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Unmet mental health needs in patients with advanced B-cell lymphomas

Published online by Cambridge University Press:  18 August 2021

Chrystal Marte Open the ORCID record for Chrystal Marte [Opens in a new window] ,
Login S. George ,
Sarah C. Rutherford ,
Daniel Jie Ouyang ,
Peter Martin ,
John P. Leonard  and
Kelly M. Trevino Open the ORCID record for Kelly M. Trevino [Opens in a new window]
Chrystal Marte
Affiliation:
Memorial Sloan Kettering Cancer Center, New York, NY
Login S. George
Affiliation:
Memorial Sloan Kettering Cancer Center, New York, NY
Sarah C. Rutherford
Affiliation:
Weill Cornell Medicine, New York, NY New York Presbyterian, New York, NY
Daniel Jie Ouyang
Affiliation:
SUNY Downstate Medical Center, New York, NY
Peter Martin
Affiliation:
Weill Cornell Medicine, New York, NY New York Presbyterian, New York, NY
John P. Leonard
Affiliation:
Weill Cornell Medicine, New York, NY New York Presbyterian, New York, NY
Kelly M. Trevino*
Affiliation:
Memorial Sloan Kettering Cancer Center, New York, NY
*
Author for correspondence: Chrystal Marte, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Avenue, New York, NY 10022, USA. E-mail: [email protected]
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Abstract

Context

Existing research on psychological distress and mental health service utilization has focused on common types of solid tumor cancers, leaving significant gaps in our understanding of patients experiencing rare forms of hematologic cancers.

Objective

To examine distress, quality of life, and mental health service utilization among patients with aggressive, refractory B-cell lymphomas.

Method

Patients (n = 26) with B-cell lymphomas that relapsed after first- or second-line treatment completed self-report measures of distress (Hospital Anxiety and Depression Scale) and quality of life (Short-Form Health Survey, SF-12). Patients also reported whether they had utilized mental health treatment since their cancer diagnosis.

Results

Approximately 42% (n = 11) of patients reported elevated levels of psychological distress. Of patients with elevated distress, only one quarter (27.2%; n = 3) received mental health treatment, while more than half did not receive mental health treatment (54.5%; n = 6), and 18.1% (n = 2) did not want treatment. Patients with elevated distress reported lower mental quality of life than patients without elevated distress [F (1, 25) = 15.32, p = 0.001].

Significance of the results

A significant proportion of patients with advanced, progressive, B-cell lymphomas may experience elevated levels of distress. Yet, few of these distressed patients receive mental health treatment. Findings highlight the need to better identify and address barriers to mental health service utilization among patients with B-cell lymphoma, including among distressed patients who decline treatment.

Keywords

B-cell lymphomaDistressMental health treatment utilizationQuality of life
Type
Original Article
Information
Palliative & Supportive Care , Volume 20 , Issue 3 , June 2022 , pp. 328 - 333
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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References

American College of Surgeons Commission on Cancer (2016) Ensuring Patient-Centered Care. Cancer Program Standards.Google Scholar
Balentine, CJ, Hermosillo-Rodriguez, J, Robinson, CN, et al. (2011) Depression is associated with prolonged and complicated recovery following colorectal surgery. Journal of Gastrointestinal Surgery 15(10), 1712–1717.10.1007/s11605-011-1640-5CrossRefGoogle ScholarPubMed
Barrera, I and Spiegel, D (2014) Review of psychotherapeutic interventions on depression in cancer patients and their impact on disease progression. International Review of Psychiatry 26(1), 31–43.CrossRefGoogle ScholarPubMed
Bergerot, CD, Bergerot, PG, Philip, EJ, et al. (2018) Assessment of distress and quality of life in rare cancers. Psycho-Oncology 27(12), 2740–2746.10.1002/pon.4873CrossRefGoogle ScholarPubMed
Brown, LF and Kroenke, K (2009) Cancer-related fatigue and its associations with depression and anxiety: A systematic review. Psychosomatics 50(5), 440–447.10.1016/S0033-3182(09)70835-7CrossRefGoogle ScholarPubMed
Carlson, LE, Angen, M, Cullum, J, et al. (2004) High levels of untreated distress and fatigue in cancer patients. British Journal of Cancer 90(12), 2297–2304.10.1038/sj.bjc.6601887CrossRefGoogle ScholarPubMed
Coiffier, B, Lepage, E, Briere, J, et al. (2002) CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. New England Journal of Medicine 346(4), 235–242.10.1056/NEJMoa011795CrossRefGoogle ScholarPubMed
Coiffier, B, Thieblemont, C, Van Den Neste, E, et al. (2010) Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: A study by the groupe d'Etudes des lymphomes de l'Adulte. Blood 116(12), 2040–2045.10.1182/blood-2010-03-276246CrossRefGoogle ScholarPubMed
Crespi, CM, Smith, SK, Petersen, L, et al. (2010) Measuring the impact of cancer: A comparison of non-Hodgkin lymphoma and breast cancer survivors. Journal of Cancer Survivorship 4(1), 45–58.10.1007/s11764-009-0106-1CrossRefGoogle ScholarPubMed
Crump, M, Neelapu, SS, Farooq, U, et al. (2017) Outcomes in refractory diffuse large B-cell lymphoma: Results from the international SCHOLAR-1 study. Blood 130(16), 1800–1808.10.1182/blood-2017-03-769620CrossRefGoogle ScholarPubMed
Delgado-Guay, M, Parsons, HA, Li, Z, et al. (2009) Symptom distress in advanced cancer patients with anxiety and depression in the palliative care setting. Supportive Care in Cancer 17(5), 573–579.10.1007/s00520-008-0529-7CrossRefGoogle ScholarPubMed
Druss, BG and Newcomer, JW (2007) Challenges and solutions to integrating mental and physical health care. Journal of Clinical Psychiatry 68(4), e09.Google ScholarPubMed
Epping-Jordan, JE, Compas, BE, Osowiecki, DM, et al. (1999) Psychological adjustment in breast cancer: Processes of emotional distress. Health Psychology 18(4), 315.10.1037/0278-6133.18.4.315CrossRefGoogle ScholarPubMed
Fujii, M, Ohno, Y, Tokumaru, Y, et al. (2001) Manifest anxiety scale for evaluation of effects of granisetron in chemotherapy with CDDP and 5FU for head and neck cancer. Supportive Care in Cancer 9(5), 366–371.10.1007/s005200000221CrossRefGoogle ScholarPubMed
Graves, KD, Arnold, SM, Love, CL, et al. (2007) Distress screening in a multidisciplinary lung cancer clinic: Prevalence and predictors of clinically significant distress. Lung Cancer 55(2), 215–224.10.1016/j.lungcan.2006.10.001CrossRefGoogle Scholar
Greer, JA, Pirl, WF, Park, ER, et al. (2008) Behavioral and psychological predictors of chemotherapy adherence in patients with advanced non-small cell lung cancer. Journal of Psychosomatic Research 65(6), 549–552.CrossRefGoogle ScholarPubMed
Head, BA, Studts, JL, Bumpous, JM, et al. (2009) Development of a telehealth intervention for head and neck cancer patients. Telemedicine and e-Health 15(1), 44–52.CrossRefGoogle ScholarPubMed
Hinz, A, Krauss, O, Hauss, JP, et al. (2010) Anxiety and depression in cancer patients compared with the general population. European Journal of Cancer Care 19(4), 522–529.10.1111/j.1365-2354.2009.01088.xCrossRefGoogle ScholarPubMed
Hopwood, P, Howell, A and Maguire, P (1991) Screening for psychiatric morbidity in patients with advanced breast cancer: Validation of two self-report questionnaires. British Journal of Cancer 64(2), 353–356.CrossRefGoogle ScholarPubMed
Horney, DJ, Smith, HE, McGurk, M, et al. (2011) Associations between quality of life, coping styles, optimism, and anxiety and depression in pretreatment patients with head and neck cancer. Head and Neck 33(1), 65–71.CrossRefGoogle ScholarPubMed
Howlader, N, Noone, AM, Krapcho, M, et al. (2016) SEER Cancer Statistics Review, 1975–2013, National Cancer Institute, Bethesda, MD, based on November 2015 SEER data submission. Posted to the SEER web site.Google Scholar
Institute of Medicine (US) Committee on Psychosocial Services to Cancer Patients/Families in a Community Setting (2008) Cancer care for the whole patient: Meeting psychosocial health needs. Washington, DC. Retrieved from: http://www.iom.edu/Reports.aspx.Google Scholar
Jayadevappa, R, Malkowicz, SB, Chhatre, S, et al. (2012) The burden of depression in prostate cancer. Psycho-Oncology 21(12), 1338–1345.CrossRefGoogle ScholarPubMed
Jensen, RE, Arora, NK, Bellizzi, KM, et al. (2013) Health-related quality of life among survivors of aggressive non-Hodgkin lymphoma. Cancer 119(3), 672–680.10.1002/cncr.27781CrossRefGoogle ScholarPubMed
Joy, KA, Ndindjock, R, Coyle, KB, et al. (2013) The burden of illness and prevalence In diffuse large B-cell (DLBCL) and follicular (FL) lymphomas. Blood 122(21), 5619.Google Scholar
Keat, N, Law, K, Seymour, M, et al. (2013) International rare cancers initiative. The Lancet Oncology 14(2), 109.10.1016/S1470-2045(12)70570-3CrossRefGoogle ScholarPubMed
Kelly, JL, Pandya, C, Friedberg, JW, et al. (2012) Health-related quality of life in older patients following diffuse large B-cell lymphoma (DLBCL) diagnosis. Blood 120(21), 4287.CrossRefGoogle Scholar
Krigel, S, Nelson, E-L, Spaulding, A, et al. (2014) Psycho-oncology via telemedicine: A model to provide services to a rural population. American Society of Clinical Oncology 32(31), doi:10.1200/jco.2014.32.31_suppl.236.CrossRefGoogle Scholar
Kuenstner, S, Langelotz, C, Budach, V, et al. (2002) The comparability of quality of life scores. A multitrait multimethod analysis of the EORTC QLQ-C30, SF-36 and FLIC questionnaires. European Journal of Cancer 38(3), 339–348.10.1016/S0959-8049(01)00369-0CrossRefGoogle ScholarPubMed
Loquai, C, Scheurich, V, Syring, N, et al. (2013) Screening for distress in routine oncological care—A survey in 520 melanoma patients. PLoS ONE 8(7), e66800.CrossRefGoogle ScholarPubMed
Mack, JW, Block, SD, Nilsson, M, et al. (2009) Measuring therapeutic alliance between oncologists and patients with advanced cancer: The human connection scale. Cancer 115(14), 3302–3311. doi:10.1002/cncr.24360CrossRefGoogle ScholarPubMed
Mausbach, BT and Irwin, SA (2016) Depression and healthcare service utilization in patients with cancer. Psycho-Oncology. doi:10.1002/pon.4133Google ScholarPubMed
Mitchell, AJ (2010) Short screening tools for cancer-related distress: A review and diagnostic validity meta-analysis. Journal of the National Comprehensive Cancer Network 8(4), 487–494.CrossRefGoogle ScholarPubMed
Moorey, S, Greer, S, Watson, M, et al. (1991) The factor structure and factor stability of the hospital anxiety and depression scale in patients with cancer. The British Journal of Psychiatry 158(2), 255–259. doi:10.1192/bjp.158.2.255CrossRefGoogle ScholarPubMed
Mosher, CE and DuHamel, KN (2012) An examination of distress, sleep, and fatigue in metastatic breast cancer patients. Psycho-Oncology 21(1), 100–107. doi:10.1002/pon.1873CrossRefGoogle ScholarPubMed
Mosher, CE, Winger, JG, Hanna, N, et al. (2014) Barriers to mental health service use and preferences for addressing emotional concerns among lung cancer patients. Psycho-Oncology 23(7), 812–819. doi:10.1002/pon.3488CrossRefGoogle ScholarPubMed
Norton, TR, Manne, SL, Rubin, S, et al. (2004) Prevalence and predictors of psychological distress among women with ovarian cancer. Journal of Clinical Oncology 22(5), 919–926.CrossRefGoogle ScholarPubMed
Oberoi, DV, White, VM, Seymour, JF, et al. (2017) Distress and unmet needs during treatment and quality of life in early cancer survivorship: A longitudinal study of haematological cancer patients. European Journal of Haematology 99(5), 423–430.10.1111/ejh.12941CrossRefGoogle ScholarPubMed
Parikh, SA, Rabe, KG, Call, TG, et al. (2013) Diffuse large B-cell lymphoma (richter syndrome) in patients with chronic lymphocytic leukaemia (CLL): A cohort study of newly diagnosed patients. British Journal of Haematology 162(6), 774–782. doi:10.1111/bjh.12458CrossRefGoogle ScholarPubMed
Pedersen, AE, Sawatzky, JA and Hack, TF (2010) The sequelae of anxiety in breast cancer: A human response to illness model. Oncology Nursing Forum 37(4), 469–475. doi:10.1188/10.onf.469-475CrossRefGoogle ScholarPubMed
Prieto, JM, Blanch, J, Atala, J, et al. (2002) Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stem-cell transplantation. Journal of Clinical Oncology 20(7), 1907–1917.CrossRefGoogle ScholarPubMed
Reddy, SK, Parsons, HA, Elsayem, A, et al. (2009) Characteristics and correlates of dyspnea in patients with advanced cancer. Journal of Palliative Medicine 12(1), 29–36. doi:10.1089/jpm.2008.0158CrossRefGoogle ScholarPubMed
Sant, M, Minicozzi, P, Mounier, M, et al. (2014) Survival for haematological malignancies in Europe between 1997 and 2008 by region and age: Results of EUROCARE-5, a population-based study. The Lancet Oncology 15(9), 931–942. doi:10.1016/s1470-2045(14)70282-7CrossRefGoogle ScholarPubMed
Shepherd, L, Goldstein, D, Olver, I, et al. (2008) Enhancing psychosocial care for people with cancer in rural communities: What can remote counselling offer? Australian Health Review 32(3), 423–438.CrossRefGoogle ScholarPubMed
Smith, EM, Gomm, SA and Dickens, CM (2003) Assessing the independent contribution to quality of life from anxiety and depression in patients with advanced cancer. Palliative Medicine 17(6), 509–513.CrossRefGoogle ScholarPubMed
Smith, SK, Zimmerman, S, Williams, CS, et al. (2009) Health status and quality of life among non-Hodgkin lymphoma survivors. Cancer 115(14), 3312–3323. doi:10.1002/cncr.24391CrossRefGoogle ScholarPubMed
Strong, V, Waters, R, Hibberd, C, et al. (2007) Emotional distress in cancer patients: The Edinburgh cancer centre symptom study. British Journal of Cancer 96(6), 868–874. doi:10.1038/sj.bjc.6603626CrossRefGoogle ScholarPubMed
Surveillance Research Program, National Cancer Institute (2000–2011) Incidence rates of NHL subtypes in the USA. Surveillance, Epidemiology, and End-Results Program.Google Scholar
Trevino, KM, Healy, C, Martin, P, et al. (2018) Improving implementation of psychological interventions to older adult patients with cancer: Convening older adults, caregivers, providers, researchers. Journal of Geriatric Oncology 9(5), 423–429. doi:10.1016/j.jgo.2018.04.007CrossRefGoogle ScholarPubMed
Trevino, KM, Canin, B, Healy, C, et al. (2020) Bridging the Gap between aging research and practice: A new strategy for enhancing the consensus workshop model. Journal of Applied Gerontology 39(6), 677–680. doi:10.1177/0733464818791433CrossRefGoogle ScholarPubMed
Van Den Neste, E, Schmitz, N, Mounier, N, et al. (2015) Outcome of patients with relapsed diffuse large B-cell lymphoma who fail second-line salvage regimens in the international CORAL study. Bone Marrow Transplantation 51(1), 51–57. doi:10.1038/bmt.2015.213CrossRefGoogle ScholarPubMed
Van Der Poel, M, Oerlemans, S, Schouten, H, et al. (2014) Quality of life more impaired in younger than in older diffuse large B cell lymphoma survivors compared to a normative population: A study from the population-based PROFILES registry. Annals of Hematology 93(5), 811–819.CrossRefGoogle ScholarPubMed
Vodermaier, A, Linden, W and Siu, C (2009) Screening for emotional distress in cancer patients: A systematic review of assessment instruments. Journal of the National Cancer Institute 101(21), 1464–1488. doi:10.1093/jnci/djp336CrossRefGoogle ScholarPubMed
Wagner, LI, Spiegel, D and Pearman, T (2013) Using the science of psychosocial care to implement the new American college of surgeons commission on cancer distress screening standard. Journal of the National Comprehensive Cancer Network 11(2), 214–221.CrossRefGoogle ScholarPubMed
Walker, J, Postma, K, McHugh, GS, et al. (2007) Performance of the hospital anxiety and depression scale as a screening tool for major depressive disorder in cancer patients. Journal of Psychosomatic Research 63(1), 83–91. doi:10.1016/j.jpsychores.2007.01.009CrossRefGoogle ScholarPubMed
Ware, JE (2002) User's Manual for the SF-12v2 Health Survey (with a Supplement Documenting SF-12 Health Survey). QualityMetric Incorporated.Google Scholar
Ware, JE Jr, Kosinski, M and Keller, SD (1996) A 12-item short-form health survey: Construction of scales and preliminary tests of reliability and validity. Medical Care 34(3), 220–233.CrossRefGoogle ScholarPubMed
Weinberger, MI, Bruce, ML, Roth, AJ, et al. (2011) Depression and barriers to mental health care in older cancer patients. International Journal of Geriatric Psychiatry 26(1), 21–26.CrossRefGoogle ScholarPubMed
Zabora, J, BrintzenhofeSzoc, K, Curbow, B, et al. (2001) The prevalence of psychological distress by cancer site. Psycho-Oncology 10(1), 19–28.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Zenger, M, Lehmann-Laue, A, Stolzenburg, J-U, et al. (2010) The relationship of quality of life and distress in prostate cancer patients compared to the general population. GMS Psycho-Social Medicine 7, doi:10.3205/psm000064.Google ScholarPubMed
Zigmond, AS and Snaith, RP (1983) The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica 67(6), 361–370.CrossRefGoogle ScholarPubMed