Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-27T07:55:38.308Z Has data issue: false hasContentIssue false
  • English
  • Français

Autocrine control of milk secretion by a milk protein

Published online by Cambridge University Press:  24 November 2017

C.J. Wilde ,
C.V.P. Addey ,
F.M. Campbell ,
S.A. Connor ,
M.A. Kerr  and
C.H. Knight
C.J. Wilde
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
C.V.P. Addey
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
F.M. Campbell
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
S.A. Connor
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
M.A. Kerr
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
C.H. Knight
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
Get access

Extract

The rate of milk secretion is controlled acutely by the frequency and completeness of milk removal from the mammary gland. Numerous experiments in dairy animals have shown that this acute control is exerted locally within each gland, rather than by circulating galactopoietic hormones (Wilde & Peaker, 1990). Local regulation of milk secretion by milk removal is not related to physical distension of the gland by accumulated milk (Henderson & Peaker, 1984), but is instead the result of changes in the degree of chemical feedback inhibition exerted by a secreted milk constituent.

Proteins that may act as feedback inhibitors of lactation (FIL) have been isolated from goat's milk (Addey et al, 1991a), cow's milk (Addey et al, 1991b) and human milk (Wilde, unpublished work) on the basis of their ability to inhibit synthesis of milk constituents in a rabbit tissue explant bioassay (Wilde et al, 1987a).

Type
The Application of Molecular Biology to Animal Science
Information
Proceedings of the British Society of Animal Production (1972) , Volume 1993: Winter meeting , March 1993 , pp. 159
Copyright
Copyright © The British Society of Animal Production 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Addey, C.V.P., Peaker, M. & Wilde, C.J. (1991a) Control of milk secretion. UK Patent Application 8925594. Google Scholar
Addey, C.V.P., Peaker, M. & Wilde, C.J (1991b) Control of secretion of milk. UK Patent Application 8925595.Google Scholar
Bennett, C.N., Knight, C.H. & Wilde, C.J. (1990) Regulation of mammary prolactin binding by secreted milk proteins. Journal of Endocrinology 124 (Suppl.), 134.Google Scholar
Dewhurst, R.D. & Knight, C.H. (1992) The response to thrice-daily milking and its relationship to cisternal storage capacity in dairy cows. Animal Production 54, 459.Google Scholar
Henderson, A.J. & Peaker, M. (1984) Feedback control of milk secretion in the goat by a chemical in milk. Journal of Physiology 351, 39–45.Google Scholar
Henderson, A.J. & Peaker, M. (1987) Effects of removing milk from the mammary ducts and alveoli, or of diluting stored milk, on the rate of milk secretion in the goat. Quarterly Journal of Experimental Physiology 72, 13–19.Google Scholar
Knight, C.H., Brosnan, T., Wilde, C.J. & Peaker, M. (1989) Evidence for a relationship between grosss mammary anatomy and the increase in milk yield obtained during thrice daily milking in goats. Journal of Reproduction and Fertility (abstract series) 5, 30.Google Scholar
Peaker, M. & Blatchford, D.R. (1988) Distribution of milk in the goat mammary gland and its relation to the rate and control of milk secretion. Journal of Dairy Research 55, 41–48.Google Scholar
Wilde, C.J., Blatchford, D.R. & Peaker, M. (1991) Regulation of mouse mammary cell differentiation by extracellular milk proteins. Experimental Physiology 76, 379–387.Google ScholarPubMed
Wilde, C.J., Calvert, D.T., Daly, A. & Peaker, M. (1987a) The effect of goat milk fractions on synthesis of milk constituents by rabbit mammary explants and on milk yield in vivo. Biochemical Journal 242, 285–288.Google Scholar
Wilde, C.J., Henderson, A.J., Knight, C.H., Blatchford, D.R., Faulkner, A. & Vernon, R.G. (1987b) Effects of long-term thrice-daily milking on mammary enzyme activity, cell population and milk yield. Journal of Animal Science 64, 533–539.Google Scholar
Wilde, C.J., Knight, C.H., Addey, C.V.P., Blatchford, D.R., Travers, M., Bennett, C.N. & Peaker, M. (1990) Autocrine regulation of mammary cell differentiation. Protoplasma 159, 112–117.Google Scholar
Wilde, C.J. & Peaker, M. (1990) Autocrine control in milk secretion. Journal of Agricultural Science 114, 235–238.Google Scholar