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Effect of biotin on growth, viability and apparent DNA synthesis in cultured secondary hair follicles of the Angora goat

Published online by Cambridge University Press:  05 November 2021

A.M. Tahmasbi ,
H. Galbraith  and
J.R. Scaife
A.M. Tahmasbi
Affiliation:
Department of Agriculture., Aberdeen University, 581 King Street, Aberdeen, Scotland, AB24 5UD
H. Galbraith
Affiliation:
Department of Agriculture., Aberdeen University, 581 King Street, Aberdeen, Scotland, AB24 5UD
J.R. Scaife
Affiliation:
Department of Agriculture., Aberdeen University, 581 King Street, Aberdeen, Scotland, AB24 5UD
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Extract

Biotin is a water soluble vitamin which has a well proven function in corboxylation reactions in animal tissues. It is well documented that biotin deficiency in mammals causes pathological changes in the skin and its appendages such as desquamative dermatitis and alopecia. Previous work (Tahmasbi et al 1996) has suggested that deficiency of biotin in the culture medium reduced the viability of wool hair follicles in vitro by mechanisms unknown, but which may involve interference with cell division and or differentiation. The objective of this work was to investigate the effect of biotin deficiency and adequacy on cell proliferation and DNA synthesis as determined by incorporation of [methyl-3H]thymidine in isolated mohair follicles.

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Programme
Information
Proceedings of the British Society of Animal Science , Volume 1998 , 1998 , pp. 138
Copyright
Copyright © The British Society of Animal Science 1998

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References

Tahmasbi, A.M., Galbraith, H., Scaife, J.R. 1996. Development of an In Vitro technique to investigate the role of biotin in regulation wool growth in sheep. Animal Science. 62: 671–672 (abstr) Google Scholar