Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-23T10:40:38.371Z Has data issue: false hasContentIssue false
  • English
  • Français

Brain Resuscitation Clinical Trial (BRCT)

Published online by Cambridge University Press:  17 February 2017

A. Mullie ,
P. Lust ,
J. Penninckx ,
L. Vanhove ,
K. Vandevelde ,
G. Vanhoonacker ,
M. Janssens ,
M. Krier  and
J.L. Demeere
A. Mullie
Affiliation:
Department of Critical Care Medicine, St. Jans Hospital, Brugge, Belgium; and the BRCT Steering Committee, Resuscitation Research Center, University of Pittsburgh, USA
P. Lust
Affiliation:
Department of Critical Care Medicine, St. Jans Hospital, Brugge, Belgium; and the BRCT Steering Committee, Resuscitation Research Center, University of Pittsburgh, USA
J. Penninckx
Affiliation:
Department of Critical Care Medicine, St. Jans Hospital, Brugge, Belgium; and the BRCT Steering Committee, Resuscitation Research Center, University of Pittsburgh, USA
L. Vanhove
Affiliation:
Department of Critical Care Medicine, St. Jans Hospital, Brugge, Belgium; and the BRCT Steering Committee, Resuscitation Research Center, University of Pittsburgh, USA
K. Vandevelde
Affiliation:
Department of Critical Care Medicine, St. Jans Hospital, Brugge, Belgium; and the BRCT Steering Committee, Resuscitation Research Center, University of Pittsburgh, USA
G. Vanhoonacker
Affiliation:
Department of Critical Care Medicine, St. Jans Hospital, Brugge, Belgium; and the BRCT Steering Committee, Resuscitation Research Center, University of Pittsburgh, USA
M. Janssens
Affiliation:
Department of Critical Care Medicine, St. Jans Hospital, Brugge, Belgium; and the BRCT Steering Committee, Resuscitation Research Center, University of Pittsburgh, USA
M. Krier
Affiliation:
Department of Critical Care Medicine, St. Jans Hospital, Brugge, Belgium; and the BRCT Steering Committee, Resuscitation Research Center, University of Pittsburgh, USA
J.L. Demeere
Affiliation:
Department of Critical Care Medicine, St. Jans Hospital, Brugge, Belgium; and the BRCT Steering Committee, Resuscitation Research Center, University of Pittsburgh, USA
Get access Rights & Permissions [Opens in a new window]

Extract

The Critical Care Medicine department, St. Jans hospital, Brugge, has a prehospital emergency medicine service (EMS) staffed by experienced intensive care specialists. We have been involved in clinical research for the improvement of cerebral outcome after circulatory arrest (CA) and cardiopulmonary resuscitation (CPR) since 1977. In 1982, 250 patients in CA were resuscitated from an area of about 150,000 people. There were 70 short-term survivals, 30 longtime survivals. Although the success rate of CPR is highly influenced by important EMS related factors, including response time, a substantial proportion of hearts are restarted also after prolonged CA, but the patients die later in brain failure. There is evidence that the brain is not only damaged by the CA itself, but that lesions after restoration of spontaneous circulation (ROSC) progress and are amenable to therapy. We can illustrate the progressivity of brain lesions by two phenomena: 1) Animal experiments in other centers (P. Safar, J. Michenfelder) and our research at Janssen Pharmaceutics, Beerse, Belgium. Cerebral venous blood was sampled from the sagittal sinus after a prolonged CA (10 min); cerebral venous PO2 of 40-60 mmHg before CA, rose to 80-100 mmHg immediately after ROSC and about 1-2 h after ROSC decreased to 20-30 mmHg — indicating progressive failure of oxygen transport. 2) Cerebrospinal fluid (CSF) enzyme activity was studied after CA in humans. We correlated final neurological outcome with the early appearance (at 2k h) of lytic enzymes in the CSF. In some patients who later recover neurologically only partially, CSF enzymes are still low at 2k h, as if the cells are still viable at this stage.

Type
Section Two—Clinical Topics
Information
Prehospital and Disaster Medicine , Volume 1 , Issue 3 , Fall 1985 , pp. 238 - 241
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Safar, P. Cardiopulmonary cerebral resuscitation recommendations and patient trials protocols. In, Safar, P (ed). Advances in Cardiopulmonary Resuscitation. New York: Springer Verlag, 1977:195–207.CrossRefGoogle Scholar
2 Breivik, H, Safar, P, Sands, P, et al. Clinical feasibility trials of barbiturate therapy after cardiac arrest. Crit Care Med 1978; 6:228–244.Google Scholar
3 Mullie, A, Abramson, N, Safar, P, et al. Clinical pilot studies of thiopental loading after cardiac arrest. Crit Care Med 1981; 9:184 (abstract).CrossRefGoogle Scholar
4 Abramson, NS, Safar, P, Detre, K, et al. An international collaborative clinical study mechanism for resuscitation research. Resuscitation 1982; 10:141–147.Google Scholar
5 Kelsey, SF, Abramson, NS, Detre, KM, et al. Randomized clinical study of cardiopulmonary cerebral resuscitation: design, methods and patient characteristics. Am J Emerg Med, in press January 1986.Google Scholar
6 Abramson, NS, Safar, P, Detre, K, et al. Neurologic outcome of survivors of cardiac arrest. Anesthesiology 1982; 57(suppl):A92 (synopsis abstract). Also Circulation 1982} 66(suppl II):II-250 (abstract). Also Crit Care Med 1982; 10.215 (abstract).Google Scholar
7 Abramson, N, Safar, P, Detre, K, et al. , and the Brain Resuscitation Clinical Trial I Study Group. Randomized clinical study of cardiopulmonary-cerebral resuscitation: thiopental loading in comatose cardiac arrest survivors. Crit Care Med 1984; 12:227 (abstract). Manuscript submitted 1985.Google Scholar
8 Abramson, NS, Meisel, A, Safar, P. Informed consent in resuscitation research. JAMA 1981; 246:2828–2830.Google Scholar
9 Abramson, N, Meisel, A, Safar, P. Deferred consent: a new approach to resuscitation research. JAMA in press 1985.Google Scholar