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The evolution of Olig genes and their roles in myelination

Published online by Cambridge University Press:  08 September 2009

Huiliang Li  and
William D. Richardson
Huiliang Li
Affiliation:
Wolfson Institute for Biomedical Research and Research, Department of Cell and Developmental Biology, University College London, London, UK
William D. Richardson*
Affiliation:
Wolfson Institute for Biomedical Research and Research, Department of Cell and Developmental Biology, University College London, London, UK
*
Correspondence should be addressed to: William D. Richardson, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK phone: +44 (0)20 7679 6729 fax: +44 (0)20 7209 0470 email: [email protected]
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Abstract

One of the special attributes of vertebrates is their myelinated nervous system. By increasing the conduction velocity of axons, myelin allows for increased body size, rapid movement and a large and complex brain. In the central nervous system (CNS), oligodendrocytes (OLs) are the myelin-forming cells. The transcription factors OLIG1 and OLIG2, master regulators of OL development, presumably also played a seminal role during the evolution of the genetic programme leading to myelination in the CNS. From the available ontogenetic and phylogenetic data we attempt to reconstruct the evolutionary events that led to the emergence of the Olig gene family and speculate about the links between Olig genes, their specific cis-regulatory elements and myelin evolution. In addition, we report a putative myelin basic protein (MBP) ancestor in the lancelet Branchiostoma floridae, which lacks compact myelin. The lancelet ‘Mbp’ gene lacks the OLIG1/2- and SOX10-binding sites that characterize vertebrate Mbp homologs, raising the possibility that insertion of cis-regulatory elements might have been involved in evolution of the myelinating programme.

Keywords

MyelinOlig genesevolution and development (evo-devo)behaviourmyelin basic protein
Type
Research Article
Information
Neuron Glia Biology , Volume 4 , Issue 2 , May 2008 , pp. 129 - 135
Copyright
Copyright © Cambridge University Press 2009

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