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When Causal Specificity Does Not Matter (Much): Insights from HIV Treatment

Published online by Cambridge University Press:  01 January 2022

Abstract

Philosophers of biology generally agree that causal specificity tracks biological importance: more specific causes are more important. I argue that this correlation does not hold in much research aimed at biomedical intervention. Applying James Woodward’s analysis of causal specificity to the development and design of HIV treatments, I show that drugs that are less causally specific produce better therapeutic outcomes and are more highly valued. Thus, I conclude that the importance of biological causes does not track their specificity but instead varies depending on the biological practice we consider and the goals of that practice.

Type
Research Article
Copyright
Copyright © The Philosophy of Science Association

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Footnotes

I would like to thank Jim Woodward, Mike Dietrich, Ken Schaffner, and David Colaço as well as the audience at PSA 2018 for helpful comments on earlier drafts of this article.

References

DHHS (Department of Health and Human Services). 2014. “Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents.” DHHS, Washington, DC.Google Scholar
Griffiths, P., and Gray, R. D.. 2004. “The Developmental Systems Perspective: Organism-Environment Systems as Units of Selection.” In Phenotypic Integration: Studying the Ecology and Evolution of Complex Phenotypes, ed. Pigliucci, M. and Preston, K.. Oxford: Oxford University Press.Google Scholar
Griffiths, P., and Stotz, K.. 2013. Genetics and Philosophy: An Introduction. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Mehellou, Y., and Clercq, E. De. 2010. “Twenty-Six Years of Anti-HIV Drug Discovery.” Journal of Medicinal Chemistry 53 (2): 521–38..10.1021/jm900492gCrossRefGoogle ScholarPubMed
Oyama, S. 1985. The Ontogeny of Information: Developmental Systems and Evolution. Durham, NC: Duke University Press.Google Scholar
Schaffner, K. F. 2016. Behaving: What’s Genetic, What’s Not, and Why Should We Care? Oxford: Oxford University Press.CrossRefGoogle Scholar
Waters, C. K. 2007. “Causes That Make a Difference.” Journal of Philosophy 104 (11): 551–79..CrossRefGoogle Scholar
Wlodawer, A. 2002. “Rational Approach to AIDS Drug Design.” Annual Review of Medicine 53:595614.CrossRefGoogle ScholarPubMed
Woodward, J. 2003. Making Things Happen: A Theory of Causal Explanation. Oxford: Oxford University Press.Google Scholar
Woodward, J.. 2010. “Causation in Biology: Stability, Specificity, and the Choice of Levels of Explanation.” Biology and Philosophy 25 (3): 287318..CrossRefGoogle Scholar
Yin, P. D., Das, D., and Mitsuya, H.. 2006. “Overcoming HIV Drug Resistance through Rational Drug Design.” Cellular and Molecular Life Sciences 63 (15): 1706–24..10.1007/s00018-006-6009-7CrossRefGoogle ScholarPubMed