According to the Journal of Pain and Palliative Care Pharmacology, 25–88% of all hospice patients, caregivers, and hospice staff will observe significant changes in a patient's behaviors. Some of the changes include picking at sheets or Depends, restlessness movements of the arms and legs, confusion, tight clutching at caregiver's hands, and twitching and jerking. These signs are usually categorized as terminal restlessness. Sometimes, the cause is a medical condition that can be treated.