Endovascular procedures in emergencies like the implantation of tubes for a life support system are increasing. Guidewires are the essential basis for the regularly used Seldinger Technique. We present a novel concept that may further optimize the safety and efficacy of guidewire handling and navigation during endovascular procedures.

Using specifically designed luminescent particles, a novel, clinical-grade coating protocol was created to develop a new luminescent guidewire. Different prototypes were designed and tested for their luminescent capacity following a short exposure to any light-source. Chemical-analysis, hemocompatibility, hemolysis and cytotoxicity testing of the new guidewire was performed. The usability of the new prototype was compared to regular guidewires by application into needles, catheters and tubes which are used during percutaneous procedures.

The engineered guidewires demonstrated a luminescent capacity of at least 20 minutes after less than ten seconds of exposure to a light source. Chemical analysis, cytotoxicity, hemolysis, and hemocompatibility indicated a biocompatibility profile of the guidewire. Good usability, safe and rapid handling was demonstrated when simulating endovascular procedures. Under dimmed-light conditions, the luminescent guidewire demonstrated substantially enhanced visibility when compared to the standard-of-care.

We present a new, luminescent guidewire that may enhance the safety and efficacy of endovascular procedures, especially where light conditions are suboptimal or for emergency situations when procedures have to be as fast and efficient as possible.