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Systematic Studies of Cerebral Resuscitation Potentials after Global Brain Ischemia (GBI)

Published online by Cambridge University Press:  28 June 2012

Sven Erik Gisvold  and
Peter Safar
Sven Erik Gisvold
Affiliation:
From the Resuscitation Research Center and the Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh, Pittsburgh PA 15260, USA.
Peter Safar
Affiliation:
From the Resuscitation Research Center and the Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh, Pittsburgh PA 15260, USA.
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Extract

Resuscitation of the brain after ischemic-anoxic brain injury remains a controversial topic. There is, however, presently a certain therapeutic optimism in this field. Ours is partly based on the recognition of a post-resuscitation disease, that is, treatable pathologic processes in all organs after restoration of adequate perfusion pressure and arterial oxygenation. Also, Hossmann has shown that neurons can survive longer periods of anoxia than previously assumed.

There have been reports on experimental focal ischemia indicating beneficial effects of barbiturates and moderate hemodilution before and after initiation of focal ischemia. After complete temporary global brain ischemia (GBI), as in cardiac arrest, however, results so far have been conflicting and controversial.

Type
Part II: Clinical Care Topics
Information
Prehospital and Disaster Medicine , Volume 1 , supplement S1: Disaster Resuscitology , 1985 , pp. 255 - 260
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1985

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References

1. Negovsky, VA. General problems of the post-resuscitation pathology of the brain. Resuscitation 1979;7:73.CrossRefGoogle ScholarPubMed
2. Hossmann, KA,Kleihues, P. Reversibility of ischemic brain damage. Arch Neural 1973;29:375.CrossRefGoogle ScholarPubMed
3. Smith, AL. Hoff, JT, Nielson, SL. Barbiturate protection against cerebral infarction. Stroke 1974;5:1.CrossRefGoogle Scholar
4. Michenfelder, JD, Milde, HC, Sundt, TM Jr, Cerebral protection by barbiturate anesthesia. Use after middle cerebral artery occlusion in Java monkeys. Arch Neural 1976;33:345.CrossRefGoogle ScholarPubMed
5. Gilroy, J, Barnhart, N, Meyer, J. Treatment of acute stroke with dextran. JAMA 1969;210:293.CrossRefGoogle ScholarPubMed
6. Ames, A III, Wright, RL, Kowada, M et al. Cerebral ischemia. II The noreflow phenomenon. Am J Pathol 1968;52:437.Google Scholar
7. Fischer, EG, Ames, A III.Studies on mechanisms of impairment of cerebral circulation following ischemia: Effect of hemodilution and perfusion pressure. Stroke 1972;3:538.CrossRefGoogle ScholarPubMed
8. Nemoto, EM, Erdmann, W, Strong, E et al. Regional brain PO2after global ischemia in monkeys: Evidence for regional differences in critical perfusion pressures. Stroke 1979;10:44.CrossRefGoogle Scholar
9. Safar, P. Stezoski, W, Nemoto, EM. Amelioration of brain damage after 12 minutes cardiac arrest in dogs. Arch Neurol 1976;33:91.CrossRefGoogle ScholarPubMed
10. Nemoto, EM,Bleyaert, AL, Stezoski, W et al. Global brain ischemia. A reproducible monkey model. Stroke 1977;8:558.CrossRefGoogle ScholarPubMed
11. Safar, Petal. Treatment of hypoperfusion after global brain ischemia (GBI) in dogs and monkeys. Circulatory Shock 1980;7:200. Abstract No. 26.Google Scholar
12Bleyaert, A, Sands, P, Safar, P et al. Augmentation of postischemic brain damage by severe intermittent hypertension. Crit Care Med 1980;8:41.CrossRefGoogle ScholarPubMed
13. Bleyaert, A, Safar, P, Nemoto, E et al. Blood pressure control after cardiac arrest (abstract). Crit Care Med 1978;6:92.CrossRefGoogle Scholar
14. Nemoto, E, Bleyaert, A, Stezoski, W et al. Amelioration of postischemicanoxic brain damage by thiopental. In Safar, P, Advances in CPR. New York: Springer, 1977.Google Scholar
15. Bleyaert, A, Safar, P. Nemoto, E et al. Effect of postcirculatory arrest lifesupport on neurological recovery in monkeys. Crit Care Med 1980;8:153.CrossRefGoogle ScholarPubMed
16. Fujishima, M, Kiyohara, J, Ishitsuka, T et al. Effects of hematocrit oncerebral circulation and metabolism in experimental cerebral ischemia. J Cerebral Blood Flow and Metabolism 1981;1 (suppl 1):249.Google Scholar
17. Gisvold, SE, Safar, P, Hendrickx, H et al. Thiopental treatment after global brain ischemia in monkeys. Anesthesiology 1981;Suppl (abstract), in press.Google Scholar
18. Bleyaert, AL, Safar, P, Stezoski, W et al. Amelioration of postiachemia brain damage in the monkey by immobilization and controlled ventilation. Crit Care Med 1978;6:112 (abstract).CrossRefGoogle Scholar
19. Gisvold, SE, Safar, P, Alexander, H et al. Noameliorationof post-anoxic brain damage by immobilization and IPPV in monkeys. Crit Care Med 1981;9:183 (abstract).CrossRefGoogle Scholar
20. Hendrickx, H, Gisvold, SE, Safar, P et al. A new cardiac arrest rat model for brain resuscitation studies. J Cerebral Blood Flow and Metabolism 1981;1 (suppl 1):222.Google Scholar