Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-26T03:48:59.306Z Has data issue: false hasContentIssue false

Is the Use of Calcium Helpful in Cardiac Resuscitation? Experimental and Clinical Studies

Published online by Cambridge University Press:  28 June 2012

G. Meuret
Affiliation:
From the Institut für Anaesthesiologie der Klinken derUniversität, Abteilung für Experimentelle Anaesthesiologie, Freiburg, FRG.
V. Roth
Affiliation:
From the Institut für Anaesthesiologie der Klinken derUniversität, Abteilung für Experimentelle Anaesthesiologie, Freiburg, FRG.
D. Borcherding
Affiliation:
From the Institut für Anaesthesiologie der Klinken derUniversität, Abteilung für Experimentelle Anaesthesiologie, Freiburg, FRG.
K. L. Scholler
Affiliation:
From the Institut für Anaesthesiologie der Klinken derUniversität, Abteilung für Experimentelle Anaesthesiologie, Freiburg, FRG.

Extract

The effect of positive inotropic agents on circulation and ventricular fibrillation threshold are not fully understood during the influence of metabolic acidosis during circulatory arrest. This is the same case with alkalosis, caused by the over-correction of sodium bicarbonate. Furthermore, the role of calcium during CPR is not clear.

Therefore, we investigated the influence of metabolic acidosis and alkalosis with and without the administration of the positive inotropic substances epinephrine and calcium upon contractility and ventricular fibrillation threshold.

Type
Part II: Clinical Care Topics
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Anderson, MN, Border, JR, Mouritzon, CV. Acidosis, catecholamines and cardiovascular dynamics: When acidosis requires correction? Ann Surg 1967;166:344.CrossRefGoogle Scholar
2. Redding, JS. Drug therapy during cardiac arrest. In Safar, P (ed). Advances in Cardiopulmonary Resuscitation. New York: Springer, 1977;113–117, 137138.Google Scholar
3. Rackwitz, R, Jahrmarker, J, Theisen, K et al. Pathogenese und Therapie der Acidose bei Reanimation. Intensivmcdizin 1975;12:1.Google Scholar
4. Younossi, K, Rüdiger, JJ, Haap, KP et al. Untersuchugen liber die Flimmerschwelle des isolierten Meerschweinchen —Herzens fur Gleichstrom und sinusförmigen Wechselstrom. Basic Res Cardio 1973 69:551,568.Google Scholar
5. Ruigrok, TJC, Burgersdijk, FJA, Zimmerman, ANE. The calcium paradox: A reaffirmation. Eur J Cardiol 1975;3:5963.Google ScholarPubMed
6. Roberts, JR,Greenberg, MJ, Knaub, MA. Blood levels following intravenous and endotrachealepinephrine administration. JACEP 1979;8:5356.CrossRefGoogle ScholarPubMed
7. Bishop, RL, Weisfeldt, ML. Sodium bicarbonate administration during cardiac arrest. JAMA 1976;235:506509.CrossRefGoogle ScholarPubMed
8. Schaer, RL. Decrease in ionized calcium by bicarbonate in physiological solutions. Pflugers Arch 1974;347:249254.CrossRefGoogle ScholarPubMed
9. Eliot, RS, Blount, SG Jr, Calcium, chelatesand digitalis —a clinical study. Am Heart J 1961;62:721.CrossRefGoogle ScholarPubMed
10. Fleckenstein, A, Janke, Y, Doring, HJ et al. Key role of Ca in the production of noncoronarogenic myocardial necroses. Rec Adv Stud Cardiol Struct Metab 1975;6:2131.Google ScholarPubMed
11. Nayler, WG, Ferrari, F, Slade, A. Cardioprotective actionsof calcium—antagonists in myocardial anoxia and ischemia. In Fleckenstein, A, Roskamm, H (eds). Calcium —Antagonismus. New York: Springer, 1980;128.Google Scholar