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The Extracorporeal Joining of Donor (Pig) Spleen (EJDS) for the Treatment of Patients with the Complications of Shockogenic Trauma

Published online by Cambridge University Press:  28 June 2012

Michael V. Grinev ,
M. N. Tarelkina ,
G. M. Frolov  and
Yu. N. Tsibin
Michael V. Grinev
Affiliation:
I. I. Dzhanelidze Institute of the First Aid Research Center, Leningrad, USSR
M. N. Tarelkina
Affiliation:
I. I. Dzhanelidze Institute of the First Aid Research Center, Leningrad, USSR
G. M. Frolov
Affiliation:
I. I. Dzhanelidze Institute of the First Aid Research Center, Leningrad, USSR
Yu. N. Tsibin
Affiliation:
I. I. Dzhanelidze Institute of the First Aid Research Center, Leningrad, USSR
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Abstract

Introduction:

A principal cause of death following presumed recovery from an episode of shock is the development of shockogenic trauma [post-resuscitation syndrome]. The causes of this complication remain unclear and its various treatments continue to be controversial.

Hypothesis:

The use of perfusion of the blood of patients suffering shockogenic trauma through a donor pig spleen mill decrease the mortality from the complications of this process.

Methods:

Freshly harvested pig spleens were adjoined to the venous circulation of patients suffering severe shockogenic trauma and the patient's blood perfused through them for periods of 30-60 minutes. The mortality rates of similar patients treated in this manner were compared with those not treated. Blood analyses included measures of the functions of the renal, immune, and coagulation systems.

Results:

The experience with 212 Extracorporeal Joinings of Donor (pig) Spleens (EJDS) by means of a veno-venous shunt for the treatment of 86 patients with severe shock trauma and its complications is reported. The clinical effects consisted of decreasing signs of intoxication, namely reduction in fever and in the severity of associated encephalopathy. Extracoporeal joinings on donor (pig) spleens (EJDS) was followed by a decline in the concentration of “middle molecules,” fibrinogen levels, leucocyte intoxication index, and the number of circulating immune complexes at different times following complexion of the procedure. The number of blood cells remained constant. On the following day, there occurred an increase in the number of thrombocytes. In addition, there was a decline in the quantity of circulating particles in the plasma. The level of plasma creatinine remained constant.

Conclusions:

Extracoporeal circulation through donor (pig) spleens (EJDS) has an important influence on that part of the immune system that performs the functions of phagocytosis, and also increases the levels of chemokinetic and chemotaxc reactions.

Type
Original Research
Information
Prehospital and Disaster Medicine , Volume 7 , Issue 1 , March 1992 , pp. 41 - 44
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1992

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