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The effect of a polymorphism in the MC4R gene within a Meishan synthetic line of pigs

Published online by Cambridge University Press:  20 November 2017

M. Wilson ,
O.I. Southwood  and
G.S. Plastow
M. Wilson
Affiliation:
Sygen International plc, 2 Kingston Business Park, Kingston Bagpuize, Oxfordshire OX13 5FE, UK
O.I. Southwood
Affiliation:
Sygen International plc, 2 Kingston Business Park, Kingston Bagpuize, Oxfordshire OX13 5FE, UK
G.S. Plastow
Affiliation:
Sygen International plc, 2 Kingston Business Park, Kingston Bagpuize, Oxfordshire OX13 5FE, UK
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Extract

The effect of a DNA polymorphism in the MC4R gene on fatness, growth and feed intake traits of pigs was first reported by Kim et al in 2000 (1). That study of 1720 animals showed significant effects in several selected breeding populations for days to 110kgs (p<.001), 10th rib backfat (p<.001), test daily gain (p<.001) and feed intake (p<.01). However, in the same paper the effect within a small sample (124) from a Meishan synthetic line was not significant and the (small) effect of backfat was in the opposite direction to that reported for other lines. Subsequently, Andersson and colleagues (2) reported a failure to detect an effect in a small QTL population derived from crossing Large White pigs with wild boar. Several explanations have been proposed (1,2) including an epistatic effect. Here we report the results of an experiment to test whether the results from the Meishan population was due to sampling. The results indicated an effect of MC4R within the Meishan line for fatness, growth and feed intake traits in the same direction as previously reported for other lines.

Type
Poster Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2004 , 2004 , pp. 227
Copyright
Copyright © The British Society of Animal Science 2004

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References

1. Kim, KS, Larsen, N, Short, T, Plastow, GS, Rothschild, MF, (2000) A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamalian Genome 11: 131–135 CrossRefGoogle ScholarPubMed
2. Park, HB, Carlborg, O, Marklund, S, Andersson, L, (2002) Melanocortin-4 receptor (MC4R) genotypes have no major effect on fatness in a Large White x Wild Boar intercross. Animal Genetics 33:155–157 Google Scholar
3. Kerr, RJ, Kinghorn, BP, (1996) An efficient algorithm for segregation analysis in large populations J. Animal Breeding and Genetics 113: 457–469 Google Scholar
4. Groeneveld, E, Kovac, M, Wang, T (1990) PEST, a general purpose BLUP package for multivariate prediction and estimation. 4th Genetic World Congress, Edinburgh. XIII:488–491 Google Scholar