Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-23T23:50:18.025Z Has data issue: false hasContentIssue false
  • English
  • Français

Identification of elite germplasm of medicinally important Andrographis paniculata (Burm. f.) Nees with high content of four active diterpenoids in aerial parts from wild populations of eastern India

Published online by Cambridge University Press:  06 December 2021

Bibhuti Bhusan Champati ,
Bhuban Mohan Padhiari ,
Asit Ray ,
Sudipta Jena ,
Ambika Sahoo ,
Tarun Halder ,
Biswajit Ghosh ,
Basudeba Kar ,
Pratap Chandra Panda  and
Sanghamitra Nayak Open the ORCID record for Sanghamitra Nayak [Opens in a new window]
Bibhuti Bhusan Champati
Affiliation:
Center for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar, Odisha, India
Bhuban Mohan Padhiari
Affiliation:
Center for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar, Odisha, India
Asit Ray
Affiliation:
Center for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar, Odisha, India
Sudipta Jena
Affiliation:
Center for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar, Odisha, India
Ambika Sahoo
Affiliation:
Center for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar, Odisha, India
Tarun Halder
Affiliation:
Ramakrishna Mission Vivekananda Centenary College, Rahara, Kolkata, West Bengal, India
Biswajit Ghosh
Affiliation:
Ramakrishna Mission Vivekananda Centenary College, Rahara, Kolkata, West Bengal, India
Basudeba Kar
Affiliation:
Center for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar, Odisha, India
Pratap Chandra Panda
Affiliation:
Center for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar, Odisha, India
Sanghamitra Nayak*
Affiliation:
Center for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar, Odisha, India
*
Author for correspondence: Sanghamitra Nayak, E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Andrographis paniculata is an Indian medicinal plant with tremendous therapeutic values due to the presence of active diterpenoids in its aerial parts. However, high domestic and export demand has led to overexploitation of wild populations of this species. With a view to bringing A. paniculata into cultivation and to reduce the pressure on wild populations, the present study was undertaken to identify elite germplasm from different locations of eastern India by analysing intraspecific variation in the content of four major active diterpenoids. A total of 166 wild accessions of A. paniculata analysed through high-performance liquid chromatography (HPLC) revealed remarkable variation in the sum of four active diterpenoids in the aerial parts, ranging from 0.41 to 8.55% on a dry weight basis. Three elite accessions (AP-6, AP-8, AP-46) having respectively 8.02, 8.36 & 8.55% of the sum of four major active diterpenoids were identified. These germplasm could be used for commercial cultivation and genetic improvement of A. paniculata.

Keywords

Active diterpenoidsAndrographis paniculataelite selectiongermplasm evaluation
Type
Short Communication
Information
Plant Genetic Resources , Volume 19 , Issue 6 , December 2021 , pp. 545 - 548
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of NIAB

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Akbar, A, Kuanar, A, Patnaik, J, Mishra, A and Nayak, S (2018) Application of artificial neural network modeling for optimization and prediction of essential oil yield in turmeric (Curcuma longa L.). Computers and Electronics in Agriculture 148, 160–178.CrossRefGoogle Scholar
Basak, UC, Dash, D and Mahapatra, AK (2012) Estimation of colchicine in tubers of Gloriosa superba L. Originated from different agroclimatic zones of Odisha, India. International Journal of Pharmacognosy and Phytochemical Research 4, 157–161.Google Scholar
Bhan, MK, Dhar, AK, Khan, S, Lattoo, SK, Gupta, KK and Choudhary, DK (2006) Screening and optimization of Andrographis paniculata (Burm. f.) Nees for total andrographolide content, yield and its components. Scientia Horticulturae 107, 386–391.CrossRefGoogle Scholar
Chao, WW and Lin, BF (2010) Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chinese Medicine 5, 1–15.CrossRefGoogle Scholar
Dai, Y, Chen, S, Chai, L, Zhao, J, Wang, Y and Wang, Y (2019) Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide. Critical Reviews in Food Science and Nutrition 59, S17–S29.CrossRefGoogle ScholarPubMed
Gowthami, R, Sharma, N, Pandey, R and Agrawal, A (2021) Status and consolidated list of threatened medicinal plants of India. Genetic Resources and Crop Evolution 68, 2235–2263.CrossRefGoogle ScholarPubMed
International Conference on Harmonization (2005) ICH Q2 (R1): Validation of Analytical Procedures: Text and Methodology. Geneva: ICH Secretariat.Google Scholar
Kamdem, RE, Sang, S and Ho, CT (2002) Mechanism of the superoxide scavenging activity of neoandrographolide-a natural product from Andrographis paniculata Nees. Journal of Agricultural and Food Chemistry 50, 4662–4665.CrossRefGoogle Scholar
Kataky, A and Handique, PJ (2010) A brief overview on Andrographis paniculata (Burm. f) Nees., a high valued medicinal plant: boon over synthetic drugs. Asian Journal of Science and Technology 6, 113–118.Google Scholar
Kumar, RA, Sridevi, K, Kumar, NV, Nanduri, S and Rajagopal, S (2004) Anticancer and immunostimulatory compounds from Andrographis paniculata. Journal of Ethnopharmacology 92, 291–295.CrossRefGoogle ScholarPubMed
Mishra, S, Tiwari, SK, Kakkar, A and Pandey, AK (2010) Chemoprofiling of Andrographis paniculata (kalmegh) for its andrographolide content in Madhya Pradesh, India. International Journal of Pharma and Bio Sciences 1, 1–5.Google Scholar
Pandey, A, Gulati, S, Gupta, A and Tripathi, Y (2019) Variation in andrographolide content among different accessions of Andrographis paniculata. The Pharma Innovation Journal 8, 140–144.Google Scholar
Pholphana, N, Rangkadilok, N, Saehun, J, Ritruechai, S and Satayavivad, J (2013) Changes in the contents of four active diterpenoids at different growth stages in Andrographis paniculata (Burm. f.) Nees (Chuanxinlian). Chinese Medicine 8, 1–12.CrossRefGoogle Scholar
Prathanturarug, S, Soonthornchareonnon, N, Chuakul, W and Saralamp, P (2007) Variation in growth and diterpene lactones among field-cultivated Andrographis paniculata. Journal of Natural Medicines 61, 159–163.CrossRefGoogle Scholar
Rafi, M, Devi, AF, Syafitri, UD, Heryanto, R, Suparto, IH, Amran, MB and Lim, LW (2020) Classification of Andrographis paniculata extracts by solvent extraction using HPLC fingerprint and chemometric analysis. BMC Research Notes 13, 1–6.CrossRefGoogle ScholarPubMed
Raina, AR, Sivaraj, N and Kumar, A (2016) Chemical diversity among Andrographis paniculata Nees (Kalmegh) and assessing climate suitable regions for elite germplasm distribution in India. Medicinal Plants 8, 294–302.Google Scholar
Rajagopal, S, Kumar, RA, Deevi, DS, Satyanarayana, C and Rajagopalan, R (2003) Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. Journal of Experimental Therapeutics and Oncology 3, 147–158.CrossRefGoogle ScholarPubMed
Roy, DN, Mandal, S, Sen, G, Mukhopadhyay, S and Biswas, T (2010) 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. British Journal of Pharmacology 160, 1823–1843.CrossRefGoogle ScholarPubMed
USP (2012) United States Pharmacopeial 35-national formulas 30. In United States Pharmacopeial Convention. Rockville, MD: Rockville, pp. 1183–1187.Google Scholar
Yang, L, Wen, KS, Ruan, X, Zhao, YX, Wei, F and Wang, Q (2018) Response of plant secondary metabolites to environmental factors. Molecules 23, 762.CrossRefGoogle ScholarPubMed
Zhang, C, Kuroyangi, M and Tan, BK (1998) Cardiovascular activity of 14-deoxy-11, 12–didehydroandrographolide in the anaesthetised rat and isolated right atria. Pharmacological Research 38, 413–417.CrossRefGoogle ScholarPubMed
Supplementary material: File

Champati et al. supplementary material

Champati et al. supplementary material

Download Champati et al. supplementary material(File)
File 69.2 KB