–213.Google Scholar
Montgomery, G.W., Lord, E.A., Penty, J.M., Dodd, K.G., Broad, T.E., Cambridge, L., Sunden, S.L.F., Stone, R.T. and Crawford, A.M. 1994. The Booroola fecundity (FecB) gene maps to sheep chromosome 6. Genomics 22: 148–153.Google Scholar