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Effects of different Cortisol profiles on immune function in sheep

Published online by Cambridge University Press:  05 November 2021

S. M. Rhind ,
H. W. Reid  and
S. R. McMillen
S. M. Rhind
Affiliation:
Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB15 8QH, United Kingdom
H. W. Reid
Affiliation:
Moredun Research Institute, 408 Gilmerton Road, Edinburgh EH17 7JH, United Kingdom
S. R. McMillen
Affiliation:
Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB15 8QH, United Kingdom
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Extract

Cortisol has been implicated in the mediation of both stimulatory and inhibitory effects of stessors on immune function in domestic animals, depending on the rate of secretion (Griffin, 1989; Munck, Guyre and Holbrook, 1984). Stressors differ in intensity and duration and it is likely that blood Cortisol profiles will differ accordingly. However, the importance, with respect to immune function, of the magnitude, duration and frequency of increases in circulating corticosteroid concentration is unknown. The aim of this study was to determine the effect of different profiles of Cortisol in the peripheral circulation, on antibody and cell mediated immune responses.

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Information
Proceedings of the British Society of Animal Science , Volume 1997 , 1997 , pp. 190
Copyright
Copyright © British Society of Animal Science 1997

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References

Griffin, J.F.T. 1989. Stress and immunity: a unifying concept. Veterinary Immunology and Immunopathology 20 263–312.CrossRefGoogle ScholarPubMed
Munck, A., Guyre, P.M. and Holbrook, N.J. 1984. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocrine Reviews 5 25– 44.CrossRefGoogle ScholarPubMed