When we consider closely any highly integrated vital process, like embryonic development, or animal behavior of the end-subserving or purposive type, we are inevitably impressed with the importance of those special controlling factors, collectively termed “regulative,” which appear chiefly responsible for the unified and finalistic character of the whole sequence of events. These factors are persistent in their influence although they may act intermittently. Without their presence the sequence would soon lose coördination and “run wild,” just as an automobile runs off the road unless occasional compensating touches are given to the steering wheel. They are the factors which give unity and direction to the total process. Generalizing, we may say that in any complex unified process, especially a synthetic one—where the progress is from less to greater complexity—integration seems always to imply or presuppose the operation of regulative factors having the character which we call directive. These keep the sequence of events to a definite course which in the living organism usually terminates in some outcome having special biological significance, or survival value.