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Synaptic plasticity and Ca2+ signalling in astrocytes

Published online by Cambridge University Press:  13 October 2010

Christian Henneberger  and
Dmitri A. Rusakov
Christian Henneberger*
Affiliation:
UCL Institute of Neurology, University College London, Queen Square, London, UK
Dmitri A. Rusakov*
Affiliation:
UCL Institute of Neurology, University College London, Queen Square, London, UK
*
Correspondence should be addressed to: Dmitri Rusakov and Christian Henneberger, UCL Institute of Neurology, University College London, Queen Square, London WC1N 2BG, UK emails: [email protected] and [email protected]
Correspondence should be addressed to: Dmitri Rusakov and Christian Henneberger, UCL Institute of Neurology, University College London, Queen Square, London WC1N 2BG, UK emails: [email protected] and [email protected]
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Abstract

There is a growing body of evidence suggesting a functional relationship between Ca2+ signals generated in astroglia and the functioning of nearby excitatory synapses. Interference with endogenous Ca2+ homeostasis inside individual astrocytes has been shown to affect synaptic transmission and its use-dependent changes. However, establishing the causal link between source-specific, physiologically relevant intracellular Ca2+ signals, the astrocytic release machinery and the consequent effects on synaptic transmission has proved difficult. Improved methods of Ca2+ monitoring in situ will be essential for resolving the ambiguity in understanding the underlying Ca2+ signalling cascades.

Keywords

Astrocyteplasticitygliasynapse
Type
Research Article
Information
Neuron Glia Biology , Volume 6 , Issue 3 , August 2010 , pp. 141 - 146
Copyright
Copyright © Cambridge University Press 2010

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