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Successful lactation in leptin-deficient obese (ob/ob) mice

Published online by Cambridge University Press:  20 November 2017

C. H. Knight ,
E. Ong ,
R.G. Vernon  and
A. Sorensen
C. H. Knight
Affiliation:
Hannah Research Institute, Ayr KA6 5HL, U.K.
E. Ong
Affiliation:
Hannah Research Institute, Ayr KA6 5HL, U.K.
R.G. Vernon
Affiliation:
Hannah Research Institute, Ayr KA6 5HL, U.K.
A. Sorensen
Affiliation:
Hannah Research Institute, Ayr KA6 5HL, U.K.
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Extract

Mice lacking a functional leptin gene (ob/ob) are obese and sterile. Treatment with exogenous leptin will restore fertility and allow full-term pregnancy, but when leptin is withdrawn at parturition the young die, apparently as a result of total lactation failure (Chehab et al., 1996). From this one could hypothesise that leptin is an essential requirement for mammary development and/or initiation of milk secretion. Since a few of the mice used in this work were subsequently able to rear pups following a second pregnancy and parturition, we decided to re-examine this hypothesis.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2002 , 2002 , pp. 4
Copyright
Copyright © The British Society of Animal Science 2002

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References

Chehab, F. F., Lim, M. E. and Lu, R. 1996. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 12: 318–320.CrossRefGoogle ScholarPubMed