To even pose the question, “Can you do worthwhile pathophysiological research on critically injured patients?” practically suggests that we give up and surrender a field of medical science that is both challenging and laden with potential. Rather we should be posing the question, “Can we really afford not to be doing this research?” The purists of science must shudder when they think of trying to make sense out of the apparent chaos which surrounds a victim of multiple trauma. Sometimes we do as well, but perhaps we cannot afford to turn our backs because our egos perk at the recognized challenge. Perhaps we look at the heart-rending deterioration of a previously healthy 20–year old and say to ourselves, “What can I do differently the next time?” For these reasons and more, we all continue in our endeavors.