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The Role of Randomness in Darwinian Evolution

Published online by Cambridge University Press:  01 January 2022

Andreas Wagner
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Abstract

Historically, one of the most controversial aspects of Darwinian evolution has been the prominent role that randomness and random change play in it. Most biologists agree that mutations in DNA have random effects on fitness. However, fitness is a highly simplified scalar representation of an enormously complex phenotype. Challenges to Darwinian thinking have focused on such complex phenotypes. Whether mutations affect such complex phenotypes randomly is ill understood. Here I discuss three very different classes of well-studied molecular phenotypes in which mutations cause nonrandom changes, based on our current knowledge. What is more, this nonrandomness facilitates evolutionary adaptation. Thus, living beings may translate DNA change into nonrandom phenotypic change that facilitates Darwinian evolution.

Type
Research Article
Information
Philosophy of Science , Volume 79 , Issue 1 , January 2012 , pp. 95 - 119
Copyright
Copyright © The Philosophy of Science Association

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Footnotes

‡

I acknowledge support through Swiss National Science Foundation grants 315200-116814, 315200-119697, and 315230-129708, as well as through the YeastX project of SystemsX.ch.

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