Naturally grown in the vast majority of Brazilian territory, Solanum lycocarpum (SL, popularly known as wolf’s apple) can be used as alternative feed additive for ruminants. Despite its significant amount of secondary metabolites, it is known to be eaten by cattle and a specific species of wild wolf (Chrysocyon brachyurus). However the effects of these organic compounds on ruminal fermentation are still unclear and a dose-response is expected to turn a potential feedstock into an undesirable baneful aliment (Goel et al., 2008). As a result scientific investigation regarding this highly promising plant is needed to test its potential as a supplement to support sustainable livestock production systems. Thus this study compared the effects of different dried meal-like fractions (fruit, leaf, flower, root, stem) of this plant at two different levels (0.2 and 0.4 g) on the in vitro dry matter (DM) degradability (IVD) at three different times of incubation.