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Health-related quality of life of patients on antiretroviral treatment in Botswana: A cross-sectional study

Published online by Cambridge University Press:  12 August 2016

Nnamdi O. Ndubuka ,
Hyun J. Lim ,
Valerie J. Ehlers  and
Dirk M. van der Wal
Nnamdi O. Ndubuka
Affiliation:
University of South Africa, Pretoria, Republic of South Africa Northern Inter-Tribal Health Authority, Prince Albert, Saskatchewan, Canada
Hyun J. Lim
Affiliation:
University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Valerie J. Ehlers*
Affiliation:
University of South Africa, Pretoria, Republic of South Africa
Dirk M. van der Wal
Affiliation:
University of South Africa, Pretoria, Republic of South Africa
*
Address correspondence and reprint requests to: Valerie J. Ehlers, P.O. Box 65075, Erasmusrand, Pretoria 0165, Republic of South Africa. E-mail: [email protected].
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Abstract

Objective:

Antiretroviral therapy (ART) affords longevity to patients infected with the human immune deficiency virus (HIV). Since little is known about the health-related quality of life (HRQoL) of persons who have been on ART for at least five years, the present study investigated the HRQoL of these patients in Botswana.

Method:

Medical records, structured interviews, and the World Health Organization Quality of Life–BREF (WHOQoL–HIV–BREF) instrument were employed to obtain information from 456 respondents.

Results:

Univariate and multivariate regression analyses showed that respondents' highest scores were in the “physical” domain (mean = 15.8, SD = 3.5), while the lowest scores were in the “environment” domain (mean = 12.9, SD = 2.5). Thus, the physical domain had the greatest impact on patients' overall HRQoL. Self-education about HIV-related issues was significantly correlated with all domains of HRQoL scores: physical (ρ = –2.32, CI95% = –3.02, –1.61); psychological (ρ = –2.26, CI95% = –2.87, –1.65); independence (ρ = –1.81, CI95% = –2.54, –1.06); social relationships (ρ = –1.40, CI95% = –2.13, –0.67); environment (ρ = –1.58, CI95% = –2.13, –1.04); and spirituality (ρ = –1.70, CI95% = –82.27, –1.13).

Significance of results:

HRQoL assessments can identify and address patients' needs, and it is important that guidelines be developed that will yield improved care to ART patients in Botswana.

Keywords

Antiretroviral therapyHealth-related quality of lifeHRQoLHIV/AIDSWHOQoL–HIV–BrefBotswana
Type
Original Articles
Information
Palliative & Supportive Care , Volume 15 , Issue 2 , April 2017 , pp. 214 - 222
Copyright
Copyright © Cambridge University Press 2016 

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References

REFERENCES

Abasiubong, F., Ekott, J.U., Bassey, E.A., et al. (2010). Quality of life in people living with HIV/AIDS in Niger-Delta region, Nigeria. Journal of Mental Health, 19(2), 211–218.CrossRefGoogle ScholarPubMed
Antiretroviral Therapy Cohort (2008). Life expectancy of individuals on combined antiretroviral therapy in high-income countries: A collaboration of 14 cohort studies. Lancet, 372(9635), 293–299.Google Scholar
Boateng, D., Kwapong, G.D. & Agyei-Baffour, P. (2013). Knowledge, perception about antiretroviral therapy (ART) and prevention of mother-to-child transmission (PMTCT), and adherence to ART among HIV-positive women in the Ashanti Region, Ghana: A cross-sectional study. BMC Women's Health, 13, 2. Available from http://www.biomedcentral.com/content/pdf/1472-6874-13-2.pdf.CrossRefGoogle ScholarPubMed
Burgoyne, R.W. & Tan, D.H. (2008). Prolongation and quality of life for HIV-infected adults treated with highly active antiretroviral therapy (HAART): A balancing act. Journal of Antimicrobial Chemotherapy, 61(3), 469–473.Google Scholar
Campbell, C., Skovdal, M., Madanhire, C., et al. (2011). “We, the AIDS people …”: How antiretroviral therapy enables Zimbabweans living with AIDS to cope with stigma. American Journal of Public Health, 101(6), 1004–1010. Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093282/.Google Scholar
Chaudoir, S.R., Norton, W.E., Earnsaw, V.A., et al. (2012). Coping with HIV stigma: Do proactive coping and spiritual peace buffer the effect of stigma on depression? AIDS and Behavior, 16(8), 2382–2391.Google Scholar
Cloete, A., Strebel, A., Simnayi, L., et al. (2010). Challenges faced by people living with HIV/AIDS in Cape Town, South Africa: Issues for group risk reduction interventions. AIDS Research and Treatment, 2010, Article ID 420270. Available from http://www.hindawi.com/journals/art/2010/420270/.Google Scholar
Degroote, S., Vogelaers, D. & Vandijck, D.M. (2014). What determines health-related quality of life among people living with HIV: An updated review of the literature. Archives of Public Health, 72(1), 40. Available from http://www.archpublichealth.com/content/pdf/2049-3258-72-40.pdf.CrossRefGoogle ScholarPubMed
Farahani, M., Vable, A., Lebelonyane, R., et al. (2014). Outcomes of the Botswana national HIV/AIDS treatment programme from 2002 to 2010: A longitudinal analysis. The Lancet. Global Health, 2(1), e44–e50. Available from http://www.thelancet.com/pdfs/journals/langlo/PIIS2214109X13701499.pdf.Google Scholar
Fatiregun, A.A., Mofolorunsho, K.C. & Osagbemi, K.G. (2009). Quality of life of people living with HIV/AIDS in Kogi Sate, Nigeria. Benin Journal of Postgraduate Medicine, 11(1), 21–27. Available from http://www.ajol.info/index.php/bjpm/article/view/48823/35172.Google Scholar
Figuero, L.S., Luque, P.B., Martín, T.P., et al. (2011). Assessment of factors influencing health-related quality of life in HIV-infected patients. HIV Medicine, 22(1), 22–30. Available from http://onlinelibrary.wiley.com/doi/10.1111/j.1468-1293.2010.00844.x/pdf.Google Scholar
Folasire, O.F., Irabor, A.E. & Folasire, A.M. (2012). Quality of life of people living with HIV and AIDS attending the antiretroviral clinic, University College Hospital, Nigeria. African Journal of Primary Health Care & Family Medicine, 4(1), 1–8. Available from http://www.phcfm.org/index.php/phcfm/article/viewFile/294/335.Google Scholar
Government of Botswana (2014). Population and housing census 2011: Analytical report. Available from http://www.cso.gov.bw/images/analytical_report.pdf.Google Scholar
Hodge, D.R. & Roby, J.L. (2010). Sub-Saharan African women living with HIV/AIDS: An exploration of general and spiritual coping strategies. Social Work, 55(1), 27–37.Google Scholar
McInerney, P.A., Ncama, B.P., Wantland, D., et al. (2008). Quality of life and physical functioning in HIV-infected individuals receiving antiretroviral therapy in KwaZulu–Natal, South Africa. Nursing & Health Sciences, 10(4), 266–272.Google Scholar
Ministry of Health (2011). HAART patient update summary: April 2011. Gaborone, Botswana: Ministry of Health.Google Scholar
Morandi dos Santos, E.C., Franca, I. Jr. & Lopez, F. (2007). Quality of life of people living with HIV/AIDS in São Paulo, Brazil. Revista de Saúde Pública, 41(Suppl. 2), 64–71. Available from http://www.scielosp.org/pdf/rsp/v41s2/en_5947.pdf.Google Scholar
Munsawaengsub, C., Khair, B. & Nanthamongkolchai, S. (2012). People living with HIV/AIDS in the city of Bangkok: Quality of life and related factors. Journal of the Medical Association of Thailand, 95(Suppl. 6), S127–S134. Available from http://ns2.ph.mahidol.ac.th/phklb/knowledgefiles/People_Living_with_HIV.pdf.Google Scholar
National AIDS Coordinating Agency (2014). Progress report of the national response to the 2011 declaration of commitment on HIV and AIDS, Botswana country report 2013. Available from http://www.unaids.org/sites/default/files/country/documents//file,94425,es..pdf.Google Scholar
Ndubuka, N.O. & Ehlers, V.J. (2011). Adult patients' adherence to antiretroviral treatment: A survey correlating pharmacy refill records and pill counts with immunological and virological indices. International Journal of Nursing Studies, 48(11), 1323–1329.Google Scholar
Ogbuji, Q.C. & Oke, A.E. (2010). Quality of life among persons living with HIV infection in Ibadan, Nigeria. African Journal of Medicine and Medical Sciences, 39(2), 127–135.Google ScholarPubMed
Reda, A.A. & Biadgilign, S. (2012). Determinants of adherence to antiretroviral therapy among HIV-infected patients in Africa. AIDS Research and Treatment, 2012, Article ID 574656. Available from http://www.hindawi.com/journals/art/2012/574656/.Google Scholar
Republic of Botswana (2013). Preliminary result: Botswana AIDS impact survey, IV. Gaborone: Central Statistics Office. Available from http://www.cso.gov.bw/images/aids_summary.pdf.Google Scholar
Sarna, A., Pujari, S., Sengar, A.K., et al. (2008). Adherence to antiretroviral therapy and its determinants amongst HIV patients in India. Indian Journal of Medical Research, 127, 28–36. Available from http://www.icmr.nic.in/ijmr/2008/january/0104.pdf.Google Scholar
Sendagala, S. (2010). Factors affecting the adherence to antiretroviral therapy by HIV-positive patients treated in a community-based HIV/AIDS care programme in rural Uganda: A case of Tororo district. Master of Public Health dissertation. Pretoria: University of South Africa.Google Scholar
Sekabira, R., Nankya-Mutyoba, J., Makumbi, F., et al. (2012). Determinants of health-related quality of life among adults in routine HIV care, Kampala, Uganda. Open Access Scientific Report, 1(11), 1–6. Available from http://www.omicsonline.org/scientific-reports/2155-6113-SR-515.pdf.Google Scholar
Skevington, S.M, Norweg, S., Standage, M., et al. (2010). Predicting quality of life for people living with HIV and AIDS: International evidence from seven cultures. AIDS Care, 22(5), 614–622.Google Scholar
Stutterheim, S., Bos, A.E.R, Pryor, J.B., et al. (2011). Psychological and social disclosure: The significance of stigma visibility. AIDS Education and Prevention, 23(4), 382–392.Google Scholar
Tran, B.X. (2012). Quality of life outcomes of antiretroviral treatment for HIV/AIDS patients in Vietnam. PLoS One, 7(7), e4162. Available from http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0041062&representation=PDF.CrossRefGoogle ScholarPubMed
Tsevat, J. (2006). Spirituality/religion and quality of life in patients with HIV/AIDS. Journal of General Internal Medicine, 21(Suppl. 5), S1–S2. Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924786/pdf/jgi0021-00S1.pdf.CrossRefGoogle Scholar
United Nations Joint Programme on HIV/AIDS/World Health Organization (2016). World AIDS Day 2015 Fact Sheet. Geneva. Available from http://www.unaids.org/sites/default/files/media_asset/20150901_FactSheet_2015_en.pdf,Google Scholar
Vyavaharkar, M., Moneyham, L., Tavakoli, A., et al. (2007). Social support, coping, and medication adherence among HIV-positive women with depression living in rural areas of the southeastern United States. AIDS Patient Care and STDs, 21(9), 667–680.Google Scholar
World Health Organization Quality of Life Group (1998). Introducing the WHOQoL instruments. Department of Mental Health and Substance Dependency, Geneva: World Health Organization. Available from http://depts.washington.edu/yqol/docs/WHOQoL_Info.pdf.Google Scholar
World Health Organization Quality of Life–HIV Group (2002). WHOQoL–HIV instrument: Scoring and coding for WHOQoL–HIV instruments: Users manual. Geneva: World Health Organization. Available from http://www.who.int/mental_health/media/en/613.pdf.Google Scholar
World Health Organization Quality of Life–HIV Group (2004). WHOQoL–HIV Quality of Life assessment among people living with HIV and AIDS: Results from the field test. AIDS Care, 16(7), 882–889.Google Scholar