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X-ray diffraction data of tibolone Δ4 isomer (isotibolone)

Published online by Cambridge University Press:  29 February 2012

Selma Gutierrez Antonio ,
Fabio Furlan Ferreira ,
Gabriel Lima Barros Araujo ,
Jivaldo do Rosario Matos  and
Carlos de Oliveira Paiva-Santos
Selma Gutierrez Antonio*
Affiliation:
Departamento de Físico Química, Instituto de Química, Universidade Estadual Paulista, Caixa Postal 355, 14801-970 Araraquara, SP, Brazil
Fabio Furlan Ferreira
Affiliation:
Laboratório Nacional de Luz Síncrotron, Caixa Postal 6192, 13083-970 Campinas, SP, Brazil
Gabriel Lima Barros Araujo
Affiliation:
Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil
Jivaldo do Rosario Matos
Affiliation:
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes, 748, Sala 0801, 05508-900 São Paulo, SP, Brazil
Carlos de Oliveira Paiva-Santos
Affiliation:
Departamento de Físico Química, Instituto de Química, Universidade Estadual Paulista, Caixa Postal 355, 14801-970 Araraquara, SP, Brazil
*
a)Author to whom correspondence should be addressed. Electronic mail: [email protected]
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Abstract

Tibolone is used for hormone reposition of postmenopause women and isotibolone is considered the major degradation product of tibolone. Isotibolone can also be present in tibolone API raw materials due to some inadequate synthesis. Its presence is then necessary to be identified and quantified in the quality control of both API and drug products. In this work we present the indexing of an isotibolone X-ray diffraction pattern measured with synchrotron light (λ=1.2407 Å) in the transmission mode. The characterization of the isotibolone sample by IR spectroscopy, elemental analysis, and thermal analysis are also presented. The isotibolone crystallographic data are a=6.8066 Å, b=20.7350 Å, c=6.4489 Å, β=76.428°, V=884.75 Å3, and space group P21, ρo=1.187 g cm−3, Z=2.

Keywords

isotibolonehormoneindexingX-ray powder diffractionsynchrotron radiation
Type
New Diffraction Data
Information
Powder Diffraction , Volume 24 , Issue 4 , December 2009 , pp. 337 - 342
Copyright
Copyright © Cambridge University Press 2009

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