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Reduction, Explanation, and the Quests of Biological Research

Published online by Cambridge University Press:  01 April 2022

Joseph D. Robinson
Joseph D. Robinson*
Affiliation:
Department of Pharmacology, State University of New York, Upstate Medical Center
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Abstract

A major theme in biological research is the quest for mechanism, embodied in explanatory reductionism: the interpretation of phenomena through links to the entities and laws of more fundamental sciences. For example, the form of Starling's Law of the Heart, relating contractile force to heart volume, follows from the sliding-filament hypothesis of muscle contraction, a molecular concept. Although alternative mechanisms for muscle contraction and cardiac regulation could be deduced from biochemical principles, the formulation provides clear correspondence with the phenomena and a deeper understanding of cardiac function. Moreover, even if the reduction provides no better formulation of the phenomenon, of the macro-regularity, it is still prized as a nearer approach to physical reality, as a step toward realizing fundamental unities and codifying general principles, and as a door to new experimental opportunities.

Type
Research Article
Information
Philosophy of Science , Volume 53 , Issue 3 , September 1986 , pp. 333 - 353
Copyright
Copyright © The Philosophy of Science Association 1986

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Footnotes

†

I am indebted to Alex Rosenberg for stimulating my interest in this topic and to the referees for their provocative criticisms

References

Biedert, S.; Barry, W.H.; and Smith, T.W. (1979), “Inotropic Effects and Changes in Sodium and Calcium Contents Associated with Inhibition of Monovalent Cation Active Transport by Ouabain in Cultured Myocardial Cells”, Journal of General Physiology 74: 479–94.Google ScholarPubMed
Caplan, A. (1981), “Babies, Bathwater and Derivational Reduction”, in PSA 1978, Asquith, P.D. and Hacking, I. (eds.), East Lansing: Philosophy of Science Association.Google Scholar
Chalmers, A.F. (1982), What Is this Thing Called Science. Milton Keynes: Open University Press.Google Scholar
Clarke, M. (1984), “Two States of Attachment”, Nature 310: 275.CrossRefGoogle ScholarPubMed
Engelhardt, W.A., and Ljubimova, M.N. (1939), “Myosine and Adenosinetriphosphatase”, Nature 144:668.CrossRefGoogle Scholar
Frank, R.G., Jr, . (1980), Harvey and the Oxford Physiologists. Berkeley and Los Angeles: University of California Press.Google Scholar
Frank, S.T. (1973), “Aural Sign of Coronary-Artery Disease”, New England Journal of Medicine 289: 327–28.Google ScholarPubMed
Fulton, J.F., and Wilson, L. G. (1966), Selected Readings in the History of Physiology. Springfield, IL.: Charles C. Thomas.Google Scholar
Hall, T.S. (1969), History of General Physiology. Chicago: University of Chicago Press.Google Scholar
Harvey, W. (1970), Anatomical Studies on the Motion of the Heart. Translated by C. D. Leake. Springfield, IL.: Charles C. Thomas.Google Scholar
Hull, D.L. (1974), Philosophy of Biological Science. Engelwood Cliffs, NJ: Prentice-Hall.Google Scholar
Hull, D.L. (1982), “Philosophy and Biology”, in Contemporary Philosophy: A New Survey, Floistad, G. (ed.). The Hague: Martinus Nijhoff.Google Scholar
Huxley, A.F., and Niedergerke, R. (1954), “Structural Changes in Muscle during Contraction”, Nature 173: 971–72.Google ScholarPubMed
Huxley, H.E., and Hanson, J. (1954), “Changes in the Cross-Striation of Muscle During Contraction and Stretch and their Structural Interpretation”, Nature 173: 973–76.Google Scholar
Judson, H.F. (1979), The Eighth Day of Creation. New York: Simon and Schuster.Google Scholar
Meyer, K.H. (1929), “Über Feinbau, Festigkeit und Kontraktilität tierischer Gewebe”, Biochemische Zeitschrift 214: 253–81.Google Scholar
Nagel, E. (1979), The Structure of Science. Indianapolis: Hackett.Google Scholar
Ringer, S. (1883), “A Further Contribution Regarding the Influence and Different Constituents of the Blood on the Contraction of the Heart”, Journal of Physiology 4: 29–42.CrossRefGoogle ScholarPubMed
Robinson, J.D. (1984), “The Chemiosmotic Hypothesis of Energy Coupling and the Path of Scientific Opportunity”, Perspectives in Biology and Medicine. 27: 367–83.CrossRefGoogle ScholarPubMed
Schaffner, K.F. (1967), “Approaches to Reduction”, Philosophy of Science 34: 137–47.CrossRefGoogle Scholar
Squire, John (1981), The Structural Basis of Muscular Contraction. New York: Plenum Press.CrossRefGoogle Scholar
Starling, E.H. (1918), The Linacre Lecture on the Law of the Heart. London: Longmans Green.Google Scholar
Szent-Gyorgyi, A.G. (1955), “Structural and Functional Aspects of Myosin”, Advances in Enzymology 16: 313–60.Google ScholarPubMed
Watson, J.D. (1968), The Double Helix. New York: Athaneum.Google Scholar
Weber, E. (1846), Wagners Handworterbuch der Physiologie.Google Scholar
Wimsatt, W.C. (1976), “Reductive Explanation: A Functional Account”, Boston Studies in the Philosophy of Science XXXII, pp. 671–710.CrossRefGoogle Scholar