Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-23T09:44:44.847Z Has data issue: false hasContentIssue false

Emergency Treatment of Anaphylactic Reactions in Air Rescue Missions: An Eight-Year Analysis of a German Rescue Helicopter Base

Published online by Cambridge University Press:  24 August 2021

Theresa Lakner*
Affiliation:
Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Mandy Cuevas
Affiliation:
Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Marie-Luise Polk
Affiliation:
Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Katja Petrowski
Affiliation:
Department of Medical Psychology and Medical Sociology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany Wissenschaftlicher Arbeitskreis der DRF Stiftung Luftrettung Gemeinnützige AG, Filderstadt, Germany
Mark Frank
Affiliation:
Wissenschaftlicher Arbeitskreis der DRF Stiftung Luftrettung Gemeinnützige AG, Filderstadt, Germany Department of Emergency Medicine, Municipal Hospital Dresden, Germany German Air Rescue gAG (DRF Stiftung Luftrettung gAG), Filderstadt, Germany
*
Correspondence: Theresa Lakner Department of Otorhinolaryngology Fetscherstraße 74, 01307 Dresden, Germany E-mail: [email protected]

Abstract

Introduction:

Anaphylactic reactions can lead to a life-threatening situation. In the event of anaphylaxis, rapid and targeted emergency treatment is indicated.

Study Objective:

The study sought to determine the emergency therapy administered for anaphylaxis in children and adults. Focus was placed on therapy with adrenaline. In addition, the study aimed to investigate demographic data, triggers, and hospitalization rates of the different severities of anaphylaxis.

Methods:

A retrospective analysis of anaphylactic reactions was conducted using data from prehospital emergency missions performed by the Air Rescue Dresden/Germany from 2008 through 2015 using the standardized application protocol EPRO-5.0 (MIND 3) anonymized. Data from 152 adults and 29 children were evaluated, focusing especially on the acute treatment as well as demographic information, triggers, and symptoms of anaphylactic reactions.

Results:

In total, 152 adults (73 female, 79 male) from 18 to 87 years (mean 50.5 years) and 29 children (9 female, 20 male) from 1 to 16 years (mean 7.5 years) with anaphylactic reactions were analyzed. The most common trigger for severe anaphylactic reactions (Grade II-IV; classification modified according to Ring and Messmer) was food in children (33%) and insect venom in adults (59%). The data show that 19% of adults with Grade II-IV anaphylactic reactions (classification modified according to Ring and Messmer) received adrenaline. Regarding children, the appliance of adrenaline was only administered in seven percent of the cases of Grade II-IV anaphylactic reactions. Adults with Grade II or higher anaphylactic reactions were hospitalized in 92%. Three percent refused hospitalization and five percent were not transferred to hospital. One-hundred percent of the children with Grade II-IV anaphylaxis were hospitalized.

Conclusions:

Analysis of data from the Air Rescue Dresden/Germany shows that despite existing recommendations, only 19% of adults with severe anaphylaxis received adrenaline. Among children, only in seven percent was a treatment with adrenaline performed.

On the other hand, all patients survived the acute emergency treatment without apparent adverse outcomes. Thus, further studies are needed to determine the proper use of adrenaline in anaphylactic reactions.

Type
Original Research
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the World Association for Disaster and Emergency Medicine

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Johansson, SGO, Bieber, T, Dahl, R, et al. Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004;113(5):832836.CrossRefGoogle ScholarPubMed
Ring, J, Grosber, M, Möhrenschlager, M, Brockow, K.Anaphylaxis: Acute Treatment and Management.” In: Ring J, (ed). Chemical Immunology and Allergy. Basel, Switzerland: KARGER; 2010.Google Scholar
Simons, FER, Ardusso, LRF, Bilò, MB, et al. World allergy organization guidelines for the assessment and management of anaphylaxis. World Allergy Organ J. 2011;4(2):1337.CrossRefGoogle ScholarPubMed
Ring, J, Beyer, K, Biedermann, T, et al. Leitlinie zu Akuttherapie und Management der Anaphylaxie - Update 2021: S2k-Leitlinie der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI), des Ärzteverbands Deutscher Allergologen (AeDA), der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA), der Deutschen Akademie für Allergologie und Umweltmedizin (DAAU), des Berufsverbands der Kinder- und Jugendärzte (BVKJ), der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI), der Deutschen Dermatologischen Gesellschaft (DDG), der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI), der Schweizerischen Gesellschaft für Allergologie und Immunologie (SGAI), der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin (DGAI), der Deutschen Gesellschaft für Pharmakologie (DGP), der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin (DGP), der Patientenorganisation Deutscher Allergie- und Asthmabund (DAAB) und der Arbeitsgemeinschaft Anaphylaxie - Training and Education (AGATE). Allergo J. 2021;30(1):2049.CrossRefGoogle Scholar
Ring, J, Messmer, K. Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet. 1977;1(8009):466469.CrossRefGoogle ScholarPubMed
Decker, WW, Campbell, RL, Manivannan, V, et al. The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project. J Allergy Clin Immunol. 2008;122(6):11611165.CrossRefGoogle ScholarPubMed
Poulos, LM, Waters, A-M, Correll, PK, Loblay, RH, Marks, GB. Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993-1994 to 2004-2005. J Allergy Clin Immunol. 2007;120(4):878884.CrossRefGoogle ScholarPubMed
Sheikh, A, Hippisley-Cox, J, Newton, J, Fenty, J. Trends in national incidence, lifetime prevalence and adrenaline prescribing for anaphylaxis in England. J R Soc Med. 2008;101(3):139143.CrossRefGoogle ScholarPubMed
Moneret-Vautrin, DA, Morisset, M, Flabbee, J, Beaudouin, E, Kanny, G. Epidemiology of life-threatening and lethal anaphylaxis: a review. Allergy. 2005;60(4):443451.CrossRefGoogle ScholarPubMed
Worm, M, Eckermann, O, Dölle, S, et al. Triggers and treatment of anaphylaxis. Deutsches Aerzteblatt Online. 2014. https://www.aerzteblatt.de/10.3238/arztebl.2014.0367. Accessed February 3, 2021.Google Scholar
Vincent, J-L, De Backer, D. Circulatory shock. N Engl J Med. 2014;370(6):583.Google ScholarPubMed
Walther, A, Böttiger, BW. Anaphylaktoide Reaktionen in der Prähospitalphase. Der Internist. 2004;45(3):296304.CrossRefGoogle Scholar
Einsatzprotokoll EPRO 5.0 (MIND 3). http://shop.thieme-dokuform.de/25x-Einsatzprotokoll-EPRO-5.0-(MIND3). Accessed February 3, 2021.Google Scholar
DIVI. https://www.divi.de/. Accessed February 3, 2021.Google Scholar
Worm, M, Edenharter, G, Ruëff, F, et al. Symptom profile and risk factors of anaphylaxis in Central Europe. Allergy. 2012:67(5):691698.CrossRefGoogle ScholarPubMed
Anaphylaxie Register. https://www.anaphylaxie.net/de. Accessed March 1, 2021.Google Scholar
Dhami, S, Panesar, SS, Roberts, G, et al. Management of anaphylaxis: a systematic review. Allergy. 2014;69(2):168175.CrossRefGoogle ScholarPubMed
Huang, F, Chawla, K, Järvinen, KM, Nowak-Węgrzyn, A. Anaphylaxis in a New York City pediatric emergency department: triggers, treatments, and outcomes. J Allergy Clin Immunol. 2012;129(1):162168.e1-3.CrossRefGoogle Scholar
Pumphrey, RSH, Gowland, MH. Further fatal allergic reactions to food in the United Kingdom, 1999-2006. J Allergy Clin Immunol. 2007;119(4):10181019.CrossRefGoogle ScholarPubMed
Clark, S, Bock, SA, Gaeta, TJ, Brenner, BE, Cydulka, RK, Camargo, CA. Multicenter study of emergency department visits for food allergies. J Allergy Clin Immunol. 2004;113(2):347352.CrossRefGoogle ScholarPubMed
Helbling, A, Müller, U, Hausmann, O. Anaphylaxie – Realität der Akuttherapie und präventiver Maßnahmen. Analyse von 54 Patienten eines spezialisierten Stadtspitals. AL. 2009;32(09):358364.CrossRefGoogle Scholar
Nowak, R, Farrar, JR, Brenner, BE, et al. Customizing anaphylaxis guidelines for emergency medicine. J Emerg Med. 2013;45(2):299306.CrossRefGoogle ScholarPubMed
Simons, FE, Gu, X, Simons, KJ. Epinephrine absorption in adults: intramuscular versus subcutaneous injection. J Allergy Clin Immunol. 2001;108(5):871873.CrossRefGoogle ScholarPubMed
Simons, FER, Ardusso, LRF, Dimov, V, et al. World Allergy Organization Anaphylaxis Guidelines: 2013 update of the evidence base. Int Arch Allergy Immunol. 2013;162(3):193204.CrossRefGoogle ScholarPubMed
Rudders, SA, Banerji, A. An update on self-injectable epinephrine. Curr Opin Allergy Clin Immunol. 2013;13(4):432437.CrossRefGoogle ScholarPubMed