This article demonstrates how the Enlightenment model of sentiment and sympathy is performed in embodied gestures of affective empathy-building, cross-cultural fraternity, and concern for human rights in three Romantic Regency tragedies: Pizarro (1799) by the Romantic dramatist August von Kotzebue, adapted from the German by the Irish dramatist Richard Brinsley Sheridan; Remorse (1813) by the English poet Samuel Taylor Coleridge; and The Apostate (1817) by the Irish dramatist Richard Lalor Sheil. In these plays, protagonists are moved towards sympathy and solidarity with others across cultural divisions and conflict. The discussion also examines how human rights issues are addressed in two plays by Scottish dramatists: Archibald MacLaren’s The Negro Slaves (1799) and Joanna Baillie’s Rayner (1804). Here the protagonists express remorse for engaging in conflict, colonialism, slavery, violence, and human rights abuses against others. All these texts share a common internationalist desire to unite humanity against oppression, injustice, and inequality, advocating human rights, equality, religious tolerance, and cosmopolitan citizenship.