On 12 January 2010, the fate of Haiti and its people shifted with the ground beneath them as the strongest earthquake in 200 years, and a series of powerful aftershocks demolished the capital and multiple areas throughout the southern coast in thirty seconds, leaving some 220,000 people dead, and 300,000 persons injured. On 27 February 2010, at 03:35 hours local time, an earthquake of magnitude 8.8 struck Chile. As a consequence, the tsunami generated affected a coastal strip of more than 500 kilometers. Approximately 1.5 million people were affected and thousands lost their homes and livelihoods. The emergency health response of the International Red Cross Movement to both disasters was immediate, powerful and dynamic. The IFRC deployed seven emergency response units (ERU) to Haiti: one 150-bed referral hospital, one Rapid Deployment Emergency Hospital, and five basic health care units. One surgical hospital and two Basic Health Care Units were deployed to Chile. The ERU system of the IFRC is a flexible and dynamic tool for emergency health response in shifting and challenging environments. Evaluations show that the system performs well during urban and rural disasters. Despite a very different baseline in the two contexts, the ERU system of IFRC can adapt to the local needs. As panorama of pathology in the aftermath of an earthquake changes, the ERU system adapts and continues supporting the local health care system in its recovery.