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Delirium superimposed on dementia versus delirium in the absence of dementia: Phenomenological differences

Published online by Cambridge University Press:  26 November 2009

Soenke Boettger ,
Steven Passik  and
William Breitbart
Soenke Boettger
Affiliation:
Department of Psychiatry, Memorial Sloan Kettering Cancer Center, New York, New York
Steven Passik
Affiliation:
Department of Psychiatry, Memorial Sloan Kettering Cancer Center, New York, New York
William Breitbart*
Affiliation:
Department of Psychiatry, Memorial Sloan Kettering Cancer Center, New York, New York
*
Address correspondence and reprint requests to: William Breitbart, Memorial Sloan Kettering Cancer Center, Department of Psychiatry, 641 Lexington Avenue, New York, NY 10022. E-mail: [email protected]
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Abstract

Objective:

To examine differences in the phenomenological characteristics of delirium superimposed on dementia compared to those observed in delirious patients without dementia, based on the rating items of the Memorial Delirium Assessment Scale (MDAS).

Methods:

We conducted an analysis of a prospectively collected clinical delirium database utilized to record and monitor the care of delirious patients treated at Memorial Sloan-Kettering Cancer Center (MSKCC). Sociodemographic, medical variables, and MDAS total score and individual item ratings were analyzed in respect to differences between delirium in the demented (DD) versus delirium in the nondemented (ND).

Results:

We were able to examine data collected on 100 delirious patients: 82 ND patients and 18 DD patients. Patients in the DD group, compared to the ND group, had significantly greater levels of disturbance of consciousness and impairments in all cognitive domains (i.e., orientation, short term memory, concentration, organization of thought process). Severe symptoms were more common in the DD group compared to the ND group on all the MDAS cognitive items as well as in disturbance of consciousness. There were no significant differences between the DD and ND groups in terms of presence or severity of hallucinations, delusions, psychomotor behavior, and sleep–wake cycle disturbance.

Significance of results:

Delirium superimposed on dementia has phenomenological differences compared to delirium in the absence of dementia. There are no significant differences in the severity of hallucinations, delusions, psychomotor behavior, or sleep–wake cycle disturbances. However, level of disturbance in consciousness (arousal and awareness) and impairments in multiple cognitive domains are significantly more severe in patients with delirium superimposed on dementia.

Keywords

DeliriumDementiaPhenomenologyDelirium superimposed on dementia
Type
Original Articles
Information
Palliative & Supportive Care , Volume 7 , Issue 4 , December 2009 , pp. 495 - 500
Copyright
Copyright © Cambridge University Press 2009

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