Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-04T21:06:54.046Z Has data issue: false hasContentIssue false
  • English
  • Français

Characterization by X-ray powder diffraction of alpha lipoic acid

Published online by Cambridge University Press:  28 November 2016

Jose H. Quintana Mendoza ,
R. A. Toro ,
Laura A. Blanco  and
J. A. Henao
Jose H. Quintana Mendoza*
Affiliation:
Grupo de Investigación en Química Estructural (GIQUE), Escuela de Química, Facultad de Ciencias, Universidad Industrial de Santander, A.A. 678, Carrera 27, Calle 9 Ciudadela Universitaria, Bucaramanga, Colombia
R. A. Toro
Affiliation:
Grupo de Investigación en Química Estructural (GIQUE), Escuela de Química, Facultad de Ciencias, Universidad Industrial de Santander, A.A. 678, Carrera 27, Calle 9 Ciudadela Universitaria, Bucaramanga, Colombia
Laura A. Blanco
Affiliation:
Grupo de Investigación en Química Estructural (GIQUE), Escuela de Química, Facultad de Ciencias, Universidad Industrial de Santander, A.A. 678, Carrera 27, Calle 9 Ciudadela Universitaria, Bucaramanga, Colombia
J. A. Henao
Affiliation:
Grupo de Investigación en Química Estructural (GIQUE), Escuela de Química, Facultad de Ciencias, Universidad Industrial de Santander, A.A. 678, Carrera 27, Calle 9 Ciudadela Universitaria, Bucaramanga, Colombia
*
a)Author to whom correspondence should be addressed. Electronic mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Alpha lipoic acid (ALA) C8H14O2S2 is a naturally occurring compound that is synthesized in small amounts by plants and animals, including humans. ALA is covalently bound to specific proteins, which function as cofactors for several important mitochondrial enzyme complexes and studies suggest that they might help with type 2 diabetes. In the Cambridge Structural Database, there are four entries related to this compound: two for lipoic acid and two for complexes. In the Powder Diffraction File-4, two experimental unindexed patterns are reported. The material crystallizes in a monoclinic crystal system, space group P21/a and cell parameters a = 9.237 (1) Å, b = 9.960 (1) Å, c = 11.787 (2) Å, β = 109.13 (1)°, and V = 1024.6 (2) Å3.

Keywords

alpha lipoic acidcharacterizationX-ray powder diffraction
Type
New Diffraction Data
Information
Powder Diffraction , Volume 32 , Issue 1 , March 2017 , pp. 35 - 39
Check for updates
Copyright
Copyright © International Centre for Diffraction Data 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allen, F. H. (2002). “The Cambridge Structural Database: a quarter of a million crystal structures and rising,” Acta Crystallogr. B: Struct. Sci. 58, 380–388.CrossRefGoogle ScholarPubMed
Boultif, A. and Loüer, D. (2014). “Some further considerations in powder diffraction pattern indexing with the dichotomy method,” Powder Diffr. 29(S2), S7–S12.Google Scholar
Carreau, J. P. (1979). “Biosynthesis of lipoic acid via unsaturated fatty acids,” Methods Enzymol. 62, 152–158.Google Scholar
de Wolff, P. M. (1968). “A simplified criterion for the reliability of a powder pattern indexing,” J. Appl. Crystallogr. 1, 108–113.Google Scholar
Dong, C. (1999). “PowderX: windows-95-based program for poder X-ray diffraction data processing,” J. Appl. Crystallogr. 32, 838–838.Google Scholar
ICDD (2012). “PDF-4/organics 2012 (database),” edited by Kabekkodu, S. (International Centre for Diffraction Data, Newtown Square, PA, USA).Google Scholar
Laugier, J. and Bochu, B. (2002). CHEKCELL. “LMGP-Suite Suite of Programs for the interpretation of X-ray. Experiments,” ENSP/Laboratoire des Matériaux et du Génie Physique, BP 46. 38042 Saint Martin d'Hères, France. http://www.inpg.fr/LMGP and http://www.ccp14.ac.uk/tutorial/lmgp/.Google Scholar
Mighell, A. D., Hubbard, C. R., and Stalick, J. K. (1981). NBS* AIDS80: a Fortran Program for Crystalographic Data Evaluation. USA: National Bureau Standards, Technical Note 1141. (NBS*AIDS83 is a newer versión ofNBS*AIDS80).CrossRefGoogle Scholar
Rachinger, W. A. (1948). “A correction for the α 1 α 2 doublet in the measurement of widths of X-ray diffraction lines,” J. Sci. Instrum. 25, 254.CrossRefGoogle Scholar
Reed, L. J. (2001). “A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes,” J. Biol. Chem. 276(42), 38329–38336.Google Scholar
Rodriguez-Carvajal, J. (1990). “FULLPROF: a program for Rietveld refinement and pattern matching analysis,” in Abstracts of the Satellite Meeting on Powder Diffraction of the XV Congress of the IUCr, Toulouse, France, p. 127.Google Scholar
Saviztky, A. and Golay, M. J. (1964). “Smoothing and differentiation of data by simplified least squares procedures,” Anal. Chem. 36, 1627–1639.Google Scholar
Smith, G. S. and Snyder, R. L. (1979). “FN: a criterion for rating powder dif-fraction patterns and evaluating the reliability of powder-pattern index-ing,” J. Appl. Crystallogr. 12, 60–65.Google Scholar
Sonneveld, E. J. and Visser, J. W. (1975). “Automatic collection of powder diffraction data from photographs,” J. Appl. Crystallogr. 8, 1–7.Google Scholar
Sweetman, S. C. (ed.) (2009). Martindale: the Complete Drug Reference (Pharmaceutical Press, London), 36th ed., p. 1120.Google Scholar
Supplementary material: File

Quintana Mendoza supplementary material S1

Quintana Mendoza supplementary material

Download Quintana Mendoza supplementary material S1(File)
File 70.7 KB
Supplementary material: File

Quintana Mendoza supplementary material S2

Quintana Mendoza supplementary material

Download Quintana Mendoza supplementary material S2(File)
File 15.1 KB